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Q74HC3

- DGK1_LACJO

UniProt

Q74HC3 - DGK1_LACJO

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Protein
Deoxyadenosine kinase
Gene
LJ_1824
Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism.

Catalytic activityi

ATP + deoxyadenosine = ADP + dAMP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321Substrate By similarity
Binding sitei44 – 441Substrate By similarity
Binding sitei55 – 551Substrate By similarity
Active sitei78 – 781Proton acceptor Reviewed prediction
Binding sitei79 – 791Substrate By similarity
Binding sitei84 – 841Substrate By similarity
Binding sitei149 – 1491Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. deoxyadenosine kinase activity Source: UniProtKB-EC
  3. phosphotransferase activity, alcohol group as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLJOH257314:GJN3-1886-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyadenosine kinase (EC:2.7.1.76)
Short name:
DADO kinase
Short name:
DAK
Alternative name(s):
Deoxynucleoside kinase complex I S-component
Gene namesi
Ordered Locus Names:LJ_1824
OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Taxonomic identifieri257314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000581: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 215214Deoxyadenosine kinase
PRO_0000239236Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a deoxyadenosine (DAK) and a deoxyguanosine kinase (DGK).

Protein-protein interaction databases

STRINGi257314.LJ1824.

Structurei

3D structure databases

ProteinModelPortaliQ74HC3.

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.

Phylogenomic databases

eggNOGiCOG1428.
OMAiLLIYIHV.
OrthoDBiEOG628F9B.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000705. DNK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q74HC3-1 [UniParc]FASTAAdd to Basket

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MTVIVLSGPI GAGKSSLTSL LAEHLGTQAF YEGVDNNPIL PLYYKDMAHY    50
TFLLNTYLLN HRLAQINQAI RDHNSVSDRS IYEDALFFKM NVDSGIADPT 100
EFKIYDSLLE NMMEQAPGNP SKKPDLLIYI HVSLDTMLHR IQKRGRKFEQ 150
LSTDPSLKDY YARLLSYYEP WYEKYNASPK MMIDGDKYDF VANEDARRKV 200
INAIDQKLID IGNLN 215
Length:215
Mass (Da):24,696
Last modified:January 23, 2007 - v3
Checksum:i5D19BF68370C1F96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01881 Genomic DNA. Translation: AAB09750.1.
AE017198 Genomic DNA. Translation: AAS09769.1.
PIRiA56168.
RefSeqiNP_965803.1. NC_005362.1.

Genome annotation databases

EnsemblBacteriaiAAS09769; AAS09769; LJ_1824.
GeneIDi2742213.
KEGGiljo:LJ1824.
PATRICi22240444. VBILacJoh1832_1825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01881 Genomic DNA. Translation: AAB09750.1 .
AE017198 Genomic DNA. Translation: AAS09769.1 .
PIRi A56168.
RefSeqi NP_965803.1. NC_005362.1.

3D structure databases

ProteinModelPortali Q74HC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257314.LJ1824.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS09769 ; AAS09769 ; LJ_1824 .
GeneIDi 2742213.
KEGGi ljo:LJ1824.
PATRICi 22240444. VBILacJoh1832_1825.

Phylogenomic databases

eggNOGi COG1428.
OMAi LLIYIHV.
OrthoDBi EOG628F9B.

Enzyme and pathway databases

BioCyci LJOH257314:GJN3-1886-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000705. DNK. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the heterodimeric deoxyguanosine kinase/deoxyadenosine kinase of Lactobacillus acidophilus R-26."
    Ma G.T., Hong Y.S., Ives D.H.
    J. Biol. Chem. 270:6595-6601(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11506 / JCM 1101 / NBRC 13952 / NCIMB 8795 / R-26 / VPI 11088.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CNCM I-1225 / La1 / NCC 533.
  3. "Heterodimeric deoxynucleoside kinases of Lactobacillus acidophilus R-26: functional assignment of subunits using limited proteolysis controlled by end-product inhibitors."
    Ikeda S., Ma G.T., Ives D.H.
    Biochemistry 33:5328-5334(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-38.
    Strain: ATCC 11506 / JCM 1101 / NBRC 13952 / NCIMB 8795 / R-26 / VPI 11088.

Entry informationi

Entry nameiDGK1_LACJO
AccessioniPrimary (citable) accession number: Q74HC3
Secondary accession number(s): Q59483, Q5FHT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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