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Q74FJ9

- PUR9_GEOSL

UniProt

Q74FJ9 - PUR9_GEOSL

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, GSU0609
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciGSUL243231:GH27-615-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:GSU0609
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000057897Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU0609.

Structurei

3D structure databases

ProteinModelPortaliQ74FJ9.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74FJ9-1 [UniParc]FASTAAdd to Basket

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MAKITRALIS VSDKTGILDF ARELAGYGVE ILSTGGTAKL LRDAGLAVKD    50
VSDFTGFPEM LDGRVKTLHP KVHGGLLGMR SNPDHVATMK AHGIEPIDLV 100
VVNLYPFEAT VAKPECTLED AIENIDIGGP TMLRSAAKNN ADVTVLVDPA 150
DYRPVLDEMK ASGGAVSRET NFCLAVKVYQ HTAAYDGAIS NWLGARTGEG 200
IAAYPDTVTL QFRKAQEMRY GENPHQGAAF YVERQVKEAS VATARQLQGK 250
ELSYNNIADT DAALECVKQF AEGPACVIVK HANPCGVAVG GTLLEAYDRA 300
YATDPESAFG GIIAFNRELD ADTARAICDR QFVEVIIAPA VSPEATEVVA 350
AKKNVRLLEC GTWPEKQQPR LDLKRVNGGI LVQDTDLDLY AELKVVTKRQ 400
PTEQEMKDLL FAWRVAKFVK SNAIVYGKGN MTIGVGAGQM SRVNSARIAA 450
IKAEHAGLEV KGAVMASDAF FPFRDGIDNA AAVGITAVIQ PGGSMRDAEV 500
IAAADEHGMA MVFTGMRHFR H 521
Length:521
Mass (Da):55,966
Last modified:July 5, 2004 - v1
Checksum:iFFB0C16E7098E0A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33940.1.
RefSeqiNP_951667.1. NC_002939.5.
WP_010941271.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR33940; AAR33940; GSU0609.
GeneIDi2685298.
KEGGigsu:GSU0609.
PATRICi22023971. VBIGeoSul17553_0608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR33940.1 .
RefSeqi NP_951667.1. NC_002939.5.
WP_010941271.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q74FJ9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243231.GSU0609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR33940 ; AAR33940 ; GSU0609 .
GeneIDi 2685298.
KEGGi gsu:GSU0609.
PATRICi 22023971. VBIGeoSul17553_0608.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci GSUL243231:GH27-615-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiPUR9_GEOSL
AccessioniPrimary (citable) accession number: Q74FJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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