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Q74MU5

- SYE_NANEQ

UniProt

Q74MU5 - SYE_NANEQ

Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Nanoarchaeum equitans (strain Kin4-M)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

    Catalytic activityi

    ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNEQU228908:GJB6-320-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
    Alternative name(s):
    Glutamyl-tRNA synthetaseUniRule annotation
    Short name:
    GluRSUniRule annotation
    Gene namesi
    Name:gltXUniRule annotation
    Ordered Locus Names:NEQ302
    OrganismiNanoarchaeum equitans (strain Kin4-M)
    Taxonomic identifieri228908 [NCBI]
    Taxonomic lineageiArchaeaNanoarchaeotaNanoarchaeum
    ProteomesiUP000000578: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Glutamate--tRNA ligasePRO_0000119723Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi228908.NEQ302.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74MU5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi90 – 10011"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000073585.
    KOiK01885.
    OMAiENDESKC.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00022_A. Glu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q74MU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKEIIAYLK LKYGKVKPQS VIGKIIAKNP ELKAKIKELI PIIEQEIKEV    50
    EQMDIEQIKE LAKAYEQTIE KKEKDIEIPV KDKVITRFAP NPSGLLHIGH 100
    ARAIVLNHYI AKKYNGQFIL RIEDTDPDVK KPMIEAYELI PKDVEWLIQE 150
    KPDKIVVQSD RLDIYYKYIE ELIKQGKAYV CLCKAEEFRE YRNKGLPCPH 200
    RNQSIEENLE LWSKMLKGEF KKGEAVVRLK TDLTHKDPGV RDFPIARIVE 250
    NPHPRIGYKP VFPLYNFAVV IDDHLLGITH VIRMKEHTNN AIKQSFIYKA 300
    FGWEEPIYLE YGALLTDMPT HKSEIRKLIE QKQIEGWDDI RLPTLIALRR 350
    RGILPEAIYE YIVKDVGLNK ADIKVDWNKI YYYHKIRIDK QTPRYFMIRD 400
    PIAIVIENYD DIIDKFEIKN GIPYKKISKH PDVDLGYREL PIKEVLYIDK 450
    RDAERLKQKP LRLFELFNIK FVGEIEIEYG DEYSKTKEKA YAVRVISFDV 500
    QEAIKNKYPI VQWLPEYEET TLFELDGYKK AYVEPNIKEN YVHFIREGYY 550
    KRENDKWIFS VK 562
    Length:562
    Mass (Da):66,631
    Last modified:July 5, 2004 - v1
    Checksum:i03E496D7DA5E6507
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017199 Genomic DNA. Translation: AAR39150.1.
    RefSeqiNP_963589.1. NC_005213.1.
    WP_011153291.1. NC_005213.1.

    Genome annotation databases

    EnsemblBacteriaiAAR39150; AAR39150; NEQ302.
    GeneIDi2654363.
    KEGGineq:NEQ302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017199 Genomic DNA. Translation: AAR39150.1 .
    RefSeqi NP_963589.1. NC_005213.1.
    WP_011153291.1. NC_005213.1.

    3D structure databases

    ProteinModelPortali Q74MU5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228908.NEQ302.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAR39150 ; AAR39150 ; NEQ302 .
    GeneIDi 2654363.
    KEGGi neq:NEQ302.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000073585.
    KOi K01885.
    OMAi ENDESKC.

    Enzyme and pathway databases

    BioCyci NEQU228908:GJB6-320-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00022_A. Glu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004526. Glu-tRNA-synth_arc/euk.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR022888. Glu_tRNA_synth_arc.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Kin4-M.

    Entry informationi

    Entry nameiSYE_NANEQ
    AccessioniPrimary (citable) accession number: Q74MU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3