Q74N29 (DP2L_NANEQ) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 40.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: DNA polymerase II large subunit Short name=Pol II EC=2.7.7.7 | ||||
| Gene names |
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| Organism | Nanoarchaeum equitans (strain Kin4-M) | ||||
| Taxonomic identifier | 228908 [NCBI] | ||||
| Taxonomic lineage | Archaea › Nanoarchaeota › Nanoarchaeum |
Protein attributes
| Sequence length | 1243 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase By similarity. HAMAP MF_00324 |
| Catalytic activity | Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_00324 Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates. HAMAP MF_00324 |
| Subunit structure | Heterodimer of a large subunit and a small subunit By similarity. |
| Sequence similarities | Belongs to the archaeal DNA polymerase II family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Ligand | DNA-binding |
| Molecular function | DNA-directed DNA polymerase Exonuclease Hydrolase Nuclease Nucleotidyltransferase Transferase |
| Technical term | Complete proteome Multifunctional enzyme Reference proteome |
| Gene Ontology (GO) | |
| Biological process | DNA catabolic process Inferred from electronic annotation. Source: InterPro DNA replicationInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activityInferred from electronic annotation. Source: UniProtKB-KW exonuclease activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 1243 | 1243 | DNA polymerase II large subunit HAMAP MF_00324 | PRO_0000294697 | |||
Sequences
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References
| [1] | "The genome of Nanoarchaeum equitans: insights into early archaeal evolution and derived parasitism." Waters E., Hohn M.J., Ahel I., Graham D.E., Adams M.D., Barnstead M., Beeson K.Y., Bibbs L., Bolanos R., Keller M., Kretz K., Lin X., Mathur E., Ni J., Podar M., Richardson T., Sutton G.G., Simon M. Noorderwier M.Proc. Natl. Acad. Sci. U.S.A. 100:12984-12988(2003) [PubMed: 14566062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Kin4-M. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017199 Genomic DNA. Translation: AAR39264.1. |
| RefSeq | NP_963703.1. NC_005213.1. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2732644. |
| GenomeReviews | Gene locus NEQ420 in contig AE017199_GR. |
| KEGG | neq:NEQ420. |
Phylogenomic databases | |
| HOGENOM | HBG497074. |
| OMA | NCDGDED. |
| ProtClustDB | PRK04023. |
Family and domain databases | |
| HAMAP | MF_00324. DNApol_II_L_arch. [Tree] |
| InterPro | IPR004475. PolC_DP2. IPR016033. PolC_DP2_N. [Graphical view] |
| KO | K02322. |
| Pfam | PF03833. PolC_DP2. 1 hit. [Graphical view] |
| PIRSF | PIRSF016275. PolC_DP2. 1 hit. |
| TIGRFAMs | TIGR00354. PolC. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | DP2L_NANEQ | ||||||||
| Accession | Primary (citable) accession number: Q74N29 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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