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Protein

Acetate kinase

Gene

ackA

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA), Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Active sitei148Proton donor/acceptorUniRule annotation1
Sitei180Transition state stabilizerUniRule annotation1
Sitei241Transition state stabilizerUniRule annotation1
Metal bindingi387MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 212ATPUniRule annotation5
Nucleotide bindingi283 – 285ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-2957-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:GSU2707
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075631 – 421Acetate kinaseAdd BLAST421

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU2707.

Structurei

3D structure databases

ProteinModelPortaliQ749N5.
SMRiQ749N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
InParanoidiQ749N5.
KOiK00925.
OMAiFMMQKEN.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q749N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIILALNCGS SSVKYQLFDW ERKEVVAKGM VERVIIGDSF IMHEVPGRET
60 70 80 90 100
YRKEYECPDH QVAIDLIIRT VVDADHGVLK DINEISAVGH RVVHGGEMFT
110 120 130 140 150
RSVLIDEKVL DAVKEVQHLA PLHNPPNIAG IEAAQAVLPH VPHVAIFDTA
160 170 180 190 200
FHQTMPEHAY LYPLPYEWYE KYGVRRYGFH GTSHLYVSKR AAVLLGKTPS
210 220 230 240 250
ECNIITMHIG NGVSHCAIKG GVSVDTSMGL TPLEGAVMGT RCGDIDPAIP
260 270 280 290 300
AFMMQKENLS AKEIDSILNK KSGVLGVTGR FTDRRDVIEH ASNGDHRCKV
310 320 330 340 350
ALDIEAYRLK KYIGTYMAVL GRLDAVVFTA GVGEMGWPIR EKTIEGLEGI
360 370 380 390 400
GIKLDRERNK GAMTRKRESL ITTDDSPIKV FVIPTDEELV FTEDVVAILN
410 420
GTYTDHMNFD YSFARTDFVR K
Length:421
Mass (Da):46,894
Last modified:July 5, 2004 - v1
Checksum:i4A66B254288FDB45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA. Translation: AAR36079.1.
RefSeqiNP_953752.1. NC_002939.5.
WP_010943345.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR36079; AAR36079; GSU2707.
GeneIDi2685340.
KEGGigsu:GSU2707.
PATRICifig|243231.5.peg.2737.

Similar proteinsi

Entry informationi

Entry nameiACKA_GEOSL
AccessioniPrimary (citable) accession number: Q749N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome