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Q74E52

- MTAP_GEOSL

UniProt

Q74E52 - MTAP_GEOSL

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111PhosphateUniRule annotation
Sitei167 – 1671Important for substrate specificityUniRule annotation
Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation
Binding sitei186 – 1861PhosphateUniRule annotation
Sitei222 – 2221Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciGSUL243231:GH27-1119-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:GSU1112
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286S-methyl-5'-thioadenosine phosphorylasePRO_0000415092Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU1112.

Structurei

3D structure databases

ProteinModelPortaliQ74E52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Phosphate bindingUniRule annotation
Regioni86 – 872Phosphate bindingUniRule annotation
Regioni209 – 2113Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228986.
InParanoidiQ74E52.
KOiK00772.
OMAiISTTACG.
OrthoDBiEOG6KHFXC.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74E52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQVIGVIGG SGLYEMEGLQ DVRSIVVETP FGAPSDEFVT GVLDGVRMVF
60 70 80 90 100
LPRHGRGHRL LPTEVNYRAN IYGMKKLGVT RIISVSAVGS MREEIVPGHI
110 120 130 140 150
VIPDQFIDRT NATRANTFFG NGVVAHIQFA DPVCADLSAD LYAAAQEAGA
160 170 180 190 200
TVHRGGTYIC MEGPAFSTRA ESNLYRSFGV SVIGMTNIPE AKLAREAEIC
210 220 230 240 250
YGVIALATDY DCWHESHDDV SVDAIIAIIK QNVAMAKSII RNAVRRIDRE
260 270 280
RNCPCASALR YAIITDKAAI PAETKERLDL IIGSYV
Length:286
Mass (Da):31,105
Last modified:July 5, 2004 - v1
Checksum:i4F7F8EADF7018E50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR34438.1.
RefSeqiNP_952165.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR34438; AAR34438; GSU1112.
GeneIDi2688551.
KEGGigsu:GSU1112.
PATRICi22024986. VBIGeoSul17553_1108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR34438.1 .
RefSeqi NP_952165.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q74E52.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU1112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR34438 ; AAR34438 ; GSU1112 .
GeneIDi 2688551.
KEGGi gsu:GSU1112.
PATRICi 22024986. VBIGeoSul17553_1108.

Phylogenomic databases

HOGENOMi HOG000228986.
InParanoidi Q74E52.
KOi K00772.
OMAi ISTTACG.
OrthoDBi EOG6KHFXC.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci GSUL243231:GH27-1119-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiMTAP_GEOSL
AccessioniPrimary (citable) accession number: Q74E52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3