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Q74FW8

- GCH4_GEOSL

UniProt

Q74FW8 - GCH4_GEOSL

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei144 – 1441May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciGSUL243231:GH27-489-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:GSU0484
    OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
    Taxonomic identifieri243231 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000000577: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258GTP cyclohydrolase FolE2PRO_0000147710Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243231.GSU0484.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74FW8.
    SMRiQ74FW8. Positions 12-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q74FW8-1 [UniParc]FASTAAdd to Basket

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    MPDMQTSRDT RKIPISKVGV KDISYPIVVM DKNRKFQQTV ARVNMYVDLP    50
    HHFKGTHMSR FIEILNAYRE DIALDKMEPI LQEMKKKLGA SSAHLEIEFP 100
    YFIEKRAPVS GARSLMEYTC TFTGTLAETF DFVLGVQVPV TSLCPCSKEL 150
    SRYGAHNQRS HITVRVRYAG FVWIEELVEL IEGCGSSPVW SLLKRADEKF 200
    VTERAYENPK FVEDIVREAT LALAAHEAIT WFSVEAENFE SIHKHSAYAA 250
    IEQDKRKA 258
    Length:258
    Mass (Da):29,522
    Last modified:July 5, 2004 - v1
    Checksum:i535E194C25AB1C4A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR33816.1.
    RefSeqiNP_951543.3. NC_002939.5.

    Genome annotation databases

    EnsemblBacteriaiAAR33816; AAR33816; GSU0484.
    GeneIDi2686189.
    KEGGigsu:GSU0484.
    PATRICi22023719. VBIGeoSul17553_0483.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR33816.1 .
    RefSeqi NP_951543.3. NC_002939.5.

    3D structure databases

    ProteinModelPortali Q74FW8.
    SMRi Q74FW8. Positions 12-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243231.GSU0484.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAR33816 ; AAR33816 ; GSU0484 .
    GeneIDi 2686189.
    KEGGi gsu:GSU0484.
    PATRICi 22023719. VBIGeoSul17553_0483.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci GSUL243231:GH27-489-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51573 / DSM 12127 / PCA.

    Entry informationi

    Entry nameiGCH4_GEOSL
    AccessioniPrimary (citable) accession number: Q74FW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3