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Q74H89 (Q74H89_GEOSL) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA gyrase subunit B RuleBase RU003363 HAMAP MF_01898
EC=5.99.1.3 RuleBase RU003363 HAMAP MF_01898
Gene names
Name:gyrB HAMAP MF_01898 EMBL AAR33338.1
Ordered Locus Names:GSU0003
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length795 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. RuleBase RU003363 HAMAP MF_01898

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS002288 RuleBase RU003363 HAMAP MF_01898

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01898

Subcellular location

Cytoplasm By similarity HAMAP MF_01898.

Sequence similarities

Belongs to the type II topoisomerase family. HAMAP MF_01898 RuleBase RU000380

Sequences

Sequence LengthMass (Da)Tools
Q74H89 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 339280BF763576DB

FASTA79588,786
        10         20         30         40         50         60 
MTDEQNYDYG ADKIKVLEGL EAVRKRPAMY IGSTAAQGLH HLVYEIVDNS IDEALAGYCN 

        70         80         90        100        110        120 
EVNVTIHLDG SLTVVDNGRG IPTDIHPTEG KPAAEVALTV LHAGGKFDNT SYKVSGGLHG 

       130        140        150        160        170        180 
VGVSVVNALS RKLELEIRRD GKVYRQSYAC GDPQTPLEVM GETKKRGTKI TFLPDDTIFE 

       190        200        210        220        230        240 
TTEFSFDVLS QRLRELAFLN AGVRITITDE REEGKHHDFH YEGGIVSFVE YLNRNRTALH 

       250        260        270        280        290        300 
PKPIYFKGEK AGVEMEVALQ YNDSYDEKVF SFANNINTHE GGTHLVGFRA ALTRTMNTYA 

       310        320        330        340        350        360 
AANELLKKEK VAISGEDLRE GLTAVISVKI PQPQFEGQTK TKLGNSEVKG YVESLMNEKL 

       370        380        390        400        410        420 
AVFLEENPKI AKDIIGKSIE AARAREAARK ARELTRRKGA LDISNLPGKL ADCQERDPAL 

       430        440        450        460        470        480 
CELYLVEGDS AGGSAKQGRD RKFQAILPLK GKILNVEKAR FDKMLSSQEI GTLITALGTG 

       490        500        510        520        530        540 
IGKDDFDIAK LRYHRIIVMT DADVDGSHIL TLLLTFFFRQ MPEVVERGHL YIAQPPLYKV 

       550        560        570        580        590        600 
KRGRKELYLR NEAAMQAYLL EEGTEDMLLF LESGEKTYSG KQIIPILKQL VEYRTILDKV 

       610        620        630        640        650        660 
VRKGINEELI RVFLRLGVKG GIEDMEQLVP FLTNISRVYD GGDFSPLDDG RVIVRLGNLR 

       670        680        690        700        710        720 
IALDQHTLDL IGSYEYGLLV ESYRKVRDIF GDGRAVVSSE GKELFATTIG LDLLSFFMDS 

       730        740        750        760        770        780 
AKKGLSIQRY KGLGEMNPEQ LWETTMEPVN RTLLQVKIED AIEADTIFTI LMGDQVEPRR 

       790 
DFIEQNALNV SNLDI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017180 Genomic DNA. Translation: AAR33338.1.
RefSeqNP_951065.1. NC_002939.4.

3D structure databases

HSSPHSSP built from PDB template 1AJ6 based on UniProtKB P06982.
ProteinModelPortalQ74H89.
SMRQ74H89. Positions 14-380.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2686080.
GenomeReviewsGene locus GSU0003 in contig AE017180_GR.
KEGGgsu:GSU0003.
NMPDRfig|243231.1.peg.3.
PATRIC22022743. VBIGeoSul17553_0004.
TIGRGSU0003.

Phylogenomic databases

HOGENOMHBG304889.
OMADCSSRDP.
PhylomeDBQ74H89.
ProtClustDBPRK14939.

Family and domain databases

HAMAPMF_01898. GyrB.
[Tree]
InterProIPR003594. ATPase-like_ATP-bd.
IPR011557. GyrB.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013759. Topo_IIA_B/N_ab.
IPR002288. Topo_IIA_B_C.
IPR013506. Topo_IIA_bsu_dom2.
IPR013760. Topo_IIA_cen.
IPR018522. TopoIIA_CS.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
G3DSA:3.40.50.670. Topo_IIA_B/N_ab. 2 hits.
KOK02470.
PfamPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
PRINTSPR00418. TPI2FAMILY.
SMARTSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMSSF55874. ATP_bd_ATPase. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01059. GyrB. 1 hit.
PROSITEPS00177. TOPOISOMERASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ74H89_GEOSL
AccessionPrimary (citable) accession number: Q74H89
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info