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Q74E52 (MTAP_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
S-methyl-5'-thioadenosine phosphorylase

EC=2.4.2.28
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name=MTA phosphorylase
Short name=MTAP
Gene names
Name:mtnP
Ordered Locus Names:GSU1112
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity. HAMAP-Rule MF_01963

Catalytic activity

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01963

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. HAMAP-Rule MF_01963

Subunit structure

Homohexamer. Dimer of a homotrimer By similarity. HAMAP-Rule MF_01963

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286S-methyl-5'-thioadenosine phosphorylase HAMAP-Rule MF_01963
PRO_0000415092

Regions

Region53 – 542Phosphate binding By similarity
Region86 – 872Phosphate binding By similarity
Region209 – 2113Substrate binding By similarity

Sites

Binding site111Phosphate By similarity
Binding site1851Substrate; via amide nitrogen By similarity
Binding site1861Phosphate By similarity
Site1671Important for substrate specificity By similarity
Site2221Important for substrate specificity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q74E52 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4F7F8EADF7018E50

FASTA28631,105
        10         20         30         40         50         60 
MEQVIGVIGG SGLYEMEGLQ DVRSIVVETP FGAPSDEFVT GVLDGVRMVF LPRHGRGHRL 

        70         80         90        100        110        120 
LPTEVNYRAN IYGMKKLGVT RIISVSAVGS MREEIVPGHI VIPDQFIDRT NATRANTFFG 

       130        140        150        160        170        180 
NGVVAHIQFA DPVCADLSAD LYAAAQEAGA TVHRGGTYIC MEGPAFSTRA ESNLYRSFGV 

       190        200        210        220        230        240 
SVIGMTNIPE AKLAREAEIC YGVIALATDY DCWHESHDDV SVDAIIAIIK QNVAMAKSII 

       250        260        270        280 
RNAVRRIDRE RNCPCASALR YAIITDKAAI PAETKERLDL IIGSYV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017180 Genomic DNA. Translation: AAR34438.1.
RefSeqNP_952165.1. NC_002939.5.

3D structure databases

ProteinModelPortalQ74E52.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243231.GSU1112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR34438; AAR34438; GSU1112.
GeneID2688551.
KEGGgsu:GSU1112.
PATRIC22024986. VBIGeoSul17553_1108.

Phylogenomic databases

HOGENOMHOG000228986.
KOK00772.
OMAMTNHTEA.
OrthoDBEOG6KHFXC.
ProtClustDBCLSK828184.

Enzyme and pathway databases

BioCycGSUL243231:GH27-1119-MONOMER.
UniPathwayUPA00904; UER00873.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
HAMAPMF_01963. MTAP.
InterProIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01694. MTAP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTAP_GEOSL
AccessionPrimary (citable) accession number: Q74E52
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways