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Q748D8 (DDL_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:GSU3066
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341102

Regions

Domain107 – 303197ATP-grasp
Nucleotide binding133 – 18856ATP By similarity

Sites

Metal binding2561Magnesium or manganese 1 By similarity
Metal binding2691Magnesium or manganese 1 By similarity
Metal binding2691Magnesium or manganese 2 By similarity
Metal binding2711Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q748D8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 210220D430EC14A7

FASTA31633,930
        10         20         30         40         50         60 
MTRDELKTTK IGVLMGGLSA EREVSLASGG AVLKALQSRG YDAVPVDVGR DLPQVLVREW 

        70         80         90        100        110        120 
IDVAFICLHG RYGEDGTVQG LLELMGIPYT GSGVLASALA MNKIVAKEVF AARGLTIAPY 

       130        140        150        160        170        180 
RVVRRGETVD PVAEGFGYPV VVKPSQEGSS VGVSIVKSPE ELPSALELAF RYDDDILVER 

       190        200        210        220        230        240 
FIKGREIQIG ILDDRAMGAI EIVPVNEFYD FEAKYTAGKA EHICPPVLPA ELHRRLLAEG 

       250        260        270        280        290        300 
EAAHRALGCS GYSRVDFLVT EGGECYLLEV NTLPGMTALS LLPEIALKES GIGFEDLVER 

       310 
ILISAELKIK GEGAGS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017180 Genomic DNA. Translation: AAR36458.1.
RefSeqNP_954108.1. NC_002939.5.

3D structure databases

ProteinModelPortalQ748D8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243231.GSU3066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR36458; AAR36458; GSU3066.
GeneID2686321.
KEGGgsu:GSU3066.
PATRIC22028983. VBIGeoSul17553_3089.

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.
OrthoDBEOG6ND0KB.
ProtClustDBCLSK829085.

Enzyme and pathway databases

BioCycGSUL243231:GH27-3105-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_GEOSL
AccessionPrimary (citable) accession number: Q748D8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways