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Q74AT9

- LPXB_GEOSL

UniProt

Q74AT9 - LPXB_GEOSL

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, GSU2261
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciGSUL243231:GH27-2293-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:GSU2261
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Lipid-A-disaccharide synthaseUniRule annotationPRO_0000255184Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU2261.

Structurei

3D structure databases

ProteinModelPortaliQ74AT9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q74AT9-1 [UniParc]FASTAAdd to Basket

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MTENTSHRIM IVAGEASGDL HGAGLVREAL RLDPTLSFFG IGGPRMREAG    50
VETLVDSSEM AVVGIVEVLA HIGVISRAFM TLRQVIVSNP PDLLILIDYP 100
DFNMLLARVA RRHGVKVLYY ISPQVWAWRT GRVKTIGRLV DRMAVVFPFE 150
VPFYERAGVP VSFVGHPLAD RVRPTMGRDE ALASFGLDPG RRVVGLFPGS 200
RRGEIAKLFP VILESAQQLR ERYPDIQFIL PLASSLTDGD IAPLLAASGL 250
DVTVTQDRVY DVMQVCDAII TVSGTVTLEI ALMGVPMVII YKVSPLTYQV 300
GKRLIRVDHI GICNIVAGER VVPELIQDDA SADRIAAEIG RYLDDPAYAE 350
KTRAGLAMVK EKLGTGGCSE RVAGIVLEML GKQV 384
Length:384
Mass (Da):41,842
Last modified:July 5, 2004 - v1
Checksum:i636C4BCEB34FA5F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR35637.1.
RefSeqiNP_953310.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR35637; AAR35637; GSU2261.
GeneIDi2685733.
KEGGigsu:GSU2261.
PATRICi22027377. VBIGeoSul17553_2292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR35637.1 .
RefSeqi NP_953310.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q74AT9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU2261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR35637 ; AAR35637 ; GSU2261 .
GeneIDi 2685733.
KEGGi gsu:GSU2261.
PATRICi 22027377. VBIGeoSul17553_2292.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci GSUL243231:GH27-2293-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiLPXB_GEOSL
AccessioniPrimary (citable) accession number: Q74AT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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