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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei604For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-311-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:GSU0270
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353352 – 609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST608

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU0270

Structurei

3D structure databases

ProteinModelPortaliQ74GH6
SMRiQ74GH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini286 – 425SIS 1UniRule annotationAdd BLAST140
Domaini458 – 599SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258898
InParanoidiQ74GH6
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q74GH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGA QEATPIILDG LKRLEYRGYD SAGICTLLEG KADKRRSEGK
60 70 80 90 100
LINLERLIQS TPLAGRIGIG HTRWATHGPP SERNAHPHQA GSIIVVHNGI
110 120 130 140 150
IENYLELKQR LVTSGRVFNS DTDTEVIAHL IDDKFAGTGD FERAVREALA
160 170 180 190 200
EVRGAYALCI LCEREPGVLI AAKQGSPMVV GLGEGEFFVA SDIPAILSHT
210 220 230 240 250
REMVFMEDGE IVVFRDGHPT FSTVAGAPLD KKSRHIDWSP LMAEKGGYKH
260 270 280 290 300
FMLKEIFEQP RAVQDTITGR LLEEQGDVRL EEMKLADEQL RGIGRICIVA
310 320 330 340 350
CGTSWHSALV GKFLMEEHCR IPVEVDIASE FRYRNPVIDS KTLLLVISQS
360 370 380 390 400
GETADTLAAL REAKARGAMT AAICNVVDSS IAREAHGVLY THAGPEIGVA
410 420 430 440 450
STKAFVTQLV ALYLFTIRLG RAVGTIDCEQ GRTMIGGLLK VPALLEQALE
460 470 480 490 500
TNEQVERIAR RYMNARDFLY LGRGMNYPIA LEGALKLKEI SYIHAEGYPA
510 520 530 540 550
GEMKHGPIAL IDENMPVVVL VPKNSTYEKV LSNMEEVIAR GGRVIAICSA
560 570 580 590 600
GDEAIAKKAE VTLEVPTDGE ELAPIILSVP LQLLAYHVAV LKGTDVDQPR

NLAKSVTVE
Length:609
Mass (Da):66,459
Last modified:January 23, 2007 - v3
Checksum:i405FD7F70E309D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR33604.1
RefSeqiNP_951331.1, NC_002939.5
WP_010940943.1, NC_002939.5

Genome annotation databases

EnsemblBacteriaiAAR33604; AAR33604; GSU0270
GeneIDi2687531
KEGGigsu:GSU0270
PATRICifig|243231.5.peg.269

Similar proteinsi

Entry informationi

Entry nameiGLMS_GEOSL
AccessioniPrimary (citable) accession number: Q74GH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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