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Q74FJ9

- PUR9_GEOSL

UniProt

Q74FJ9 - PUR9_GEOSL

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciGSUL243231:GH27-615-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:GSU0609
    OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
    Taxonomic identifieri243231 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000000577: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Bifunctional purine biosynthesis protein PurHPRO_1000057897Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243231.GSU0609.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74FJ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiCGVATGP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q74FJ9-1 [UniParc]FASTAAdd to Basket

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    MAKITRALIS VSDKTGILDF ARELAGYGVE ILSTGGTAKL LRDAGLAVKD    50
    VSDFTGFPEM LDGRVKTLHP KVHGGLLGMR SNPDHVATMK AHGIEPIDLV 100
    VVNLYPFEAT VAKPECTLED AIENIDIGGP TMLRSAAKNN ADVTVLVDPA 150
    DYRPVLDEMK ASGGAVSRET NFCLAVKVYQ HTAAYDGAIS NWLGARTGEG 200
    IAAYPDTVTL QFRKAQEMRY GENPHQGAAF YVERQVKEAS VATARQLQGK 250
    ELSYNNIADT DAALECVKQF AEGPACVIVK HANPCGVAVG GTLLEAYDRA 300
    YATDPESAFG GIIAFNRELD ADTARAICDR QFVEVIIAPA VSPEATEVVA 350
    AKKNVRLLEC GTWPEKQQPR LDLKRVNGGI LVQDTDLDLY AELKVVTKRQ 400
    PTEQEMKDLL FAWRVAKFVK SNAIVYGKGN MTIGVGAGQM SRVNSARIAA 450
    IKAEHAGLEV KGAVMASDAF FPFRDGIDNA AAVGITAVIQ PGGSMRDAEV 500
    IAAADEHGMA MVFTGMRHFR H 521
    Length:521
    Mass (Da):55,966
    Last modified:July 5, 2004 - v1
    Checksum:iFFB0C16E7098E0A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR33940.1.
    RefSeqiNP_951667.1. NC_002939.5.
    WP_010941271.1. NC_002939.5.

    Genome annotation databases

    EnsemblBacteriaiAAR33940; AAR33940; GSU0609.
    GeneIDi2685298.
    KEGGigsu:GSU0609.
    PATRICi22023971. VBIGeoSul17553_0608.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR33940.1 .
    RefSeqi NP_951667.1. NC_002939.5.
    WP_010941271.1. NC_002939.5.

    3D structure databases

    ProteinModelPortali Q74FJ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243231.GSU0609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAR33940 ; AAR33940 ; GSU0609 .
    GeneIDi 2685298.
    KEGGi gsu:GSU0609.
    PATRICi 22023971. VBIGeoSul17553_0608.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi CGVATGP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci GSUL243231:GH27-615-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51573 / DSM 12127 / PCA.

    Entry informationi

    Entry nameiPUR9_GEOSL
    AccessioniPrimary (citable) accession number: Q74FJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3