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Q74CG7

- PANC_GEOSL

UniProt

Q74CG7 - PANC_GEOSL

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Protein

Pantothenate synthetase

Gene

panC

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donorUniRule annotation
Binding sitei61 – 611Beta-alanineUniRule annotation
Binding sitei61 – 611PantoateUniRule annotation
Binding sitei153 – 1531PantoateUniRule annotation
Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPUniRule annotation
Nucleotide bindingi147 – 1504ATPUniRule annotation
Nucleotide bindingi184 – 1874ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSUL243231:GH27-1723-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:GSU1706
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Pantothenate synthetasePRO_0000128233Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU1706.

Structurei

3D structure databases

ProteinModelPortaliQ74CG7.
SMRiQ74CG7. Positions 1-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiQ74CG7.
KOiK01918.
OMAiRRYWRES.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74CG7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIIDSVADM QAFSRDARRS GKTIALVPTM GYLHDGHASL MREGRTRADI
60 70 80 90 100
LVVSIFVNPT QFGPNEDFTT YPRDLERDLQ VAEAAGADVI FAPRADDMYP
110 120 130 140 150
AGFQTYVDVE KVTLPLCGAS RPGHFRGVTT VVAKLFNIVM PHTAFFGKKD
160 170 180 190 200
FQQLAVIRRM VADLNMDLSI VGMPIIREPD GLAMSSRNAY LGPQERTNAL
210 220 230 240 250
CLNRSLAAAR TLFTDGERSV ARLRDTVLRI LTEVPGAAID YADFRDSETL
260 270 280
EPVEAANEKT LLALAVKIGT TRLIDNCVLG EEQ
Length:283
Mass (Da):31,164
Last modified:July 5, 2004 - v1
Checksum:iBD46D903751A519F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR35084.1.
RefSeqiNP_952757.1. NC_002939.5.
WP_010942350.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR35084; AAR35084; GSU1706.
GeneIDi2685348.
KEGGigsu:GSU1706.
PATRICi22026267. VBIGeoSul17553_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR35084.1 .
RefSeqi NP_952757.1. NC_002939.5.
WP_010942350.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q74CG7.
SMRi Q74CG7. Positions 1-280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU1706.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR35084 ; AAR35084 ; GSU1706 .
GeneIDi 2685348.
KEGGi gsu:GSU1706.
PATRICi 22026267. VBIGeoSul17553_1751.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
InParanoidi Q74CG7.
KOi K01918.
OMAi RRYWRES.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci GSUL243231:GH27-1723-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiPANC_GEOSL
AccessioniPrimary (citable) accession number: Q74CG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3