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Q74AT9 (LPXB_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:GSU2261
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255184

Sequences

Sequence LengthMass (Da)Tools
Q74AT9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 636C4BCEB34FA5F1

FASTA38441,842
        10         20         30         40         50         60 
MTENTSHRIM IVAGEASGDL HGAGLVREAL RLDPTLSFFG IGGPRMREAG VETLVDSSEM 

        70         80         90        100        110        120 
AVVGIVEVLA HIGVISRAFM TLRQVIVSNP PDLLILIDYP DFNMLLARVA RRHGVKVLYY 

       130        140        150        160        170        180 
ISPQVWAWRT GRVKTIGRLV DRMAVVFPFE VPFYERAGVP VSFVGHPLAD RVRPTMGRDE 

       190        200        210        220        230        240 
ALASFGLDPG RRVVGLFPGS RRGEIAKLFP VILESAQQLR ERYPDIQFIL PLASSLTDGD 

       250        260        270        280        290        300 
IAPLLAASGL DVTVTQDRVY DVMQVCDAII TVSGTVTLEI ALMGVPMVII YKVSPLTYQV 

       310        320        330        340        350        360 
GKRLIRVDHI GICNIVAGER VVPELIQDDA SADRIAAEIG RYLDDPAYAE KTRAGLAMVK 

       370        380 
EKLGTGGCSE RVAGIVLEML GKQV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017180 Genomic DNA. Translation: AAR35637.1.
RefSeqNP_953310.1. NC_002939.5.

3D structure databases

ProteinModelPortalQ74AT9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243231.GSU2261.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR35637; AAR35637; GSU2261.
GeneID2685733.
KEGGgsu:GSU2261.
PATRIC22027377. VBIGeoSul17553_2292.

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMAIARMLVN.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycGSUL243231:GH27-2293-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_GEOSL
AccessionPrimary (citable) accession number: Q74AT9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways