Q748X6 (ARGC_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	GSU2874

Organism

Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

Taxonomic identifier

243231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112408
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q748X6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5F1BA016B6843120	FASTA	346	36,961
	10 20 30 40 50 60 MLKVAVVGAS GYTGVELLRI LHCHPEVAVT CITSEQSAGK PVSDLFPSLR GRYAQVLENL 70 80 90 100 110 120 EPIRVAEKAD IIFTALPHKA AMEVVPTFLK LGKRVIDLSA DYRFNDAATY EQWYEPHMNP 130 140 150 160 170 180 HLLPKAVYGL PEVRRAAVKG AKLVANPGCY PTSVILGLQP LLKHKLIETA GIISDSASGV 190 200 210 220 230 240 SGAGRGAKVD NLYCEVNEGF KAYGVGGVHR HTPEMEQELS LLADERITIT FTPHLAPMDR 250 260 270 280 290 300 GILSTIYGRL LTPATTAELA GLYAEFYGGE PFVRVLPAGG VPSTAHVRGS NFCDIGVVVD 310 320 330 340 QRTGRVIVVS AIDNLVKGAS GQAVQNMNIM CGLPEGLGLE GLALVP

References

[1]

"Genome of Geobacter sulfurreducens: metal reduction in subsurface environments." Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.C., Heidelberg J.F., Wu D., Wu M., Ward N.L., Beanan M.J., Dodson R.J., Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.L., Kolonay J.F. , Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M., Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.F., Khouri H.M., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R., Fraser C.M. Science 302:1967-1969(2003) [PubMed: 14671304] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51573 / DSM 12127 / PCA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017180 Genomic DNA. Translation: AAR36266.1.
RefSeq	NP_953916.1. NC_002939.4.
3D structure databases
ProteinModelPortal	Q748X6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2688689.
GenomeReviews	Gene locus GSU2874 in contig AE017180_GR.
KEGG	gsu:GSU2874.
NMPDR	fig|243231.1.peg.2854.
PATRIC	22028609. VBIGeoSul17553_2902.
TIGR	GSU2874.
Phylogenomic databases
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	Q748X6.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	GSUL243231:GSU_2874-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_GEOSL

Accession

Primary (citable) accession number: Q748X6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program