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Q74NT6

- ARSC1_BACC1

UniProt

Q74NT6 - ARSC1_BACC1

Protein

Protein ArsC 1

Gene

arsC1

Organism
Bacillus cereus (strain ATCC 10987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
    Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111Nucleophile; for reductase activity and phosphatase activityUniRule annotation
    Active sitei83 – 831Nucleophile; for reductase activityUniRule annotation
    Active sitei90 – 901Nucleophile; for reductase activityUniRule annotation

    GO - Molecular functioni

    1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
    2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. response to arsenic-containing substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Arsenical resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ArsC 1UniRule annotation
    Alternative name(s):
    Arsenate reductase 1UniRule annotation (EC:1.20.4.-UniRule annotation)
    Arsenical pump modifier 1UniRule annotation
    Low molecular weight protein-tyrosine-phosphatase 1UniRule annotation (EC:3.1.3.48UniRule annotation)
    Gene namesi
    Name:arsC1UniRule annotation
    Ordered Locus Names:BCE_A0158
    Encoded oniPlasmid pBc109870 Publication
    OrganismiBacillus cereus (strain ATCC 10987)
    Taxonomic identifieri222523 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002527: Plasmid pBc10987

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134Protein ArsC 1PRO_0000162512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi11 ↔ 83Redox-active; alternateUniRule annotation
    Disulfide bondi83 ↔ 90Redox-active; alternateUniRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi222523.BCE_A0158.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74NT6.
    SMRiQ74NT6. Positions 1-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273093.
    KOiK03741.
    OrthoDBiEOG6JDWJC.

    Family and domain databases

    HAMAPiMF_01624. Arsenate_reduct.
    InterProiIPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.
    TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q74NT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENKKTIYFL CTGNSCRSQM AEAWGKKYLG DKWNVLSAGI EAHGVNPNAI    50
    KAMKEVDIDI TDQTSDIIDR DILDKADLVV TLCGHANDVC PTTPPHVKRV 100
    HWGFDDPAGQ EWSVFQRVRD EIGARIKKYA ETGE 134
    Length:134
    Mass (Da):15,006
    Last modified:July 5, 2004 - v1
    Checksum:i63A6D7AE747B42D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017195 Genomic DNA. Translation: AAS45008.1.
    RefSeqiNP_982165.1. NC_005707.1.

    Genome annotation databases

    EnsemblBacteriaiAAS45008; AAS45008; BCE_A0158.
    GeneIDi2753115.
    KEGGibca:BCE_A0158.
    PATRICi18860163. VBIBacCer118379_5546.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017195 Genomic DNA. Translation: AAS45008.1 .
    RefSeqi NP_982165.1. NC_005707.1.

    3D structure databases

    ProteinModelPortali Q74NT6.
    SMRi Q74NT6. Positions 1-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 222523.BCE_A0158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS45008 ; AAS45008 ; BCE_A0158 .
    GeneIDi 2753115.
    KEGGi bca:BCE_A0158.
    PATRICi 18860163. VBIBacCer118379_5546.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273093.
    KOi K03741.
    OrthoDBi EOG6JDWJC.

    Family and domain databases

    HAMAPi MF_01624. Arsenate_reduct.
    InterProi IPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1."
      Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.
      Nucleic Acids Res. 32:977-988(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 10987.

    Entry informationi

    Entry nameiARSC1_BACC1
    AccessioniPrimary (citable) accession number: Q74NT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3