Methyl-accepting chemotaxis sensory transducer, class 40H, putative dimer with helix-swapped heme-binding site-containing PAS domain - Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Methyl-accepting chemotaxis sensory transducer, class 40H, putative dimer with helix-swapped heme-binding site-containing PAS domain EMBL AAR33913.1

Gene names

Name:	mcp40H-2 EMBL AAR33913.1
Ordered Locus Names:	GSU0582 EMBL AAR33913.1

Organism

Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP] EMBL AAR33913.1

Taxonomic identifier

243231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter ›

Protein attributes

Sequence length	696 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Heme PDB 3B47 Iron Metal-binding
Technical term	3D-structure PDB 3B47 Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

143

1

Iron (heme axial ligand); via tele nitrogen PDB 3B47

Binding site

139

1

Heme (covalent) PDB 3B47

Binding site

142

1

Heme (covalent) PDB 3B47

Sequences

Sequence

Length

Mass (Da)

Tools

Q74FM4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C5EBA03666598E34
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FASTA

696

75,773

        10         20         30         40         50         60 
MFRTRLAFKV LAIIGITLFL GFAALGITSI WLEYNAIMDL QTRNTRGLST LVVRDIGELM 

        70         80         90        100        110        120 
MAGDMAVIER YVADVRGKGA VLDLRIYDAA GRPAGKKQDA PDGEVQAALT SGATAEKRHK 

       130        140        150        160        170        180 
VDGRHVLSFI VPLANEVRCQ SCHEQGARFN GAMLLTTSLE EGYAGARNLT LALALVGVCS 

       190        200        210        220        230        240 
FFLLLGVMYL FFNRVIIRNI GEISRRVQEI AQGEGDLTAS VPVRSSDELG VLAEGINLLV 

       250        260        270        280        290        300 
TKLREIISGL YHQAGHIAIS ACRTIKETER LVASTHEQKD LSTSVAVASE EMAATLNDVA 

       310        320        330        340        350        360 
VNTQRAAQLS LSVDRAAHEG MATVTETAES IDRIKDSVMA TLDTMDKLQQ SSGQIGEIVG 

       370        380        390        400        410        420 
IIGDIADQTN LLALNAAIEA ARAGDSGKGF AVVANEVKVL SDRTASSTRE IGTIIRSIQA 

       430        440        450        460        470        480 
EIRAVVASIA EGKDKVEVGV ERSTTARRQL EDILRLAAES TDMINQIATA TEEQSATTGE 

       490        500        510        520        530        540 
ISEKISQVSG TAERVNGQME QTAGIFRELS ETAEQIYGTV GRFKVGTYHD TVKGLASEMR 

       550        560        570        580        590        600 
DRVVATLERA ASDRRVTLDA LFSSEYTPIP DTFPQKYRTP SDRLFDEIIS PIQEEILGRD 

       610        620        630        640        650        660 
SGMYYAICVD RRGYCPSHNL RYSRPLTGNR EADKEHNRTK RIFEDRTGLR CAGNTGSFLL 

       670        680        690 
QTYLRDTGEV MNDLSVPIVI GGRHWGAVRI GYRADD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome of Geobacter sulfurreducens: metal reduction in subsurface environments." Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W., Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J., Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M., Kolonay J.F. Fraser C.M. Science 302:1967-1969(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51573 / DSM 12127 / PCA.
[2]	"Structures and solution properties of two novel periplasmic sensor domains with c-type heme from chemotaxis proteins of Geobacter sulfurreducens: implications for signal transduction." Pokkuluri P.R., Pessanha M., Londer Y.Y., Wood S.J., Duke N.E., Wilton R., Catarino T., Salgueiro C.A., Schiffer M. J. Mol. Biol. 377:1498-1517(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 35-168 IN COMPLEX WITH HEME.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE017180 Genomic DNA. Translation: AAR33913.1.

RefSeq

NP_951640.1. NC_002939.5.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3B47	X-ray	2.00	A	35-168	[»]

ProteinModelPortal

Q74FM4.

SMR

Q74FM4. Positions 37-165.

ModBase

Search...

Protein-protein interaction databases

STRING

243231.GSU0582.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAR33913; AAR33913; GSU0582.

GeneID

2685861.

KEGG

gsu:GSU0582.

PATRIC

22023913. VBIGeoSul17553_0580.

Phylogenomic databases

HOGENOM

HOG000148080.

KO

K03406.

OMA

HIAISAC.

ProtClustDB

CLSK827927.

Enzyme and pathway databases

BioCyc

GSUL243231:GH27-558-MONOMER.

Family and domain databases

InterPro

IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]

Pfam

PF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]

SMART

SM00304. HAMP. 1 hit.
SM00283. MA. 1 hit.
[Graphical view]

PROSITE

PS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q74FM4.

Entry information

Entry name

Q74FM4_GEOSL

Accession

Primary (citable) accession number: Q74FM4

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)