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Q74CB6

- PUR5_GEOSL

UniProt

Q74CB6 - PUR5_GEOSL

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSUL243231:GH27-1776-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:GSU1758
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258358Add
BLAST

Proteomic databases

PRIDEiQ74CB6.

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU1758.

Structurei

3D structure databases

ProteinModelPortaliQ74CB6.
SMRiQ74CB6. Positions 6-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
InParanoidiQ74CB6.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74CB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKRGFTYKD AGVDIDAGNT FVGLIKPFVK ATSRPEVISD IGGFGGLFSL
60 70 80 90 100
NTNKYRNPVL VSGTDGVGTK LKIAMMADRH DTVGIDLVAM CVNDIIVQGA
110 120 130 140 150
EPLFFLDYFA TGKLDPQRGA AVVKGISEGC VQAGCALIGG ETAEMPGFYQ
160 170 180 190 200
PGEYDLAGFT VGVVERDNII DGSSITVGNR LVGIASSGLH SNGYSLARKI
210 220 230 240 250
IFESMGLGID SILPGLGMSA ADALLTPTKI YVKTILNLLR DFHVNGIAHI
260 270 280 290 300
TGGGLLENVP RVLPNGCKAL VHLDSCPLPP LFSLLQEAGS VERDEMYRTF
310 320 330 340
NCGIGMVLAV PENEADEILI RLSGLQEKAF IIGEIAKCEP GAEMVELV
Length:348
Mass (Da):36,841
Last modified:July 5, 2004 - v1
Checksum:iACA3088D52A5C6DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR35135.1.
RefSeqiNP_952808.1. NC_002939.5.
WP_010942402.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR35135; AAR35135; GSU1758.
GeneIDi2687407.
KEGGigsu:GSU1758.
PATRICi22026361. VBIGeoSul17553_1798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR35135.1 .
RefSeqi NP_952808.1. NC_002939.5.
WP_010942402.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q74CB6.
SMRi Q74CB6. Positions 6-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU1758.

Proteomic databases

PRIDEi Q74CB6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR35135 ; AAR35135 ; GSU1758 .
GeneIDi 2687407.
KEGGi gsu:GSU1758.
PATRICi 22026361. VBIGeoSul17553_1798.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
InParanoidi Q74CB6.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci GSUL243231:GH27-1776-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiPUR5_GEOSL
AccessioniPrimary (citable) accession number: Q74CB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3