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Q74K31 (G6PI_LACJO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:LJ_0924
OrganismLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) [Complete proteome] [HAMAP]
Taxonomic identifier257314 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180658

Sites

Active site2881Proton donor By similarity
Active site3091 By similarity
Active site4231 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q74K31 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 80AF7428EC3F69F5

FASTA44749,910
        10         20         30         40         50         60 
MSKVVHFDAS KLTPFVHENE LKEMQAMVTA ADQELREGTG AGSDFRGWID LPINYDKDEF 

        70         80         90        100        110        120 
DRIKKAAKKI QNDSEVLVGI GIGGSYLGAQ ASIEFLNSSF YGREKEKYPT VVFCGNSLSG 

       130        140        150        160        170        180 
SYLYDLLEWL GDKDFSINII SKSGTTTEPS IAFRVLKDKL IKKYGKEEAA KRIYATTDRA 

       190        200        210        220        230        240 
KGALKTEADA EGYEEFVVPD DIGGRFSVLS AVGLLPIAVA GGDIDAMMKG AADARAAYTD 

       250        260        270        280        290        300 
PDVLKDSPYQ YAAMRNILYR KGYTTELLEN YEPSLRMFGE WWKQLMGESE GKDQKGIYPS 

       310        320        330        340        350        360 
SANFTTDLHS LGQYIQEGRR NLMETVIRVE HPTHDVTIPD DKENLDQLNF LSGKTMNYVN 

       370        380        390        400        410        420 
DRAYEGVVLA HTDGGVPVMT VDIENQTAHT LGYLIYWFEL AVGISGYLNG INPFNQPGVE 

       430        440 
SYKRNMFGLL NKPGYEDLHD DLTKRLK 

« Hide

References

[1]"The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533."
Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C., Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R., Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.
Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CNCM I-1225 / La1 / NCC 533.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017198 Genomic DNA. Translation: AAS08745.1.
RefSeqNP_964779.1. NC_005362.1.

3D structure databases

ProteinModelPortalQ74K31.
SMRQ74K31. Positions 5-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257314.LJ0924.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS08745; AAS08745; LJ_0924.
GeneID2742521.
KEGGljo:LJ0924.
PATRIC22238202. VBILacJoh1832_0781.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMAGVESYKR.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycLJOH257314:GJN3-786-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_LACJO
AccessionPrimary (citable) accession number: Q74K31
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways