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Q74FW8 (GCH4_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:GSU0484
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147710

Sites

Site1441May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q74FW8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 535E194C25AB1C4A

FASTA25829,522
        10         20         30         40         50         60 
MPDMQTSRDT RKIPISKVGV KDISYPIVVM DKNRKFQQTV ARVNMYVDLP HHFKGTHMSR 

        70         80         90        100        110        120 
FIEILNAYRE DIALDKMEPI LQEMKKKLGA SSAHLEIEFP YFIEKRAPVS GARSLMEYTC 

       130        140        150        160        170        180 
TFTGTLAETF DFVLGVQVPV TSLCPCSKEL SRYGAHNQRS HITVRVRYAG FVWIEELVEL 

       190        200        210        220        230        240 
IEGCGSSPVW SLLKRADEKF VTERAYENPK FVEDIVREAT LALAAHEAIT WFSVEAENFE 

       250 
SIHKHSAYAA IEQDKRKA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017180 Genomic DNA. Translation: AAR33816.1.
RefSeqNP_951543.3. NC_002939.5.

3D structure databases

ProteinModelPortalQ74FW8.
SMRQ74FW8. Positions 12-255.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243231.GSU0484.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR33816; AAR33816; GSU0484.
GeneID2686189.
KEGGgsu:GSU0484.
PATRIC22023719. VBIGeoSul17553_0483.

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycGSUL243231:GH27-489-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_GEOSL
AccessionPrimary (citable) accession number: Q74FW8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways