Q74NT6 (ARSC1_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ArsC 1

Alternative name(s):
Arsenate reductase 1
EC=1.20.4.-
Arsenical pump modifier 1
Low molecular weight protein-tyrosine-phosphatase 1
EC=3.1.3.48

Gene names

Name:	arsC1
Ordered Locus Names:	BCE_A0158

Encoded on

Plasmid pBc10987

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP MF_01624
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP MF_01624 Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP MF_01624
Subunit structure	Monomer By similarity. HAMAP MF_01624
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Domain	Redox-active center
Molecular function	Hydrolase Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (thioredoxin) activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	Protein ArsC 1 HAMAP MF_01624		PRO_0000162512
Sites
	Active site	11	1	Nucleophile; for reductase activity and phosphatase activity By similarity
	Active site	83	1	Nucleophile; for reductase activity By similarity
	Active site	90	1	Nucleophile; for reductase activity By similarity
Amino acid modifications
	Disulfide bond	11 ↔ 83		Redox-active; alternate By similarity
	Disulfide bond	83 ↔ 90		Redox-active; alternate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q74NT6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 63A6D7AE747B42D7	FASTA	134	15,006
	10 20 30 40 50 60 MENKKTIYFL CTGNSCRSQM AEAWGKKYLG DKWNVLSAGI EAHGVNPNAI KAMKEVDIDI 70 80 90 100 110 120 TDQTSDIIDR DILDKADLVV TLCGHANDVC PTTPPHVKRV HWGFDDPAGQ EWSVFQRVRD 130 EIGARIKKYA ETGE

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017195 Genomic DNA. Translation: AAS45008.1.
RefSeq	NP_982165.1. NC_005707.1.
3D structure databases
ProteinModelPortal	Q74NT6.
SMR	Q74NT6. Positions 1-134.
ModBase	Search...
Protein-protein interaction databases
STRING	Q74NT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000030481; EBBACP00000029687; EBBACG00000030472.
GeneID	2753115.
GenomeReviews	Gene locus BCE_A0158 in contig AE017195_GR.
KEGG	bca:BCE_A0158.
NMPDR	fig|222523.1.peg.5761.
PATRIC	18860163. VBIBacCer118379_5546.
TIGR	BCE_A0158.
Phylogenomic databases
eggNOG	COG0394.
GeneTree	EBGT00070000032125.
HOGENOM	HBG730979.
ProtClustDB	PRK13530.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_A0158-MONOMER.
Family and domain databases
HAMAP	MF_01624. Arsenate_reduct. [Tree]
InterPro	IPR014064. Arsenate_reductase_ArsC. IPR023485. Ptyr_pPase_SF. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
KO	K03741.
PANTHER	PTHR11717. Low_mwt_PTPase. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
TIGRFAMs	TIGR02691. ArsC_pI258_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARSC1_BACC1

Accession

Primary (citable) accession number: Q74NT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program