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Q74JC1

- FTHS_LACJO

UniProt

Q74JC1 - FTHS_LACJO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLJOH257314:GJN3-1052-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LJ_1188
    OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
    Taxonomic identifieri257314 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000581: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000199353Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257314.LJ1188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74JC1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiGIEHEAS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q74JC1-1 [UniParc]FASTAAdd to Basket

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    MKSDIEIAQD TKELPITEIA KKVDLQPDEI ELYGNDKAKI SWKGINRIKQ    50
    GKKLGKLILV TSISPTPAGE GKSTITIGLG DAISNQLHKN TLIALREPSM 100
    GPVFGLKGGA TGGGYAQIIT MEDINLHFTG DMHALTSAID TLAALVDNYI 150
    YQDNSLELDP NRILLKRGID VNDRTLRKIT IGQGSRFNGI EHEASFAITV 200
    ANELMAILCL ATDIDDLKKR IGNMLVGFSV KDEPVYVKDL GFEGAIAALL 250
    STALKPNLVQ TLEHTPAIVH GGPFANIAHG ANSVIATNTA LHLSDYVLTE 300
    AGFGADLGGQ KFMDFVSNHL DKRPDAVVVV ATVRALKYQA EETTDHLDEE 350
    NIPALEKGFE NLKRHMENMA HYGVPVIVLI NKFASDTEQE LSKLKELVKA 400
    DGFECEVVSY HDEGSKGGIK AAEKVVELTN KASDFTSVYE PTDSVEEKIS 450
    KIAHNIYHAK DIEYSDKAKD QLAEIKKMGK DNLPVIMAKT QYSFTDKKSI 500
    LGAPKDFTLH VKNLALKNGA GFIVVATGSI LDMPGLPKYP AALDIDVDNN 550
    GKISGLF 557
    Length:557
    Mass (Da):60,475
    Last modified:July 5, 2004 - v1
    Checksum:i7E615C183F9F3393
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017198 Genomic DNA. Translation: AAS09009.1.
    RefSeqiNP_965043.1. NC_005362.1.

    Genome annotation databases

    EnsemblBacteriaiAAS09009; AAS09009; LJ_1188.
    GeneIDi2742818.
    KEGGiljo:LJ1188.
    PATRICi22238753. VBILacJoh1832_1054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017198 Genomic DNA. Translation: AAS09009.1 .
    RefSeqi NP_965043.1. NC_005362.1.

    3D structure databases

    ProteinModelPortali Q74JC1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257314.LJ1188.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS09009 ; AAS09009 ; LJ_1188 .
    GeneIDi 2742818.
    KEGGi ljo:LJ1188.
    PATRICi 22238753. VBILacJoh1832_1054.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi GIEHEAS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LJOH257314:GJN3-1052-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CNCM I-1225 / La1 / NCC 533.

    Entry informationi

    Entry nameiFTHS_LACJO
    AccessioniPrimary (citable) accession number: Q74JC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3