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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140GTPUniRule annotation1
Binding sitei144GTPUniRule annotation1
Binding sitei188GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 26GTPUniRule annotation5
Nucleotide bindingi109 – 111GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:LJ_0975
OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Taxonomic identifieri257314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000581 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001143581 – 458Cell division protein FtsZAdd BLAST458

Proteomic databases

PRIDEiQ74JY1

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi257314.LJ0975

Structurei

3D structure databases

ProteinModelPortaliQ74JY1
SMRiQ74JY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK Bacteria
COG0206 LUCA
KOiK03531
OMAiMRAVKGI

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q74JY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTFDSDDN KNAVIKVIGV GGAGGNAVNR MIDEGVQGVS FIAANTDVQA
60 70 80 90 100
LNSNKAENKI QLGPKLTRGL GAGSHPEVGQ KAAEESQQTI EDSLKGADMI
110 120 130 140 150
FITAGMGGGT GTGAAPVIAK IARETGALTV GVVTRPFTFE GPKRSKNAAE
160 170 180 190 200
GIAQLKQYVD TLVIIANNRL LEMVDKKTPM MDAFKEADNV LRQGVQGISD
210 220 230 240 250
LITSTDYVNL DFADVKTVME NQGAALMGIG RASGENRTVE ATKLAISSPL
260 270 280 290 300
LEVSIDGAKQ VLLNITGGPD LTLFEAQDAS DIVSKAAGDG VNIIFGTSIN
310 320 330 340 350
ANLGDEVVVT VIATGIDSKA EEEASKQPMR RPSRPARQEV VTPEPTKSEQ
360 370 380 390 400
PEVSKAASVD DTEVKVANTI SHEAPTQSIP EVKAEKKESQ DTLLDPTSVW
410 420 430 440 450
KQDRKENNRP QPVENKEKDD DEFDSFSSDD STSISQIETS VDDESDNDIP

FFKHRRQD
Length:458
Mass (Da):48,861
Last modified:July 5, 2004 - v1
Checksum:i45D4219AAE875764
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017198 Genomic DNA Translation: AAS08796.1
RefSeqiWP_011161844.1, NC_005362.1

Genome annotation databases

EnsemblBacteriaiAAS08796; AAS08796; LJ_0975
KEGGiljo:LJ_0975

Similar proteinsi

Entry informationi

Entry nameiFTSZ_LACJO
AccessioniPrimary (citable) accession number: Q74JY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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