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Q74CB0 (DXS2_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase 2
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 2
Short name=DXP synthase 2
Short name=DXPS 2
Gene names
Name:dxs2
Ordered Locus Names:GSU1764
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6266261-deoxy-D-xylulose-5-phosphate synthase 2 HAMAP MF_00315
PRO_0000256425

Sequences

Sequence LengthMass (Da)Tools
Q74CB0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 581B4940BE8F9186

FASTA62666,831
        10         20         30         40         50         60 
MSRILDRVDS PSDLKGLTTA ELGILAEEIR QEIITVCSRN GGHLAPSLGV VELTLALHRV 

        70         80         90        100        110        120 
FTSPEDKIVW DVGHQAYAHK LVTGRRDRFA TLRTLGGISG FLKRAESPHD VFDAGHASTS 

       130        140        150        160        170        180 
ISAALGLAAA RDLAGRNNKV VAVIGDGSMT GGIAYEGLNH AGHLNRDLVV VLNDNEMSIA 

       190        200        210        220        230        240 
ENVGALSNFL SRTVTSEFVH TLKKDVETFL GGLDRIGRNV LKVAKRAEES LKGLFTPGML 

       250        260        270        280        290        300 
FEAFGFEYIG PIDGHDIGRL TETFEKVKRF DDAVLIHVLT KKGKGFAPAE AKPSLFHGVG 

       310        320        330        340        350        360 
PFDPVSGEIV KGKGGATSYT GVFGQALTRI ADEDERVVAI TAAMPDGTGL GSFSARHPGR 

       370        380        390        400        410        420 
FFDVGIAEQH GVTFAAGLAA EGYRPVFAIY SSFLQRAYDQ LFHDVCLMNL PVTFAIDRSG 

       430        440        450        460        470        480 
VVGSDGPTHH GLFDLSYLRT LPNMVVMAPK DENELQHMLK TAIDHNGPAA VRYPRGNGLG 

       490        500        510        520        530        540 
VPLDQSLAPI PLGTSEVLRA GSGTCVVLAV GAMVGPALEA ANTLEGEGID LTVVNVRFVK 

       550        560        570        580        590        600 
PLDRELILSY VGRAGTLVTI EENVLQGGFG SAVLELLADE GVGGVAVHRF GYPDRYVEQG 

       610        620 
EQHELRSRYG LDAEGIAGRI RTLSAR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017180 Genomic DNA. Translation: AAR35141.1.
RefSeqNP_952814.1. NC_002939.4.

3D structure databases

ProteinModelPortalQ74CB0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2686761.
GenomeReviewsGene locus GSU1764 in contig AE017180_GR.
KEGGgsu:GSU1764.
NMPDRfig|243231.1.peg.1752.
PATRIC22026371. VBIGeoSul17553_1803.
TIGRGSU1764.

Phylogenomic databases

HOGENOMHBG571647.
OMACTIYSSF.
PhylomeDBQ74CB0.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycGSUL243231:GSU_1764-MONOMER.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS2_GEOSL
AccessionPrimary (citable) accession number: Q74CB0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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