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Protein
Submitted name:

TrkA domain protein

Gene

GSU0527

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461GlucoseCombined sources
Metal bindingi183 – 1831Calcium 1; via carbonyl oxygenCombined sources
Metal bindingi183 – 1831Calcium 2; via carbonyl oxygenCombined sources
Metal bindingi210 – 2101Calcium 1Combined sources
Metal bindingi210 – 2101Calcium 2Combined sources
Metal bindingi214 – 2141Calcium 1Combined sources
Metal bindingi214 – 2141Calcium 2Combined sources
Binding sitei249 – 2491GlucoseCombined sources
Metal bindingi359 – 3591Zinc; via tele nitrogenCombined sources
Binding sitei361 – 3611NADCombined sources
Metal bindingi364 – 3641ZincCombined sources
Binding sitei372 – 3721GlucoseCombined sources
Binding sitei381 – 3811AMPCombined sources
Metal bindingi388 – 3881ZincCombined sources
Metal bindingi391 – 3911Zinc; via pros nitrogenCombined sources
Binding sitei418 – 4181ADP; via carbonyl oxygenCombined sources
Binding sitei420 – 4201AMPCombined sources
Binding sitei420 – 4201NAD; via amide nitrogenCombined sources
Binding sitei444 – 4441ADPCombined sources
Binding sitei444 – 4441AMPCombined sources
Binding sitei444 – 4441NADCombined sources
Metal bindingi449 – 4491Calcium 2; via carbonyl oxygenCombined sources
Metal bindingi449 – 4491Calcium 3; via carbonyl oxygenCombined sources
Metal bindingi450 – 4501Calcium 2Combined sources
Metal bindingi450 – 4501Calcium 3Combined sources
Metal bindingi453 – 4531Calcium 2Combined sources
Metal bindingi453 – 4531Calcium 3Combined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi227 – 2282NADCombined sources
Nucleotide bindingi247 – 2493NADCombined sources
Nucleotide bindingi360 – 3634ADPCombined sources
Nucleotide bindingi361 – 3633AMPCombined sources
Nucleotide bindingi381 – 3822ADPCombined sources
Nucleotide bindingi381 – 3822NADCombined sources
Nucleotide bindingi397 – 3993NADCombined sources
Nucleotide bindingi397 – 3982ADPCombined sources
Nucleotide bindingi397 – 3982AMPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources, NADCombined sources, Nucleotide-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciGSUL243231:GH27-532-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
TrkA domain proteinImported
Gene namesi
Ordered Locus Names:GSU0527Imported
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)Imported
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4122HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7119HelicalSequence analysisAdd
BLAST
Transmembranei83 – 11028HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU0527.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GVLX-ray3.00A/B/C/D107-564[»]
4GX0X-ray2.60A/B/C/D9-564[»]
4GX1X-ray2.80A/B/C/D9-564[»]
4GX2X-ray3.20A/B/C/D9-564[»]
4GX5X-ray3.70A/B/C/D9-564[»]
ProteinModelPortaliQ74FS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 253122RCK N-terminalInterPro annotationAdd
BLAST
Domaini263 – 34785RCK C-terminalInterPro annotationAdd
BLAST
Domaini353 – 471119RCK N-terminalInterPro annotationAdd
BLAST
Domaini477 – 56387RCK C-terminalInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4107TME. Bacteria.
COG1226. LUCA.
HOGENOMiHOG000011950.
InParanoidiQ74FS9.
OMAiVITRVGR.
OrthoDBiEOG654P17.

Family and domain databases

Gene3Di3.30.70.1450. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR013099. K_chnl_dom.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF07885. Ion_trans_2. 1 hit.
PF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
SUPFAMiSSF116726. SSF116726. 2 hits.
SSF51735. SSF51735. 2 hits.
PROSITEiPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74FS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLASELAY FLRGRARQNL KVLLLYCAFL LVMLLAYASI FRYLMWHLEG
60 70 80 90 100
REYSFMAGIY WTITVMTTLG FGDITFQSDA GYLFASIVTV SGVIFLLIIL
110 120 130 140 150
PFGFVSMFLA PWIERRLRYH PTIELPDDTR GHILIFGIDP ITRTLIRKLE
160 170 180 190 200
SRNHLFVVVT DNYDQALHLE EQEGFKVVYG SPTDAHVLAG LRVAAARSII
210 220 230 240 250
ANLSDPDNAN LCLTVRSLCQ TPIIAVVKEP VHGELLRLAG ANQVVPLTRI
260 270 280 290 300
LGRYLGIRAT TCGALAHILD SFGNLQIAEL PVHGTPFAGK TIGESGIRQR
310 320 330 340 350
TGLSIIGVWE RGSLTTPQRE TVLTEQSLLV LAGTKSQLAA LEYLIGEAPE
360 370 380 390 400
DELIFIIGHG RIGCAAAAFL DRKPVPFILI DRQESPVCND HVVVYGDATV
410 420 430 440 450
GQTLRQAGID RASGIIVTTN DDSTNIFLTL ACRHLHSHIR IVARANGEEN
460 470 480 490 500
VDQLYAAGAD FVVSNASVGA NILGNLLEHK ESAFLSEGMA VFRRPLPPAM
510 520 530 540 550
AGKTIAETRL RPLTGCSIVA IEAPDRADIL ISPPPETILA EGARLILIGT
560
SEQEKTFDQT IAAR
Length:564
Mass (Da):61,669
Last modified:July 5, 2004 - v1
Checksum:i4E56CAD82B1157D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR33858.1.
RefSeqiNP_951585.1. NC_002939.5.
WP_010941195.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR33858; AAR33858; GSU0527.
GeneIDi2687265.
KEGGigsu:GSU0527.
PATRICi22023809. VBIGeoSul17553_0528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR33858.1.
RefSeqiNP_951585.1. NC_002939.5.
WP_010941195.1. NC_002939.5.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GVLX-ray3.00A/B/C/D107-564[»]
4GX0X-ray2.60A/B/C/D9-564[»]
4GX1X-ray2.80A/B/C/D9-564[»]
4GX2X-ray3.20A/B/C/D9-564[»]
4GX5X-ray3.70A/B/C/D9-564[»]
ProteinModelPortaliQ74FS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243231.GSU0527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAR33858; AAR33858; GSU0527.
GeneIDi2687265.
KEGGigsu:GSU0527.
PATRICi22023809. VBIGeoSul17553_0528.

Phylogenomic databases

eggNOGiENOG4107TME. Bacteria.
COG1226. LUCA.
HOGENOMiHOG000011950.
InParanoidiQ74FS9.
OMAiVITRVGR.
OrthoDBiEOG654P17.

Enzyme and pathway databases

BioCyciGSUL243231:GH27-532-MONOMER.

Family and domain databases

Gene3Di3.30.70.1450. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR013099. K_chnl_dom.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF07885. Ion_trans_2. 1 hit.
PF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
SUPFAMiSSF116726. SSF116726. 2 hits.
SSF51735. SSF51735. 2 hits.
PROSITEiPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCAImported.
  2. "Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel."
    Kong C., Zeng W., Ye S., Chen L., Sauer D.B., Lam Y., Derebe M.G., Jiang Y.
    Elife 1:e00184-e00184(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 9-564 IN COMPLEX WITH ADP; AMP; CALCIUM; GLUCOSE; NAD AND ZINC.

Entry informationi

Entry nameiQ74FS9_GEOSL
AccessioniPrimary (citable) accession number: Q74FS9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 13, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.