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Q74E52

- MTAP_GEOSL

UniProt

Q74E52 - MTAP_GEOSL

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
mtnP, GSU1112
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Phosphate By similarity
Sitei167 – 1671Important for substrate specificity By similarity
Binding sitei185 – 1851Substrate; via amide nitrogen By similarity
Binding sitei186 – 1861Phosphate By similarity
Sitei222 – 2221Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciGSUL243231:GH27-1119-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Gene namesi
Name:mtnP
Ordered Locus Names:GSU1112
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000415092Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU1112.

Structurei

3D structure databases

ProteinModelPortaliQ74E52.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Phosphate binding By similarity
Regioni86 – 872Phosphate binding By similarity
Regioni209 – 2113Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228986.
KOiK00772.
OMAiISTTACG.
OrthoDBiEOG6KHFXC.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74E52-1 [UniParc]FASTAAdd to Basket

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MEQVIGVIGG SGLYEMEGLQ DVRSIVVETP FGAPSDEFVT GVLDGVRMVF    50
LPRHGRGHRL LPTEVNYRAN IYGMKKLGVT RIISVSAVGS MREEIVPGHI 100
VIPDQFIDRT NATRANTFFG NGVVAHIQFA DPVCADLSAD LYAAAQEAGA 150
TVHRGGTYIC MEGPAFSTRA ESNLYRSFGV SVIGMTNIPE AKLAREAEIC 200
YGVIALATDY DCWHESHDDV SVDAIIAIIK QNVAMAKSII RNAVRRIDRE 250
RNCPCASALR YAIITDKAAI PAETKERLDL IIGSYV 286
Length:286
Mass (Da):31,105
Last modified:July 5, 2004 - v1
Checksum:i4F7F8EADF7018E50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR34438.1.
RefSeqiNP_952165.1. NC_002939.5.
WP_010941773.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR34438; AAR34438; GSU1112.
GeneIDi2688551.
KEGGigsu:GSU1112.
PATRICi22024986. VBIGeoSul17553_1108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR34438.1 .
RefSeqi NP_952165.1. NC_002939.5.
WP_010941773.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q74E52.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243231.GSU1112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR34438 ; AAR34438 ; GSU1112 .
GeneIDi 2688551.
KEGGi gsu:GSU1112.
PATRICi 22024986. VBIGeoSul17553_1108.

Phylogenomic databases

HOGENOMi HOG000228986.
KOi K00772.
OMAi ISTTACG.
OrthoDBi EOG6KHFXC.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci GSUL243231:GH27-1119-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiMTAP_GEOSL
AccessioniPrimary (citable) accession number: Q74E52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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