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Q74CS9

- PNP_GEOSL

UniProt

Q74CS9 - PNP_GEOSL

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi484 – 4841MagnesiumUniRule annotation
Metal bindingi490 – 4901MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:GSU1593
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Polyribonucleotide nucleotidyltransferasePRO_0000329662Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU1593.

Structurei

3D structure databases

ProteinModelPortaliQ74CS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini551 – 61060KHUniRule annotationAdd
BLAST
Domaini620 – 68869S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
InParanoidiQ74CS9.
KOiK00962.
OMAiHGNFKSN.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74CS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEHKVNVEF GGRTITIATG KWAKQASGAV VVSCGDTVVL VTAVATKSAR
60 70 80 90 100
EGQDFFPLTV NYQEKAYAGG KIPGGFFKRE GRPSDNETLT SRFIDRPIRP
110 120 130 140 150
LFPESFLNDT QIMATVVSAD QDNDPGILAM IGASAALEVS DIPFLGPIAG
160 170 180 190 200
VKVGRVDGQF VCNPTVEQLE KSDLEIVVAA SRDAVIMVEG GAAEASEKDV
210 220 230 240 250
LEAIFFGHAA VQPIIEAQTD LRKLAGVPKR EVAATSVDEA LKTRVKDLAY
260 270 280 290 300
AGIKEAVRIV AKQERHNRIG EITAQTLETL LPEYEGRESE IKGFLGDFEY
310 320 330 340 350
ELVREHIIKD GYRIDGRDTT TIRPISIEVS MLPRAHGSAL FTRGETQALV
360 370 380 390 400
ASTLGTSIDE QRIDSLYGET RKRFLLHYNF PPFSVGETSF RLAPGRREIG
410 420 430 440 450
HGMLAERALE RVVPKHEDFP YTIRIVSDIL ESNGSSSMAT VCGGALAMMD
460 470 480 490 500
AGVPIKAPVA GIAMGLIKEG EGIAILSDIL GDEDHLGDMD FKVAGTEAGV
510 520 530 540 550
TAIQMDIKIT GVTREIMEKA LLQARDGRLH ILGKMNQAIA APRTDLSPYA
560 570 580 590 600
PRITTIWVKT DKIRDVIGSG GKNIRGITEA TGVSIDIEDS GRINIASTSK
610 620 630 640 650
EACDKAIKMI RDLTAEAEEG KLYMGTVKKV MDFGAFVEIF PGTDGLVHIS
660 670 680 690
ELDTERVKNV TDVLNEGDKV LVKCIGIDKQ GKIKLSRKEA LGAVLPE
Length:697
Mass (Da):75,348
Last modified:July 5, 2004 - v1
Checksum:i23D722D1F0335F12
GO

Sequence cautioni

The sequence AAR34967.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR34967.2. Different initiation.
RefSeqiNP_952644.4. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR34967; AAR34967; GSU1593.
GeneIDi2687125.
KEGGigsu:GSU1593.
PATRICi22026031. VBIGeoSul17553_1634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR34967.2 . Different initiation.
RefSeqi NP_952644.4. NC_002939.5.

3D structure databases

ProteinModelPortali Q74CS9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU1593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR34967 ; AAR34967 ; GSU1593 .
GeneIDi 2687125.
KEGGi gsu:GSU1593.
PATRICi 22026031. VBIGeoSul17553_1634.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
InParanoidi Q74CS9.
KOi K00962.
OMAi HGNFKSN.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiPNP_GEOSL
AccessioniPrimary (citable) accession number: Q74CS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3