Q74AT9 (LPXB_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	GSU2261

Organism

Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

Taxonomic identifier

243231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Lipid-A-disaccharide synthase HAMAP MF_00392		PRO_0000255184

Sequences

	Sequence		Length	Mass (Da)
	Q74AT9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 636C4BCEB34FA5F1	FASTA	384	41,842
	10 20 30 40 50 60 MTENTSHRIM IVAGEASGDL HGAGLVREAL RLDPTLSFFG IGGPRMREAG VETLVDSSEM 70 80 90 100 110 120 AVVGIVEVLA HIGVISRAFM TLRQVIVSNP PDLLILIDYP DFNMLLARVA RRHGVKVLYY 130 140 150 160 170 180 ISPQVWAWRT GRVKTIGRLV DRMAVVFPFE VPFYERAGVP VSFVGHPLAD RVRPTMGRDE 190 200 210 220 230 240 ALASFGLDPG RRVVGLFPGS RRGEIAKLFP VILESAQQLR ERYPDIQFIL PLASSLTDGD 250 260 270 280 290 300 IAPLLAASGL DVTVTQDRVY DVMQVCDAII TVSGTVTLEI ALMGVPMVII YKVSPLTYQV 310 320 330 340 350 360 GKRLIRVDHI GICNIVAGER VVPELIQDDA SADRIAAEIG RYLDDPAYAE KTRAGLAMVK 370 380 EKLGTGGCSE RVAGIVLEML GKQV

References

[1]

"Genome of Geobacter sulfurreducens: metal reduction in subsurface environments." Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C., Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J., Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.L., Kolonay J.F. , Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R., Fraser C.M. Science 302:1967-1969(2003) [PubMed: 14671304] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51573 / DSM 12127 / PCA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017180 Genomic DNA. Translation: AAR35637.1.
RefSeq	NP_953310.1. NC_002939.4.
3D structure databases
ProteinModelPortal	Q74AT9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2685733.
GenomeReviews	Gene locus GSU2261 in contig AE017180_GR.
KEGG	gsu:GSU2261.
NMPDR	fig|243231.1.peg.2248.
PATRIC	22027377. VBIGeoSul17553_2292.
TIGR	GSU2261.
Phylogenomic databases
HOGENOM	HBG584837.
OMA	AEFAFIC.
PhylomeDB	Q74AT9.
ProtClustDB	PRK00025.
Enzyme and pathway databases
BioCyc	GSUL243231:GSU_2261-MONOMER.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_GEOSL

Accession

Primary (citable) accession number: Q74AT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program