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Q74BH6 (NADK_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:GSU2065
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284NAD kinase HAMAP-Rule MF_00361
PRO_0000229640

Regions

Nucleotide binding67 – 682NAD By similarity
Nucleotide binding141 – 1422NAD By similarity
Nucleotide binding182 – 1876NAD By similarity

Sites

Active site671Proton acceptor By similarity
Binding site1521NAD By similarity
Binding site1691NAD By similarity
Binding site1711NAD By similarity
Binding site2411NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q74BH6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0168BD907A2DF45D

FASTA28430,999
        10         20         30         40         50         60 
MKKIAIFAKV HDPRCQGVAS ELIAWLEARG LIPLVEAHLA RHLGGRQGIV PEDIPVLADM 

        70         80         90        100        110        120 
AVVLGGDGTL ISAARLIGSR QIPILGVNLG SLGFLTEITL DELYPVLESC LSGDFQVTER 

       130        140        150        160        170        180 
MMLTVSVERN GEEICSHRVL NDVVINKGAL ARIIDMETEV SGIRLTTYKA DGLIISTPTG 

       190        200        210        220        230        240 
STGYSLSANG PIVHPSLECI TITPICPHTL TNRPIVLESS SGVTVWLRSK DEDVYLTLDG 

       250        260        270        280 
QVGMELKCGD AVHVRRAAHR TRLVMSRSRN YFEVLRTKLK WGER 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017180 Genomic DNA. Translation: AAR35441.1.
RefSeqNP_953114.1. NC_002939.5.

3D structure databases

ProteinModelPortalQ74BH6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243231.GSU2065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR35441; AAR35441; GSU2065.
GeneID2686010.
KEGGgsu:GSU2065.
PATRIC22026991. VBIGeoSul17553_2101.

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMAHPSIPGW.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycGSUL243231:GH27-2095-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_GEOSL
AccessionPrimary (citable) accession number: Q74BH6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families