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Protein
Submitted name:

TrkA domain protein

Gene

GSU0527

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46GlucoseCombined sources1
Metal bindingi183Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi183Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi210Calcium 1Combined sources1
Metal bindingi210Calcium 2Combined sources1
Metal bindingi214Calcium 1Combined sources1
Metal bindingi214Calcium 2Combined sources1
Binding sitei249GlucoseCombined sources1
Metal bindingi359Zinc; via tele nitrogenCombined sources1
Binding sitei361NADCombined sources1
Metal bindingi364ZincCombined sources1
Binding sitei372GlucoseCombined sources1
Binding sitei381AMPCombined sources1
Metal bindingi388ZincCombined sources1
Metal bindingi391Zinc; via pros nitrogenCombined sources1
Binding sitei418ADP; via carbonyl oxygenCombined sources1
Binding sitei420AMPCombined sources1
Binding sitei420NAD; via amide nitrogenCombined sources1
Binding sitei444ADPCombined sources1
Binding sitei444AMPCombined sources1
Binding sitei444NADCombined sources1
Metal bindingi449Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi449Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi450Calcium 2Combined sources1
Metal bindingi450Calcium 3Combined sources1
Metal bindingi453Calcium 2Combined sources1
Metal bindingi453Calcium 3Combined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi227 – 228NADCombined sources2
Nucleotide bindingi247 – 249NADCombined sources3
Nucleotide bindingi360 – 363ADPCombined sources4
Nucleotide bindingi361 – 363AMPCombined sources3
Nucleotide bindingi381 – 382ADPCombined sources2
Nucleotide bindingi381 – 382NADCombined sources2
Nucleotide bindingi397 – 399NADCombined sources3
Nucleotide bindingi397 – 398ADPCombined sources2
Nucleotide bindingi397 – 398AMPCombined sources2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources, NADCombined sources, Nucleotide-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciGSUL243231:GH27-570-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
TrkA domain proteinImported
Gene namesi
Ordered Locus Names:GSU0527Imported
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)Imported
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Transmembranei53 – 71HelicalSequence analysisAdd BLAST19
Transmembranei83 – 110HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU0527.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GVLX-ray3.00A/B/C/D107-564[»]
4GX0X-ray2.60A/B/C/D9-564[»]
4GX1X-ray2.80A/B/C/D9-564[»]
4GX2X-ray3.20A/B/C/D9-564[»]
4GX5X-ray3.70A/B/C/D9-564[»]
ProteinModelPortaliQ74FS9.
SMRiQ74FS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 253RCK N-terminalInterPro annotationAdd BLAST122
Domaini263 – 347RCK C-terminalInterPro annotationAdd BLAST85
Domaini353 – 471RCK N-terminalInterPro annotationAdd BLAST119
Domaini477 – 563RCK C-terminalInterPro annotationAdd BLAST87

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4107TME. Bacteria.
COG1226. LUCA.
HOGENOMiHOG000011950.
InParanoidiQ74FS9.
OMAiVITRVGR.
OrthoDBiPOG091H0517.

Family and domain databases

Gene3Di3.30.70.1450. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR013099. K_chnl_dom.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF07885. Ion_trans_2. 1 hit.
PF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
SUPFAMiSSF116726. SSF116726. 2 hits.
SSF51735. SSF51735. 2 hits.
PROSITEiPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74FS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLASELAY FLRGRARQNL KVLLLYCAFL LVMLLAYASI FRYLMWHLEG
60 70 80 90 100
REYSFMAGIY WTITVMTTLG FGDITFQSDA GYLFASIVTV SGVIFLLIIL
110 120 130 140 150
PFGFVSMFLA PWIERRLRYH PTIELPDDTR GHILIFGIDP ITRTLIRKLE
160 170 180 190 200
SRNHLFVVVT DNYDQALHLE EQEGFKVVYG SPTDAHVLAG LRVAAARSII
210 220 230 240 250
ANLSDPDNAN LCLTVRSLCQ TPIIAVVKEP VHGELLRLAG ANQVVPLTRI
260 270 280 290 300
LGRYLGIRAT TCGALAHILD SFGNLQIAEL PVHGTPFAGK TIGESGIRQR
310 320 330 340 350
TGLSIIGVWE RGSLTTPQRE TVLTEQSLLV LAGTKSQLAA LEYLIGEAPE
360 370 380 390 400
DELIFIIGHG RIGCAAAAFL DRKPVPFILI DRQESPVCND HVVVYGDATV
410 420 430 440 450
GQTLRQAGID RASGIIVTTN DDSTNIFLTL ACRHLHSHIR IVARANGEEN
460 470 480 490 500
VDQLYAAGAD FVVSNASVGA NILGNLLEHK ESAFLSEGMA VFRRPLPPAM
510 520 530 540 550
AGKTIAETRL RPLTGCSIVA IEAPDRADIL ISPPPETILA EGARLILIGT
560
SEQEKTFDQT IAAR
Length:564
Mass (Da):61,669
Last modified:July 5, 2004 - v1
Checksum:i4E56CAD82B1157D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR33858.1.
RefSeqiNP_951585.1. NC_002939.5.
WP_010941195.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR33858; AAR33858; GSU0527.
GeneIDi2687265.
KEGGigsu:GSU0527.
PATRICi22023809. VBIGeoSul17553_0528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR33858.1.
RefSeqiNP_951585.1. NC_002939.5.
WP_010941195.1. NC_002939.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GVLX-ray3.00A/B/C/D107-564[»]
4GX0X-ray2.60A/B/C/D9-564[»]
4GX1X-ray2.80A/B/C/D9-564[»]
4GX2X-ray3.20A/B/C/D9-564[»]
4GX5X-ray3.70A/B/C/D9-564[»]
ProteinModelPortaliQ74FS9.
SMRiQ74FS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243231.GSU0527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAR33858; AAR33858; GSU0527.
GeneIDi2687265.
KEGGigsu:GSU0527.
PATRICi22023809. VBIGeoSul17553_0528.

Phylogenomic databases

eggNOGiENOG4107TME. Bacteria.
COG1226. LUCA.
HOGENOMiHOG000011950.
InParanoidiQ74FS9.
OMAiVITRVGR.
OrthoDBiPOG091H0517.

Enzyme and pathway databases

BioCyciGSUL243231:GH27-570-MONOMER.

Family and domain databases

Gene3Di3.30.70.1450. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR013099. K_chnl_dom.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF07885. Ion_trans_2. 1 hit.
PF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
SUPFAMiSSF116726. SSF116726. 2 hits.
SSF51735. SSF51735. 2 hits.
PROSITEiPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ74FS9_GEOSL
AccessioniPrimary (citable) accession number: Q74FS9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.