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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei288Proton donorUniRule annotation1
Active sitei309UniRule annotation1
Active sitei423UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:LJ_0924
OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Taxonomic identifieri257314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000581 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806581 – 447Glucose-6-phosphate isomeraseAdd BLAST447

Interactioni

Protein-protein interaction databases

STRINGi257314.LJ0924.

Structurei

3D structure databases

ProteinModelPortaliQ74K31.
SMRiQ74K31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
KOiK01810.
OMAiNNIGEDY.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74K31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKVVHFDAS KLTPFVHENE LKEMQAMVTA ADQELREGTG AGSDFRGWID
60 70 80 90 100
LPINYDKDEF DRIKKAAKKI QNDSEVLVGI GIGGSYLGAQ ASIEFLNSSF
110 120 130 140 150
YGREKEKYPT VVFCGNSLSG SYLYDLLEWL GDKDFSINII SKSGTTTEPS
160 170 180 190 200
IAFRVLKDKL IKKYGKEEAA KRIYATTDRA KGALKTEADA EGYEEFVVPD
210 220 230 240 250
DIGGRFSVLS AVGLLPIAVA GGDIDAMMKG AADARAAYTD PDVLKDSPYQ
260 270 280 290 300
YAAMRNILYR KGYTTELLEN YEPSLRMFGE WWKQLMGESE GKDQKGIYPS
310 320 330 340 350
SANFTTDLHS LGQYIQEGRR NLMETVIRVE HPTHDVTIPD DKENLDQLNF
360 370 380 390 400
LSGKTMNYVN DRAYEGVVLA HTDGGVPVMT VDIENQTAHT LGYLIYWFEL
410 420 430 440
AVGISGYLNG INPFNQPGVE SYKRNMFGLL NKPGYEDLHD DLTKRLK
Length:447
Mass (Da):49,910
Last modified:July 5, 2004 - v1
Checksum:i80AF7428EC3F69F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017198 Genomic DNA. Translation: AAS08745.1.
RefSeqiWP_004897655.1. NC_005362.1.

Genome annotation databases

EnsemblBacteriaiAAS08745; AAS08745; LJ_0924.
KEGGiljo:LJ_0924.

Similar proteinsi

Entry informationi

Entry nameiG6PI_LACJO
AccessioniPrimary (citable) accession number: Q74K31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families