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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-1597-MONOMER
UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotation (EC:2.1.3.15UniRule annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
Ordered Locus Names:GSU1402
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002237721 – 319Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaAdd BLAST319

Proteomic databases

PRIDEiQ74DB5

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU1402

Structurei

3D structure databases

SMRiQ74DB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 293CoA carboxyltransferase C-terminalPROSITE-ProRule annotationAdd BLAST255

Sequence similaritiesi

Belongs to the AccA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QM9 Bacteria
COG0825 LUCA
HOGENOMiHOG000273832
InParanoidiQ74DB5
KOiK01962
OrthoDBiPOG091H0647

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q74DB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQYYMEFE KPVVELEKKV QELAELAGTN AELAGEVTKL EKKVDRMREV
60 70 80 90 100
IFSNLSRWQT VQVARHIERP FTLDYLNLIF TDFTELHGDR LFGDDHAIVA
110 120 130 140 150
GLAKLDGEPV VVIGHQKGRD TKEKVYRNFG MPNPEGYRKA LRIMELAERF
160 170 180 190 200
RLPIITFVDT PGAFPGIGAE ERGQAEAIAR NLREMAALTV PIIVVVTGEG
210 220 230 240 250
GSGGALAIAV GDRVLMLQYS IYAVISPEGC AAILWSDGTK GEQAAEALKL
260 270 280 290 300
TAKDLKELEV IDEIVPEPLG GAHRDHEAMA RTLHEAIARQ LKELKAIPAE
310
QLVEERYQKF RKMSRFIEG
Length:319
Mass (Da):35,524
Last modified:May 29, 2013 - v2
Checksum:i9863AD699C5F2A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR34777.2
RefSeqiNP_952454.4, NC_002939.5
WP_010942051.1, NC_002939.5

Genome annotation databases

EnsemblBacteriaiAAR34777; AAR34777; GSU1402
GeneIDi2687857
KEGGigsu:GSU1402
PATRICifig|243231.5.peg.1449

Similar proteinsi

Entry informationi

Entry nameiACCA_GEOSL
AccessioniPrimary (citable) accession number: Q74DB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: May 29, 2013
Last modified: May 23, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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