Q74C57 (APGM_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	GSU1818

Organism

Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

Taxonomic identifier

243231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402_B
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402_B
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402_B
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402_B		PRO_0000138154

Sequences

	Sequence		Length	Mass (Da)
	Q74C57 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: A178908E1D948F72	FASTA	399	43,249
	10 20 30 40 50 60 MKYIVLLGDG MSDEPMQELG GKTPLQAART PHMDAMARRG RIGLARTVPE GYPPGSDVAN 70 80 90 100 110 120 LSVFGYDPRA CYTGRSPLEA ASMGVELGSA DVAFRVNLVN LAPTRGTLVM NDYSAGHIST 130 140 150 160 170 180 AEGRELIEAI QGVMGTDEFQ FYPGVGYRHL MVWRNGKCGM TVVPPHDISG QSILEHLPKG 190 200 210 220 230 240 EGAERLIELM NSSQLVLNNH PQYRRRLEEG KVPANSIWLW GHGKAPRMAS FHEKFGLTGA 250 260 270 280 290 300 VISAVDLVRG IGVCAGLDVI KVEGATGYID TNYEGKVTAA LEALEAHDYV YLHVEAPDEA 310 320 330 340 350 360 GHGGNLEHKL KAIEDFDARV VGPIMAGMEK FGSYRILCTP DHPTPLRLKT HTDAPVPFVL 370 380 390 FSGETSENAG VAGYDEESAR SAGLVVEDGF RLMEMMLDR

References

[1]

"Genome of Geobacter sulfurreducens: metal reduction in subsurface environments." Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C., Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J., Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.L., Kolonay J.F. , Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R., Fraser C.M. Science 302:1967-1969(2003) [PubMed: 14671304] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51573 / DSM 12127 / PCA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017180 Genomic DNA. Translation: AAR35195.1.
RefSeq	NP_952868.1. NC_002939.4.
3D structure databases
ProteinModelPortal	Q74C57.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2686266.
GenomeReviews	Gene locus GSU1818 in contig AE017180_GR.
KEGG	gsu:GSU1818.
NMPDR	fig|243231.1.peg.1806.
PATRIC	22026493. VBIGeoSul17553_1855.
TIGR	GSU1818.
Phylogenomic databases
HOGENOM	HBG463247.
OMA	ANSIWLW.
PhylomeDB	Q74C57.
ProtClustDB	PRK04200.
Enzyme and pathway databases
BioCyc	GSUL243231:GSU_1818-MONOMER.
Family and domain databases
HAMAP	MF_01402_B. ApgM_B. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR013371. Homoserine_kinase_put. IPR006124. Metalloenzyme. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits.
KO	K15635.
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. ApgM. 1 hit. TIGR02535. Hyp_Hser_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_GEOSL

Accession

Primary (citable) accession number: Q74C57

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program