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Protein

Catalase-peroxidase

Gene

katG

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei89 – 891Transition state stabilizerUniRule annotation
Active sitei93 – 931Proton acceptorUniRule annotation
Metal bindingi256 – 2561Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciGSUL243231:GH27-2130-MONOMER.

Protein family/group databases

PeroxiBasei2439. GsuCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:GSU2100
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Catalase-peroxidasePRO_0000354802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki92 ↔ 215Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-241)UniRule annotation
Cross-linki215 ↔ 241Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-92)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU2100.

Structurei

3D structure databases

ProteinModelPortaliQ74BE1.
SMRiQ74BE1. Positions 17-727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
InParanoidiQ74BE1.
KOiK03782.
OMAiNPMGGDF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74BE1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADNESRTG RRAAGGGTSN RQWWPNQLNL HILHQHSALS NPMGGDFNYA
60 70 80 90 100
DEFRKLDLAA VKKDLHALMT DSQEWWPADW GHYGGLFIRM AWHSAGTYRM
110 120 130 140 150
GDGRGGAGSG SQRLAPLNSW PDNVNLDKAR RLLWPIKQKY GRKISWADLM
160 170 180 190 200
ILAGNCALES MGFRIFGFGG GRVDVWEPEE DIYWGSEDTW LGDKRYSGDR
210 220 230 240 250
DLENPLAAVQ MGLIYVNPEG PNGEPDPVAS GRDVRETFAR MAMNDEETVA
260 270 280 290 300
LVAGGHTFGK CHGAGPATHV GPEPEAAPLE DQGLGWKSTF RSGKGGDAIG
310 320 330 340 350
SGLEGAWKPN PTTWDMGYLK VLFKYEWELV KSPAGANQWL AKDVADEDMV
360 370 380 390 400
VDAHDPSKKR RPMMTTADLS LRFDPIYEPI ARRYLANPEE FADAFARAWF
410 420 430 440 450
KLTHRDMGPR SRYLGPDVPA EELIWQDPVP AVTHQLIDRQ DIAALKGTIL
460 470 480 490 500
ASGLSIADLV ATAWASASTF RGSDKRGGAN GARIRLAPQK DWAVNQPARL
510 520 530 540 550
ATVLQALEGI RQEFNNAQSG GKQVSLADLI VLGGCAAVEQ AAKKAGHDVT
560 570 580 590 600
VPFTPGRADA SQEHTDAASF TVLEPVADGF RNYQKAKYAV TAEELLIDRA
610 620 630 640 650
QLLTLTAPEM TVLIGGMRVL NANYGQSKHG VFTRQPETLT NDFFVNLLDM
660 670 680 690 700
GTVWQPTAAD KDLFEGRDRV SGELKWTGTR VDLIFGSNSQ LRAVAEVYGC
710 720
ADSQEKFLND FVAAWNKVMN LDRFDLA
Length:727
Mass (Da):79,894
Last modified:July 5, 2004 - v1
Checksum:i87792DD45DAF70F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR35476.1.
RefSeqiNP_953149.1. NC_002939.5.
WP_010942744.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR35476; AAR35476; GSU2100.
GeneIDi2687840.
KEGGigsu:GSU2100.
PATRICi22027065. VBIGeoSul17553_2138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR35476.1.
RefSeqiNP_953149.1. NC_002939.5.
WP_010942744.1. NC_002939.5.

3D structure databases

ProteinModelPortaliQ74BE1.
SMRiQ74BE1. Positions 17-727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243231.GSU2100.

Protein family/group databases

PeroxiBasei2439. GsuCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAR35476; AAR35476; GSU2100.
GeneIDi2687840.
KEGGigsu:GSU2100.
PATRICi22027065. VBIGeoSul17553_2138.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
InParanoidiQ74BE1.
KOiK03782.
OMAiNPMGGDF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciGSUL243231:GH27-2130-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiKATG_GEOSL
AccessioniPrimary (citable) accession number: Q74BE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.