Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q74R94

- GPPA_YERPE

UniProt

Q74R94 - GPPA_YERPE

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. exopolyphosphatase activity Source: InterPro
    2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
    3. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
    3. polyphosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:YPO3870, y0358, YP_3175
    OrganismiYersinia pestis
    Taxonomic identifieri632 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194297Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi229193.YP_3175.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74R94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiSYVHWAL.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR022371. Exopolyphosphatase.
    IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q74R94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLSSTSLYA AIDLGSNSFH MLVVREVAGS IQTLARIKRK VRLAAGLDNQ    50
    NHLSQEAMER GWQCLKLFSE RLQDIPLDQI RVVATATLRL ASNADEFLRT 100
    ATEILGCPIQ VISGEEEARL IYHGVAHTTG GPEQRLVVDI GGGSTELVTG 150
    NGAQANILVS LSMGCVTWLE RYFGDRHLAK ENFERAELAA HEMIKPVAQR 200
    FREHGWQVCV GASGTVQALQ EIMVAQGMDE LITLAKLQQL KQRAIQCGKL 250
    EELEIPGLTL ERALVFPSGL SILIAIFQEL SIESMTLAGG ALREGLVYGM 300
    LHLPVEQDIR RRTLRNLQRR YLLDTEQAKR VSCLADNFFL QVEKEWHLDG 350
    RCREFLQNAC LIHEIGLSVD FKHAPQHAAY LIRNLDLPGF TPAQKLLLSA 400
    LLQNQSDTID LSLLNQQNAL PADMAQHLCR LLRLAIIFSS RRRDDTLPAV 450
    RLRADNNALY VLVPQGWLEQ HPYRAEALEQ ESHWQSYVQW PLLLEELS 498
    Length:498
    Mass (Da):55,926
    Last modified:July 5, 2004 - v1
    Checksum:i583A72F958AFFEB5
    GO

    Sequence cautioni

    The sequence AE009952 differs from that shown. Reason: Frameshift at position 143.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. No translation available.
    AE009952 Genomic DNA. No translation available.
    AE017042 Genomic DNA. Translation: AAS63343.1.
    RefSeqiNP_994466.1. NC_005810.1.

    Genome annotation databases

    EnsemblBacteriaiAAS63343; AAS63343; YP_3175.
    GeneIDi2765920.
    KEGGiypm:YP_3175.
    PATRICi18625474. VBIYerPes99487_3635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590842 Genomic DNA. No translation available.
    AE009952 Genomic DNA. No translation available.
    AE017042 Genomic DNA. Translation: AAS63343.1 .
    RefSeqi NP_994466.1. NC_005810.1.

    3D structure databases

    ProteinModelPortali Q74R94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 229193.YP_3175.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS63343 ; AAS63343 ; YP_3175 .
    GeneIDi 2765920.
    KEGGi ypm:YP_3175.
    PATRICi 18625474. VBIYerPes99487_3635.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi SYVHWAL.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR022371. Exopolyphosphatase.
    IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CO-92 / Biovar Orientalis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KIM10+ / Biovar Mediaevalis.
    3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
      Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
      , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
      DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 91001 / Biovar Mediaevalis.

    Entry informationi

    Entry nameiGPPA_YERPE
    AccessioniPrimary (citable) accession number: Q74R94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    In strain CO-92 it seems to be a pseudogene. It is interrupted by frameshifts in positions 90 and 143. The sequence has been verified by the authors and is believed to be correct.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3