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Q74AX1 (RNC_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:GSU2228
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000228535

Regions

Domain16 – 145130RNase III
Domain172 – 24170DRBM

Sites

Active site621 Potential
Active site1341 By similarity
Metal binding581Magnesium By similarity
Metal binding1311Magnesium By similarity
Metal binding1341Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q74AX1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EC1068B65CD1E9ED

FASTA24827,017
        10         20         30         40         50         60 
MRETDEQPVA GGAASTEGLE TSIGYRFTDR RFLDEALTHR SWLNEVRSPT VPDNERLEFF 

        70         80         90        100        110        120 
GDAILGFCIG KMLLRHYPES REGALARMKS ALVGEETLAD LAAAVELGSY LRLGRGEERS 

       130        140        150        160        170        180 
GGRHRRSLLA NALEALLAAM YLDGGMAPVE RLVDAWFGPR LAGVAAGIKG RDFKTDFQEL 

       190        200        210        220        230        240 
AQAQYGGLPR YVLVDTSGPA HDLRFTVAAY VGERLLGQGT GRSKKEAEQA AARQCLERLE 


TGRCSAAP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017180 Genomic DNA. Translation: AAR35604.1.
RefSeqNP_953277.1. NC_002939.5.

3D structure databases

ProteinModelPortalQ74AX1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243231.GSU2228.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR35604; AAR35604; GSU2228.
GeneID2687587.
KEGGgsu:GSU2228.
PATRIC22027311. VBIGeoSul17553_2259.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246809.
KOK03685.
OMALTHKSCK.
OrthoDBEOG6T1WVS.
ProtClustDBCLSK828768.

Enzyme and pathway databases

BioCycGSUL243231:GH27-2260-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_GEOSL
AccessionPrimary (citable) accession number: Q74AX1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families