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Q74K26

- KITH_LACJO

UniProt

Q74K26 - KITH_LACJO

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Protein
Thymidine kinase
Gene
tdk, LJ_0929
Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptor Reviewed prediction
Metal bindingi151 – 1511Zinc By similarity
Metal bindingi154 – 1541Zinc By similarity
Metal bindingi188 – 1881Zinc By similarity
Metal bindingi191 – 1911Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarity
Nucleotide bindingi93 – 964ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciLJOH257314:GJN3-793-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:LJ_0929
OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Taxonomic identifieri257314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000581: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Thymidine kinaseUniRule annotation
PRO_0000174982Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257314.LJ0929.

Structurei

3D structure databases

ProteinModelPortaliQ74K26.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
KOiK00857.
OMAiEGRIRHE.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74K26-1 [UniParc]FASTAAdd to Basket

« Hide

MAQLFFRYGA MSSGKSIEIL KVAHNYEAQG RKIALMTSNV DDRSGVGTVA    50
SRIGLHRKAV PISEDLDLFN YVSELNKSDV ESGNGRVACV LIDEAQFLKR 100
HHVLECAKIV DELKIPVMAF GLKNDFQNHL FEGSENLLIF ADKVEEMKTI 150
CHYCGHKATM NLRINSGKPV YEGEQVQIGG DESYYPVCRF HYFHPNKQR 199
Length:199
Mass (Da):22,485
Last modified:July 5, 2004 - v1
Checksum:i8B949E8A5A6B6021
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017198 Genomic DNA. Translation: AAS08750.1.
RefSeqiNP_964784.1. NC_005362.1.

Genome annotation databases

EnsemblBacteriaiAAS08750; AAS08750; LJ_0929.
GeneIDi2742371.
KEGGiljo:LJ0929.
PATRICi22238216. VBILacJoh1832_0786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017198 Genomic DNA. Translation: AAS08750.1 .
RefSeqi NP_964784.1. NC_005362.1.

3D structure databases

ProteinModelPortali Q74K26.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257314.LJ0929.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS08750 ; AAS08750 ; LJ_0929 .
GeneIDi 2742371.
KEGGi ljo:LJ0929.
PATRICi 22238216. VBILacJoh1832_0786.

Phylogenomic databases

eggNOGi COG1435.
KOi K00857.
OMAi EGRIRHE.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci LJOH257314:GJN3-793-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNCM I-1225 / La1 / NCC 533.

Entry informationi

Entry nameiKITH_LACJO
AccessioniPrimary (citable) accession number: Q74K26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi