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Q74R94

- GPPA_YERPE

UniProt

Q74R94 - GPPA_YERPE

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Yersinia pestis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. exopolyphosphatase activity Source: InterPro
  2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
  3. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:YPO3870, y0358, YP_3175
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000815: Chromosome, UP000001019: Chromosome, UP000002490: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194297Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi229193.YP_3175.

Structurei

3D structure databases

ProteinModelPortaliQ74R94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74R94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLSSTSLYA AIDLGSNSFH MLVVREVAGS IQTLARIKRK VRLAAGLDNQ
60 70 80 90 100
NHLSQEAMER GWQCLKLFSE RLQDIPLDQI RVVATATLRL ASNADEFLRT
110 120 130 140 150
ATEILGCPIQ VISGEEEARL IYHGVAHTTG GPEQRLVVDI GGGSTELVTG
160 170 180 190 200
NGAQANILVS LSMGCVTWLE RYFGDRHLAK ENFERAELAA HEMIKPVAQR
210 220 230 240 250
FREHGWQVCV GASGTVQALQ EIMVAQGMDE LITLAKLQQL KQRAIQCGKL
260 270 280 290 300
EELEIPGLTL ERALVFPSGL SILIAIFQEL SIESMTLAGG ALREGLVYGM
310 320 330 340 350
LHLPVEQDIR RRTLRNLQRR YLLDTEQAKR VSCLADNFFL QVEKEWHLDG
360 370 380 390 400
RCREFLQNAC LIHEIGLSVD FKHAPQHAAY LIRNLDLPGF TPAQKLLLSA
410 420 430 440 450
LLQNQSDTID LSLLNQQNAL PADMAQHLCR LLRLAIIFSS RRRDDTLPAV
460 470 480 490
RLRADNNALY VLVPQGWLEQ HPYRAEALEQ ESHWQSYVQW PLLLEELS
Length:498
Mass (Da):55,926
Last modified:July 5, 2004 - v1
Checksum:i583A72F958AFFEB5
GO

Sequence cautioni

The sequence AE009952 differs from that shown. Reason: Frameshift at position 143.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. No translation available.
AE009952 Genomic DNA. No translation available.
AE017042 Genomic DNA. Translation: AAS63343.1.
RefSeqiNP_994466.1. NC_005810.1.

Genome annotation databases

EnsemblBacteriaiAAS63343; AAS63343; YP_3175.
GeneIDi2765920.
KEGGiypm:YP_3175.
PATRICi18625474. VBIYerPes99487_3635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590842 Genomic DNA. No translation available.
AE009952 Genomic DNA. No translation available.
AE017042 Genomic DNA. Translation: AAS63343.1 .
RefSeqi NP_994466.1. NC_005810.1.

3D structure databases

ProteinModelPortali Q74R94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 229193.YP_3175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS63343 ; AAS63343 ; YP_3175 .
GeneIDi 2765920.
KEGGi ypm:YP_3175.
PATRICi 18625474. VBIYerPes99487_3635.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92 / Biovar Orientalis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KIM10+ / Biovar Mediaevalis.
  3. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001 / Biovar Mediaevalis.

Entry informationi

Entry nameiGPPA_YERPE
AccessioniPrimary (citable) accession number: Q74R94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

In strain CO-92 it seems to be a pseudogene. It is interrupted by frameshifts in positions 90 and 143. The sequence has been verified by the authors and is believed to be correct.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3