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Q74FJ9

- PUR9_GEOSL

UniProt

Q74FJ9 - PUR9_GEOSL

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciGSUL243231:GH27-615-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:GSU0609
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Bifunctional purine biosynthesis protein PurHPRO_1000057897Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU0609.

Structurei

3D structure databases

ProteinModelPortaliQ74FJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
InParanoidiQ74FJ9.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74FJ9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKITRALIS VSDKTGILDF ARELAGYGVE ILSTGGTAKL LRDAGLAVKD
60 70 80 90 100
VSDFTGFPEM LDGRVKTLHP KVHGGLLGMR SNPDHVATMK AHGIEPIDLV
110 120 130 140 150
VVNLYPFEAT VAKPECTLED AIENIDIGGP TMLRSAAKNN ADVTVLVDPA
160 170 180 190 200
DYRPVLDEMK ASGGAVSRET NFCLAVKVYQ HTAAYDGAIS NWLGARTGEG
210 220 230 240 250
IAAYPDTVTL QFRKAQEMRY GENPHQGAAF YVERQVKEAS VATARQLQGK
260 270 280 290 300
ELSYNNIADT DAALECVKQF AEGPACVIVK HANPCGVAVG GTLLEAYDRA
310 320 330 340 350
YATDPESAFG GIIAFNRELD ADTARAICDR QFVEVIIAPA VSPEATEVVA
360 370 380 390 400
AKKNVRLLEC GTWPEKQQPR LDLKRVNGGI LVQDTDLDLY AELKVVTKRQ
410 420 430 440 450
PTEQEMKDLL FAWRVAKFVK SNAIVYGKGN MTIGVGAGQM SRVNSARIAA
460 470 480 490 500
IKAEHAGLEV KGAVMASDAF FPFRDGIDNA AAVGITAVIQ PGGSMRDAEV
510 520
IAAADEHGMA MVFTGMRHFR H
Length:521
Mass (Da):55,966
Last modified:July 5, 2004 - v1
Checksum:iFFB0C16E7098E0A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33940.1.
RefSeqiNP_951667.1. NC_002939.5.
WP_010941271.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR33940; AAR33940; GSU0609.
GeneIDi2685298.
KEGGigsu:GSU0609.
PATRICi22023971. VBIGeoSul17553_0608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33940.1 .
RefSeqi NP_951667.1. NC_002939.5.
WP_010941271.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q74FJ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU0609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR33940 ; AAR33940 ; GSU0609 .
GeneIDi 2685298.
KEGGi gsu:GSU0609.
PATRICi 22023971. VBIGeoSul17553_0608.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
InParanoidi Q74FJ9.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci GSUL243231:GH27-615-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiPUR9_GEOSL
AccessioniPrimary (citable) accession number: Q74FJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3