ID   Q74AI2_GEOSL            Unreviewed;       727 AA.
AC   Q74AI2;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Methyl-accepting chemotaxis sensory transducer, class 40+24H {ECO:0000313|EMBL:AAR35746.1};
GN   Name=mcp64H-2 {ECO:0000313|EMBL:AAR35746.1};
GN   OrderedLocusNames=GSU2372 {ECO:0000313|EMBL:AAR35746.1};
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC   Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231 {ECO:0000313|EMBL:AAR35746.1, ECO:0000313|Proteomes:UP000000577};
RN   [1] {ECO:0000313|EMBL:AAR35746.1, ECO:0000313|Proteomes:UP000000577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA
RC   {ECO:0000313|Proteomes:UP000000577};
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.,
RA   Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M.,
RA   Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.,
RA   Khouri H., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R.,
RA   Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; AE017180; AAR35746.1; -; Genomic_DNA.
DR   RefSeq; NP_953419.1; NC_002939.5.
DR   RefSeq; WP_010943007.1; NC_002939.5.
DR   AlphaFoldDB; Q74AI2; -.
DR   SMR; Q74AI2; -.
DR   STRING; 243231.GSU2372; -.
DR   EnsemblBacteria; AAR35746; AAR35746; GSU2372.
DR   KEGG; gsu:GSU2372; -.
DR   PATRIC; fig|243231.5.peg.2399; -.
DR   eggNOG; COG0840; Bacteria.
DR   eggNOG; COG2972; Bacteria.
DR   HOGENOM; CLU_000445_107_27_7; -.
DR   InParanoid; Q74AI2; -.
DR   OrthoDB; 5523945at2; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   PANTHER; PTHR43531:SF11; METHYL-ACCEPTING CHEMOTAXIS PROTEIN 3; 1.
DR   PANTHER; PTHR43531; PROTEIN ICFG; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00304; HAMP; 2.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 3.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000577};
KW   Transducer {ECO:0000256|PROSITE-ProRule:PRU00284};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          227..279
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          368..604
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
SQ   SEQUENCE   727 AA;  77934 MW;  5FD20B188CA5E37C CRC64;
     MFKDMKLGYR LIGSFAIMAA IVAVTGFIGI RSIGMVGNRV SDLMQTRADQ QKLALQLQAA
     ERTSRVALLE AMMGHVDTRI LAANVESYRK NRDIFRRYSN ALLKGDPALG IRPDSVDTVM
     EEHAKALLDT WAEYEKVADR IIAYKSGVLS GSVSPSVLVE TRLISELSGA SEFVARDIDD
     LIETVKGLMQ VVGQETRQIR ASVSITFVIV IIGAAVLAFV FGVVATRNII RRVNMMVTAL
     NKGAEGDLTV RVTTDATDEL SLLGRDFNIM LEMLGELVRK VNRSLVEVGQ VSANIFEASR
     RVMAAAEVQA EGVSLTSSAV AEINTSIKEV SRGVDGLSLS ASETSSSILE MAASIEEVAV
     NVDSLAQAVD EVSSSVMEMA ASIKQIANSV VSLQDVTTTT ASSVAEMDSS IRQVEKNAME
     TASISEGVRR DAEMGKVSVE ATIAGINEIK RSSRITSEVI ETLSVRATDI GAILSVIDEV
     AEQTNLLALN AAIIAAQAGE HGKGFAVVAD EIKELAERTT SSTREIAQLI KGVQDETARA
     VEAIELAEKS IADGEALSQK SGEALAKIVT GVQGATAQVE SIARATMEQA KGSQMIRSAM
     ERVSDMIAQV AGATREQGKG SDMIMAAAER MKGLTSQVRT STREQSKVGA FIARSTENIT
     DMIQQIKRAC DEQSRGSDQI IRAVEDIQES TSTNLGSARM MDDAVSRLSR QLEALERGMS
     SFKVENR
//