Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q747A2 (SYC_GEOSL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine--tRNA ligase

EC=6.1.1.16
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name=CysRS
Gene names
Name:cysS
Ordered Locus Names:GSU3365
OrganismGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) [Reference proteome] [HAMAP]
Taxonomic identifier243231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length481 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). HAMAP-Rule MF_00041

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00041

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00041

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00041.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcysteinyl-tRNA aminoacylation

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcytosol

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cysteine-tRNA ligase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 481481Cysteine--tRNA ligase HAMAP-Rule MF_00041
PRO_0000159402

Regions

Motif31 – 4111"HIGH" region HAMAP-Rule MF_00041
Motif266 – 2705"KMSKS" region HAMAP-Rule MF_00041

Sites

Metal binding291Zinc By similarity
Metal binding2091Zinc By similarity
Metal binding2341Zinc By similarity
Metal binding2381Zinc By similarity
Binding site2691ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q747A2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: AB45190A2CF6B25A

FASTA48153,912
        10         20         30         40         50         60 
MALRVYNTLS GTKEDFVTLE PGRVKMYVCG VTVYDHCHIG HARANVVFDM IYRYLRHAGY 

        70         80         90        100        110        120 
EVTYVRNYTD VDDKIINRAN KEGVPFNVIS ERFIAEFDRD MAALGLDLPT YQPKATEHIA 

       130        140        150        160        170        180 
EMIQVIERLV AKGFAYAADG DVYFSVEAFD QYLKLSKRNL EEMQAGARIE VGEKKRHPMD 

       190        200        210        220        230        240 
FALWKGSKPG EPYWDSPWGQ GRPGWHIECS AMSMKYLGET FDIHGGGKDL VFPHHENEIA 

       250        260        270        280        290        300 
QSEAANGKPF ARYWIHNGFV NINAEKMSKS LGNFFTIKEV LESYDAEVLR FFLLSAHYRS 

       310        320        330        340        350        360 
PIDFSDQNLK EAAAGLERIY NALAGIDEAV AADGTGAGRI DEELAEKAAG LPTRFREAMD 

       370        380        390        400        410        420 
DDFNTAQALG YVFDLVRAVN RVLAEGEIDR AVLASAREAI DRVGAVLGLF TSEPGAFVER 

       430        440        450        460        470        480 
LKSRKAAALP IEAAEIERLI EERNAARKAR DFRRADEIRD TLAAQGILLL DSAQGTTWKV 


K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017180 Genomic DNA. Translation: AAR36755.1.
RefSeqNP_954405.1. NC_002939.5.

3D structure databases

ProteinModelPortalQ747A2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243231.GSU3365.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAR36755; AAR36755; GSU3365.
GeneID2688225.
KEGGgsu:GSU3365.
PATRIC22029585. VBIGeoSul17553_3387.

Phylogenomic databases

eggNOGCOG0215.
HOGENOMHOG000245250.
KOK01883.
OMAQIDIHAG.
OrthoDBEOG6RVFXC.
ProtClustDBPRK00260.

Enzyme and pathway databases

BioCycGSUL243231:GH27-3404-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00041. Cys_tRNA_synth.
InterProIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR10890. PTHR10890. 1 hit.
PfamPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00983. TRNASYNTHCYS.
SMARTSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00435. cysS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYC_GEOSL
AccessionPrimary (citable) accession number: Q747A2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries