Q74C63 (SYR_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	GSU1812

Organism

Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]

Taxonomic identifier

243231 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter › Geobacter sulfurreducens

Protein attributes

Sequence length	561 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subunit structure	Monomer By similarity. HAMAP-Rule MF_00123
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.
Sequence caution	The sequence AAR35189.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 561	561	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_0000242027
Regions
	Motif	129 – 139	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q74C63 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: B830F363271BBAB9	FASTA	561	62,308
	10 20 30 40 50 60 MKDAVRDLVR EALERSFADG TLASGHVPDI VVEKPALEEH GDFACTAAML MAKAEKKAPR 70 80 90 100 110 120 AIAEIIITHL NDRESLVESV EIAGPGFINF RMRTSAWCRV LRRIEREGGD YGKSEAGAGK 130 140 150 160 170 180 KVQVEFVSAN PTGPLHIGHG RGAAIGDTIC RLLAAIGWDV TREFYYNDAG QQIANLALSV 190 200 210 220 230 240 QARCLGVEPG GPLWPTDGYQ GEYIKDVARS YLNRETVDAG DQHVTAAGDP HDVEAIRRFA 250 260 270 280 290 300 VAYLRREQDQ DLRAFDVGFD VYFLESSLYA EGRVDDVVQR IIAKGHAYEQ DGALWLRTTE 310 320 330 340 350 360 FGDDKDRVMR KSDGSYTYFV PDVAYHLNKW ERGFIRVVNE QGADHHSTIT RVRAGLQALD 370 380 390 400 410 420 AGIPKGWPEY VLHQMVTVMR GGEEVKISKR AGSYVTLRDL VDEVGRDATR FFFLMRKPDS 430 440 450 460 470 480 QLVFDIDLAK QQTLENPVYY VQYAHARICS IFENAADKGV VPPTVDQASL ESLGTPEELT 490 500 510 520 530 540 LVKLLSSFPE IVEGSALNFE PHRITYYLQE LAGAFHSFYN KNRVITEDAD LTGARLLLLH 550 560 STATVIRNGL GLLGVSAPEK M

References

[1]

"Genome of Geobacter sulfurreducens: metal reduction in subsurface environments." Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C., Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J., Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.L., Kolonay J.F. , Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R., Fraser C.M. Science 302:1967-1969(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51573 / DSM 12127 / PCA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017180 Genomic DNA. Translation: AAR35189.1. Different initiation.
RefSeq	NP_952862.1. NC_002939.5.
3D structure databases
ProteinModelPortal	Q74C63.
ModBase	Search...
Protein-protein interaction databases
STRING	243231.GSU1812.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAR35189; AAR35189; GSU1812.
GeneID	2686712.
KEGG	gsu:GSU1812.
PATRIC	22026481. VBIGeoSul17553_1849.
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247214.
KO	K01887.
OMA	HTSANPN.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	GSUL243231:GH27-1839-MONOMER.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 1 hit.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_GEOSL

Accession

Primary (citable) accession number: Q74C63

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 29, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program