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Q74AT9

- LPXB_GEOSL

UniProt

Q74AT9 - LPXB_GEOSL

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciGSUL243231:GH27-2293-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:GSU2261
    OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
    Taxonomic identifieri243231 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000000577: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Lipid-A-disaccharide synthasePRO_0000255184Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243231.GSU2261.

    Structurei

    3D structure databases

    ProteinModelPortaliQ74AT9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiIARMLVN.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q74AT9-1 [UniParc]FASTAAdd to Basket

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    MTENTSHRIM IVAGEASGDL HGAGLVREAL RLDPTLSFFG IGGPRMREAG    50
    VETLVDSSEM AVVGIVEVLA HIGVISRAFM TLRQVIVSNP PDLLILIDYP 100
    DFNMLLARVA RRHGVKVLYY ISPQVWAWRT GRVKTIGRLV DRMAVVFPFE 150
    VPFYERAGVP VSFVGHPLAD RVRPTMGRDE ALASFGLDPG RRVVGLFPGS 200
    RRGEIAKLFP VILESAQQLR ERYPDIQFIL PLASSLTDGD IAPLLAASGL 250
    DVTVTQDRVY DVMQVCDAII TVSGTVTLEI ALMGVPMVII YKVSPLTYQV 300
    GKRLIRVDHI GICNIVAGER VVPELIQDDA SADRIAAEIG RYLDDPAYAE 350
    KTRAGLAMVK EKLGTGGCSE RVAGIVLEML GKQV 384
    Length:384
    Mass (Da):41,842
    Last modified:July 5, 2004 - v1
    Checksum:i636C4BCEB34FA5F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR35637.1.
    RefSeqiNP_953310.1. NC_002939.5.

    Genome annotation databases

    EnsemblBacteriaiAAR35637; AAR35637; GSU2261.
    GeneIDi2685733.
    KEGGigsu:GSU2261.
    PATRICi22027377. VBIGeoSul17553_2292.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR35637.1 .
    RefSeqi NP_953310.1. NC_002939.5.

    3D structure databases

    ProteinModelPortali Q74AT9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243231.GSU2261.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAR35637 ; AAR35637 ; GSU2261 .
    GeneIDi 2685733.
    KEGGi gsu:GSU2261.
    PATRICi 22027377. VBIGeoSul17553_2292.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi IARMLVN.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci GSUL243231:GH27-2293-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51573 / DSM 12127 / PCA.

    Entry informationi

    Entry nameiLPXB_GEOSL
    AccessioniPrimary (citable) accession number: Q74AT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3