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Q74AZ0

- SYL_GEOSL

UniProt

Q74AZ0 - SYL_GEOSL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGSUL243231:GH27-2241-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:GSU2209
    OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
    Taxonomic identifieri243231 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000000577: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Leucine--tRNA ligasePRO_0000152020Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243231.GSU2209.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74AZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q74AZ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQERYIPKNV EGKWQEIWEE NKTFTVTEDP SKPKYYLLEM FPYPSGRIHM    50
    GHVRNYSIGD VVGRFKRMRG FNVLHPMGWD AFGMPAENAA IKHGSHPAKW 100
    TYENIDYMRS QLKKMGLSYD WGRELATCDV DYYKWEQKMF LEMYEKGLVY 150
    KKSSFVNWCP ACETVLANEQ VEDGCCWRCD SDVTQKELDQ WFFRITRYAE 200
    ELLEDTWNLP GWPERVLVMQ RNWIGKSFGC EIDFPVEGKV EKVKVFTTRQ 250
    DTLYGATFMS LAPEHPQALE LTTPERRAEV EAFIDKVKKT DKIKRTAEDF 300
    EKEGVFTGAY CINPVTNLRM PVYLANFVLL DYGTGAVMAV PTHDQRDFEF 350
    ARTYDLPLQV VIQPEGETLD PAAMTAAYTE VGTMVNSGPF NGMKSDEAKE 400
    KIADYLEQEG VGTKTVNYRL RDWGISRQRY WGNPIPVINC DICGVVPVPD 450
    KDLPVVLPMD AEFTGEGGNP LARVESFVNV TCPQCGAEAR RETDTMDTFV 500
    QSSWYFLRYC CPDFACGPID RARAGYWMPV DQYIGGIEHA VLHLLYSRFF 550
    TKALRDLGYV TVAEPFKNLL TQGMVIKDGA KMSKSKGNVV DPDALIERYG 600
    ADTARLFTLF AAPPEKDLDW SDQGVEGSFR FLNRVWRLVF EVLPFIGSAG 650
    KPDPAALGDG ARDLRRTVHK TIRKVTDDLD ERFHFNTAIS AVMELVNAIQ 700
    SFEPKNAPEN APVLREAVES VVQLLAPFVP HVAEELWESL GHQGGVEASG 750
    WPSYDPEATV EEELLIVVQV NGKLRGKVTV AVDAGEEQVK AAAFADDKVK 800
    PWLDGKQIRK AIYVPGKLLN IVVG 824
    Length:824
    Mass (Da):93,367
    Last modified:July 5, 2004 - v1
    Checksum:i5D5B9DB48DFCED55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR35585.1.
    RefSeqiNP_953258.1. NC_002939.5.

    Genome annotation databases

    EnsemblBacteriaiAAR35585; AAR35585; GSU2209.
    GeneIDi2687062.
    KEGGigsu:GSU2209.
    PATRICi22027275. VBIGeoSul17553_2241.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR35585.1 .
    RefSeqi NP_953258.1. NC_002939.5.

    3D structure databases

    ProteinModelPortali Q74AZ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243231.GSU2209.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAR35585 ; AAR35585 ; GSU2209 .
    GeneIDi 2687062.
    KEGGi gsu:GSU2209.
    PATRICi 22027275. VBIGeoSul17553_2241.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci GSUL243231:GH27-2241-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51573 / DSM 12127 / PCA.

    Entry informationi

    Entry nameiSYL_GEOSL
    AccessioniPrimary (citable) accession number: Q74AZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3