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Q74E52

- MTAP_GEOSL

UniProt

Q74E52 - MTAP_GEOSL

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111PhosphateUniRule annotation
    Sitei167 – 1671Important for substrate specificityUniRule annotation
    Binding sitei185 – 1851Substrate; via amide nitrogenUniRule annotation
    Binding sitei186 – 1861PhosphateUniRule annotation
    Sitei222 – 2221Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciGSUL243231:GH27-1119-MONOMER.
    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Gene namesi
    Name:mtnPUniRule annotation
    Ordered Locus Names:GSU1112
    OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
    Taxonomic identifieri243231 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000000577: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286S-methyl-5'-thioadenosine phosphorylasePRO_0000415092Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. Dimer of a homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243231.GSU1112.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74E52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni53 – 542Phosphate bindingUniRule annotation
    Regioni86 – 872Phosphate bindingUniRule annotation
    Regioni209 – 2113Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000228986.
    KOiK00772.
    OMAiISTTACG.
    OrthoDBiEOG6KHFXC.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q74E52-1 [UniParc]FASTAAdd to Basket

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    MEQVIGVIGG SGLYEMEGLQ DVRSIVVETP FGAPSDEFVT GVLDGVRMVF    50
    LPRHGRGHRL LPTEVNYRAN IYGMKKLGVT RIISVSAVGS MREEIVPGHI 100
    VIPDQFIDRT NATRANTFFG NGVVAHIQFA DPVCADLSAD LYAAAQEAGA 150
    TVHRGGTYIC MEGPAFSTRA ESNLYRSFGV SVIGMTNIPE AKLAREAEIC 200
    YGVIALATDY DCWHESHDDV SVDAIIAIIK QNVAMAKSII RNAVRRIDRE 250
    RNCPCASALR YAIITDKAAI PAETKERLDL IIGSYV 286
    Length:286
    Mass (Da):31,105
    Last modified:July 5, 2004 - v1
    Checksum:i4F7F8EADF7018E50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR34438.1.
    RefSeqiNP_952165.1. NC_002939.5.
    WP_010941773.1. NC_002939.5.

    Genome annotation databases

    EnsemblBacteriaiAAR34438; AAR34438; GSU1112.
    GeneIDi2688551.
    KEGGigsu:GSU1112.
    PATRICi22024986. VBIGeoSul17553_1108.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR34438.1 .
    RefSeqi NP_952165.1. NC_002939.5.
    WP_010941773.1. NC_002939.5.

    3D structure databases

    ProteinModelPortali Q74E52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243231.GSU1112.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAR34438 ; AAR34438 ; GSU1112 .
    GeneIDi 2688551.
    KEGGi gsu:GSU1112.
    PATRICi 22024986. VBIGeoSul17553_1108.

    Phylogenomic databases

    HOGENOMi HOG000228986.
    KOi K00772.
    OMAi ISTTACG.
    OrthoDBi EOG6KHFXC.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .
    BioCyci GSUL243231:GH27-1119-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51573 / DSM 12127 / PCA.

    Entry informationi

    Entry nameiMTAP_GEOSL
    AccessioniPrimary (citable) accession number: Q74E52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3