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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:GSU1812
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002420271 – 561Arginine--tRNA ligaseAdd BLAST561

Proteomic databases

PRIDEiQ74C63

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU1812

Structurei

3D structure databases

ProteinModelPortaliQ74C63
SMRiQ74C63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 139"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247214
InParanoidiQ74C63
KOiK01887
OMAiNKPLHLG
OrthoDBiPOG091H01RF

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q74C63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDAVRDLVR EALERSFADG TLASGHVPDI VVEKPALEEH GDFACTAAML
60 70 80 90 100
MAKAEKKAPR AIAEIIITHL NDRESLVESV EIAGPGFINF RMRTSAWCRV
110 120 130 140 150
LRRIEREGGD YGKSEAGAGK KVQVEFVSAN PTGPLHIGHG RGAAIGDTIC
160 170 180 190 200
RLLAAIGWDV TREFYYNDAG QQIANLALSV QARCLGVEPG GPLWPTDGYQ
210 220 230 240 250
GEYIKDVARS YLNRETVDAG DQHVTAAGDP HDVEAIRRFA VAYLRREQDQ
260 270 280 290 300
DLRAFDVGFD VYFLESSLYA EGRVDDVVQR IIAKGHAYEQ DGALWLRTTE
310 320 330 340 350
FGDDKDRVMR KSDGSYTYFV PDVAYHLNKW ERGFIRVVNE QGADHHSTIT
360 370 380 390 400
RVRAGLQALD AGIPKGWPEY VLHQMVTVMR GGEEVKISKR AGSYVTLRDL
410 420 430 440 450
VDEVGRDATR FFFLMRKPDS QLVFDIDLAK QQTLENPVYY VQYAHARICS
460 470 480 490 500
IFENAADKGV VPPTVDQASL ESLGTPEELT LVKLLSSFPE IVEGSALNFE
510 520 530 540 550
PHRITYYLQE LAGAFHSFYN KNRVITEDAD LTGARLLLLH STATVIRNGL
560
GLLGVSAPEK M
Length:561
Mass (Da):62,308
Last modified:June 27, 2006 - v2
Checksum:iB830F363271BBAB9
GO

Sequence cautioni

The sequence AAR35189 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR35189.1 Different initiation.
RefSeqiNP_952862.1, NC_002939.5

Genome annotation databases

EnsemblBacteriaiAAR35189; AAR35189; GSU1812
GeneIDi2686712
KEGGigsu:GSU1812
PATRICifig|243231.5.peg.1849

Similar proteinsi

Entry informationi

Entry nameiSYR_GEOSL
AccessioniPrimary (citable) accession number: Q74C63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: February 28, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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