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Q74CS1 (Q74CS1_GEOSL) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabH-2 EMBL AAR34975.1
Synonyms:fabH2 HAMAP MF_01815
Ordered Locus Names:GSU1601
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. SAAS SAAS013747 HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q74CS1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: D676863EDBB47A66

FASTA32534,852
        10         20         30         40         50         60 
MRARIVGTGS AVPSKVLTNF DLEKMVDTSD EWVTTRTGIK ERRIAVDGEY TSTFATLAAE 

        70         80         90        100        110        120 
RALEMAGVKA SDLDLLIVAT ITPDFPFPAT ACVVQSNLKA TKAAAYDISA ACSGFIYALA 

       130        140        150        160        170        180 
QASNAIRSGS ARKALVIGAE VLSRIIDWTD RNTCLLFGDG AGAVVLEACD DGHGVLSTHL 

       190        200        210        220        230        240 
HSDGSYWELL YQPGCGNRNP AVQKTLDDRR IYLMMQGNEV FKLAVRAMED AALEALDANG 

       250        260        270        280        290        300 
LTPADISLFI PHQANRRIID AIGKRLGLPG EKVYVNLDRF GNTSAASIPL ALDEANRSGR 

       310        320 
IKPNDVVVFD AFGGGLTWGS ALVRW

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017180 Genomic DNA. Translation: AAR34975.1.
RefSeqNP_952652.1. NC_002939.4.

3D structure databases

ProteinModelPortalQ74CS1.
SMRQ74CS1. Positions 1-325.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2685435.
GenomeReviewsGene locus GSU1601 in contig AE017180_GR.
KEGGgsu:GSU1601.
NMPDRfig|243231.1.peg.1590.
PATRIC22026049. VBIGeoSul17553_1643.
TIGRGSU1601.

Phylogenomic databases

HOGENOMHBG649927.
OMAFNAKEEA.
PhylomeDBQ74CS1.
ProtClustDBCLSK828432.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ74CS1_GEOSL
AccessionPrimary (citable) accession number: Q74CS1
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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