Reviewed, UniProtKB/Swiss-Prot Q74L45 (GPMA2_LACJO)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2
      Short name=Phosphoglyceromutase 2
      Short name=PGAM 2
      Short name=BPG-dependent PGAM 2
      Short name=dPGM 2
    EC=5.4.2.1

Gene names

Name:	gpmA2
Ordered Locus Names:	LJ_0380

Organism

Lactobacillus johnsonii [Complete proteome] [HAMAP]

Taxonomic identifier

33959 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 HAMAP MF_01039		PRO_0000179884
Sites
	Active site	13	1	Tele-phosphohistidine intermediate By similarity
	Active site	182	1	By similarity
	Site	65	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q74L45-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 11E2135674109A56	FASTA	229	26,212
	10 20 30 40 50 60 MKRKLAKLVL VRHGESVANR DNVYTGWNDV PLSKKGIAQA KNAGLKVEKI AEFAPTHIHT 70 80 90 100 110 120 SVLSRAIMTA NIIADVCSFL YLPITKTWRL NERHYGALRG INKDVSKKIF GTNQVLEWRR 130 140 150 160 170 180 GFDSVPPLLT QPVQDRRYQK YDMRLMPQGE SLHQTQERLM PYFWDHIAPE LMAGHDQLVV 190 200 210 220 AHGSSLRALI KKIEDISNED IVKVEVPNAE PIVYTFDTDL HIVKKEILH

References

[1]

"The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533." Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C., Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R., Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A. Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004) [PubMed: 14983040] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 533.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017198 Genomic DNA. Translation: AAS08370.1.
RefSeq	NP_964404.1.
3D structure databases
SMR	Q74L45. Positions 6-228.
ModBase	Search...
Genome annotation databases
GeneID	2741990.
GenomeReviews	Gene locus LJ_0380 in contig AE017198_GR.
KEGG	ljo:LJ0380.
NMPDR	fig|257314.1.peg.390.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG658938.
OMA	YTGWSDV.
Enzyme and pathway databases
BioCyc	LJOH257314:LJ_0380-MONOMER.
BRENDA	5.4.2.1. 141476.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA. [Tree]
InterPro	IPR001345. PG/BPGM_mutase_AS. IPR013078. PG_mutase. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. PGAM. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA2_LACJO

Accession

Primary (citable) accession number: Q74L45

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)