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Q74FW8

- GCH4_GEOSL

UniProt

Q74FW8 - GCH4_GEOSL

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei144 – 1441May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciGSUL243231:GH27-489-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:GSU0484
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258GTP cyclohydrolase FolE2PRO_0000147710Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU0484.

Structurei

3D structure databases

ProteinModelPortaliQ74FW8.
SMRiQ74FW8. Positions 12-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
InParanoidiQ74FW8.
KOiK09007.
OMAiDVQSSRD.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74FW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDMQTSRDT RKIPISKVGV KDISYPIVVM DKNRKFQQTV ARVNMYVDLP
60 70 80 90 100
HHFKGTHMSR FIEILNAYRE DIALDKMEPI LQEMKKKLGA SSAHLEIEFP
110 120 130 140 150
YFIEKRAPVS GARSLMEYTC TFTGTLAETF DFVLGVQVPV TSLCPCSKEL
160 170 180 190 200
SRYGAHNQRS HITVRVRYAG FVWIEELVEL IEGCGSSPVW SLLKRADEKF
210 220 230 240 250
VTERAYENPK FVEDIVREAT LALAAHEAIT WFSVEAENFE SIHKHSAYAA

IEQDKRKA
Length:258
Mass (Da):29,522
Last modified:July 5, 2004 - v1
Checksum:i535E194C25AB1C4A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33816.1.
RefSeqiNP_951543.3. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR33816; AAR33816; GSU0484.
GeneIDi2686189.
KEGGigsu:GSU0484.
PATRICi22023719. VBIGeoSul17553_0483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33816.1 .
RefSeqi NP_951543.3. NC_002939.5.

3D structure databases

ProteinModelPortali Q74FW8.
SMRi Q74FW8. Positions 12-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU0484.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR33816 ; AAR33816 ; GSU0484 .
GeneIDi 2686189.
KEGGi gsu:GSU0484.
PATRICi 22023719. VBIGeoSul17553_0483.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
InParanoidi Q74FW8.
KOi K09007.
OMAi DVQSSRD.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci GSUL243231:GH27-489-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiGCH4_GEOSL
AccessioniPrimary (citable) accession number: Q74FW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3