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Protein

Nucleoside deoxyribosyltransferase

Gene

ntd

Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of the glycosidic bond of 2'-deoxyribonucleosides and the transfer of the deoxyribosyl moiety to an acceptor purine or pyrimidine base.By similarity

Catalytic activityi

2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901NucleophileBy similarity

GO - Molecular functioni

  1. deoxyribonucleoside 5'-monophosphate N-glycosidase activity Source: InterPro
  2. nucleoside deoxyribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside monophosphate catabolic process Source: InterPro
  2. nucleotide salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciLJOH257314:GJN3-130-MONOMER.
UniPathwayiUPA00312.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside deoxyribosyltransferase (EC:2.4.2.6)
Short name:
N-deoxyribosyltransferase
Gene namesi
Name:ntd
Ordered Locus Names:LJ_0124
OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Taxonomic identifieri257314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000581: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Nucleoside deoxyribosyltransferasePRO_0000220066Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257314.LJ0124.

Structurei

3D structure databases

ProteinModelPortaliQ74LQ9.
SMRiQ74LQ9. Positions 2-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3613.
KOiK08728.
OMAiPRYNFYD.
OrthoDBiEOG696C2B.

Family and domain databases

Gene3Di3.40.50.1810. 1 hit.
InterProiIPR007710. Nucleoside_deoxyribTrfase.
[Graphical view]
PfamiPF05014. Nuc_deoxyrib_tr. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74LQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGWFTETQN KAYKDAMSAL NANPTIDLEN SYVPLQNQYK DIRVDEHPEY
60 70 80 90 100
LHDKEWAQAT YNGDLVGIKT SDVMLGVYVP KEEDVGLGME LGYAMSQGKY
110 120 130 140
VLLVIPDELY GESINLMSWG VADNVIKMSE LATFDFNRPR YNFYDGAVY
Length:149
Mass (Da):16,941
Last modified:July 5, 2004 - v1
Checksum:i6CE8A86B0553152A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017198 Genomic DNA. Translation: AAS08106.1.
RefSeqiNP_964140.1. NC_005362.1.

Genome annotation databases

EnsemblBacteriaiAAS08106; AAS08106; LJ_0124.
GeneIDi2743002.
KEGGiljo:LJ0124.
PATRICi22236872. VBILacJoh1832_0133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017198 Genomic DNA. Translation: AAS08106.1.
RefSeqiNP_964140.1. NC_005362.1.

3D structure databases

ProteinModelPortaliQ74LQ9.
SMRiQ74LQ9. Positions 2-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257314.LJ0124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS08106; AAS08106; LJ_0124.
GeneIDi2743002.
KEGGiljo:LJ0124.
PATRICi22236872. VBILacJoh1832_0133.

Phylogenomic databases

eggNOGiCOG3613.
KOiK08728.
OMAiPRYNFYD.
OrthoDBiEOG696C2B.

Enzyme and pathway databases

UniPathwayiUPA00312.
BioCyciLJOH257314:GJN3-130-MONOMER.

Family and domain databases

Gene3Di3.40.50.1810. 1 hit.
InterProiIPR007710. Nucleoside_deoxyribTrfase.
[Graphical view]
PfamiPF05014. Nuc_deoxyrib_tr. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNCM I-1225 / La1 / NCC 533.

Entry informationi

Entry nameiNTD_LACJO
AccessioniPrimary (citable) accession number: Q74LQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.