ID   Q74ED3_GEOSL            Unreviewed;       549 AA.
AC   Q74ED3;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Methyl-accepting chemotaxis sensory transducer, class 40H {ECO:0000313|EMBL:AAR34356.1};
GN   Name=mcp40H-4 {ECO:0000313|EMBL:AAR34356.1};
GN   OrderedLocusNames=GSU1029 {ECO:0000313|EMBL:AAR34356.1};
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231 {ECO:0000313|EMBL:AAR34356.1, ECO:0000313|Proteomes:UP000000577};
RN   [1] {ECO:0000313|EMBL:AAR34356.1, ECO:0000313|Proteomes:UP000000577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA
RC   {ECO:0000313|Proteomes:UP000000577};
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.,
RA   Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M.,
RA   Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.,
RA   Khouri H., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R.,
RA   Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AE017180; AAR34356.1; -; Genomic_DNA.
DR   RefSeq; NP_952083.1; NC_002939.5.
DR   RefSeq; WP_010941692.1; NC_002939.5.
DR   AlphaFoldDB; Q74ED3; -.
DR   SMR; Q74ED3; -.
DR   STRING; 243231.GSU1029; -.
DR   EnsemblBacteria; AAR34356; AAR34356; GSU1029.
DR   KEGG; gsu:GSU1029; -.
DR   PATRIC; fig|243231.5.peg.1029; -.
DR   eggNOG; COG0840; Bacteria.
DR   HOGENOM; CLU_000445_107_27_7; -.
DR   InParanoid; Q74ED3; -.
DR   OrthoDB; 9791237at2; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd11386; MCP_signal; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR024478; HlyB_4HB_MCP.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR32089:SF112; HEME-BASED AEROTACTIC TRANSDUCER HEMAT; 1.
DR   PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR   Pfam; PF12729; 4HB_MCP_1; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000577};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00284}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        194..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          219..271
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          276..512
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
SQ   SEQUENCE   549 AA;  58109 MW;  D9811E04A6D58F2D CRC64;
     MSAWRDLKVR TKIFVLVIAG CLGLVVLGSV ALYNMRNLSG SVKEANIGME HVAGLSGMKS
     DFLEMRLALV YMLALKDAEK IGGKEQDFLK AADRIKKTLD DLGKQELTDT EKKSLVEFRG
     GFESYVEKGT RLAELIKDAT AKGDEVGRAD AMTFATQSVA PLYDTPAKII ASMVQENIGE
     AHKMYEQDMA SYRASFIMMV VIILGVIGVA AAAGLAIAGS ISGPLNKVLD VLTRVAAGDL
     TARADVVSAD EMGLLAREVN TTAAKINEII GLVAHNASQV TAAATQLHAT STQMSTGAEE
     VAQQAATVAT ASEEMAATSA EIAHNCSLAA ESSRHANDRA ENGSDVVQET LTVMNRIAER
     VKDSARTVES LGERSDQIGE IIGTIQDIAD QTNLLALNAA IEAARAGEQG RGFAVVADEV
     RALAERTTKA TKEISQMIKA IQGETKGAVT SMEEGVKEVE KGTSDASKSG EALQAILEQI
     GGVTMQVSQI ATAAEEQTAT TGEINNNIQQ ITEVVQLTAR GAEESAQAAE QLAKLAEELQ
     DLVYKFKLA
//