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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Nanoarchaeum equitans (strain Kin4-M)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciNEQU228908:GJB6-444-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:NEQ420
OrganismiNanoarchaeum equitans (strain Kin4-M)
Taxonomic identifieri228908 [NCBI]
Taxonomic lineageiArchaeaNanoarchaeotaNanoarchaeum
Proteomesi
  • UP000000578 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12431243DNA polymerase II large subunitPRO_0000294697Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi228908.NEQ420.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch. 1 hit.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74N29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYYDILAKE LEKLYEIAEK ARAQGYDPKD IVEIPLANNM GERVAHLISA
60 70 80 90 100
IHEQLDVKKT AELILELEKQ YGFLDWRVGL KLIDYALEGK LIPYDDILKR
110 120 130 140 150
IDLGVRLALG YITMGVVSAP LEGLVELRIK KRKDGKPYLA LYYAGPIRGA
160 170 180 190 200
GGTAAAVSVL FADYARKKAG LYEYDPTKEE IERYKIEIDS YHNKVARLQY
210 220 230 240 250
KPSDEEIEFL VKHIPVEING DPTSDKEVPS YKNLERVETN RIRGGMCLVI
260 270 280 290 300
AEGIAQKAKK IYGKITEWGK EFGLEHWEFL GEYLKLQKEI QAKLAAESGG
310 320 330 340 350
EIEGKEIKRK ITLFLDEIKK EEITVKYPTP AGKYLQEITA GRPIFSLPMA
360 370 380 390 400
IGGFRLRYGR SFATGFATSG IHPATMFLTY GFLAIGTQMR GERPKKSTIV
410 420 430 440 450
TPVTSLHPPI VKLKDGTVKK VHSVVEAIKI ANDVEEILFL GDILTAFGDW
460 470 480 490 500
LNEKANLVPS PYVEEWWIQE FDRAAMKKTD YKIEFDVMKP RKLFKIEGLE
510 520 530 540 550
NLSQYLGIPK DRLEEIIRKP FSRKPTIDEA ITISEKLGIP LHPEYTPFWV
560 570 580 590 600
HITKEELIKL IEELRKAKIQ NNKIYFHESQ KELKAILEKL FIEHFREGEY
610 620 630 640 650
FYINESMTKS LLYQLDNLNL EKAKKEFDNA IDALDLVNRL SPIEIRDVAG
660 670 680 690 700
VYVGFRAGRP EKAKMREMTG RPHGLFPVGE EGGKMRNVIE AYNKGYVKAE
710 720 730 740 750
FALYYCNHCK RYTIYRKCEV CGNKTKEVYV CKEIINRLKT SLFKQYKDWK
760 770 780 790 800
KVEEEIASHL WAEAVTHSKN NCREPKRYSL IKLNIKHYVD RAVQKLKLFN
810 820 830 840 850
IPKLVKGVRG TSNKDHIVER LEKAFLRSVS DVYVNKDGTI RYDGTQIPLT
860 870 880 890 900
HFRPKDLIGV TIEKLKELGY THDIYGNPLE REDQILQLKP QDIILPYGIL
910 920 930 940 950
VKSRLNKNKI VRTDAAEAFK KVANFVDEEL KRLYNLEPYY NIEKAEDLIG
960 970 980 990 1000
KIVFGIAPHT SAAVVGRIIG FTPIQGIIAH PIWHAGQRRN CDGDETAVML
1010 1020 1030 1040 1050
GLDALINFSR EYLPDKRGAR TMDAPLVLTL KLELKAVDDE VHDMDIVYNY
1060 1070 1080 1090 1100
PLEFYYETLK GSPAKDVKKQ CGILTLGDFL KEEDISKIPI GFTHPTKSIR
1110 1120 1130 1140 1150
LGNKVSLYKR LKTMQQKTEW QLKLAERIRA VDENIVAEIV IEKHFMPDIK
1160 1170 1180 1190 1200
GNLRGFSSQV FRCTKCDTTY DRVPLSGKCP KCGGNIVFTV HEGTIKKYLP
1210 1220 1230 1240
TSLYLARKYK IKKFTKQSLF LLDRRIKQIF GGEKKSLADF INS
Length:1,243
Mass (Da):142,593
Last modified:July 5, 2004 - v1
Checksum:iA48088166C1CF516
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017199 Genomic DNA. Translation: AAR39264.1.

Genome annotation databases

EnsemblBacteriaiAAR39264; AAR39264; NEQ420.
KEGGineq:NEQ420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017199 Genomic DNA. Translation: AAR39264.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228908.NEQ420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAR39264; AAR39264; NEQ420.
KEGGineq:NEQ420.

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Enzyme and pathway databases

BioCyciNEQU228908:GJB6-444-MONOMER.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch. 1 hit.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDP2L_NANEQ
AccessioniPrimary (citable) accession number: Q74N29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: November 11, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.