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Q74GH6

- GLMS_GEOSL

UniProt

Q74GH6 - GLMS_GEOSL

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, GSU0270
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei604 – 6041For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciGSUL243231:GH27-274-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:GSU0270
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135335Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU0270.

Structurei

3D structure databases

ProteinModelPortaliQ74GH6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2
Add
BLAST
Domaini286 – 425140SIS 1
Add
BLAST
Domaini458 – 599142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSAGICTL.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q74GH6-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYIGA QEATPIILDG LKRLEYRGYD SAGICTLLEG KADKRRSEGK    50
LINLERLIQS TPLAGRIGIG HTRWATHGPP SERNAHPHQA GSIIVVHNGI 100
IENYLELKQR LVTSGRVFNS DTDTEVIAHL IDDKFAGTGD FERAVREALA 150
EVRGAYALCI LCEREPGVLI AAKQGSPMVV GLGEGEFFVA SDIPAILSHT 200
REMVFMEDGE IVVFRDGHPT FSTVAGAPLD KKSRHIDWSP LMAEKGGYKH 250
FMLKEIFEQP RAVQDTITGR LLEEQGDVRL EEMKLADEQL RGIGRICIVA 300
CGTSWHSALV GKFLMEEHCR IPVEVDIASE FRYRNPVIDS KTLLLVISQS 350
GETADTLAAL REAKARGAMT AAICNVVDSS IAREAHGVLY THAGPEIGVA 400
STKAFVTQLV ALYLFTIRLG RAVGTIDCEQ GRTMIGGLLK VPALLEQALE 450
TNEQVERIAR RYMNARDFLY LGRGMNYPIA LEGALKLKEI SYIHAEGYPA 500
GEMKHGPIAL IDENMPVVVL VPKNSTYEKV LSNMEEVIAR GGRVIAICSA 550
GDEAIAKKAE VTLEVPTDGE ELAPIILSVP LQLLAYHVAV LKGTDVDQPR 600
NLAKSVTVE 609
Length:609
Mass (Da):66,459
Last modified:January 23, 2007 - v3
Checksum:i405FD7F70E309D4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33604.1.
RefSeqiNP_951331.1. NC_002939.5.
WP_010940943.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR33604; AAR33604; GSU0270.
GeneIDi2687531.
KEGGigsu:GSU0270.
PATRICi22023284. VBIGeoSul17553_0269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33604.1 .
RefSeqi NP_951331.1. NC_002939.5.
WP_010940943.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q74GH6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243231.GSU0270.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR33604 ; AAR33604 ; GSU0270 .
GeneIDi 2687531.
KEGGi gsu:GSU0270.
PATRICi 22023284. VBIGeoSul17553_0269.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi SAGICTL.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci GSUL243231:GH27-274-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiGLMS_GEOSL
AccessioniPrimary (citable) accession number: Q74GH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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