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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73SubstrateUniRule annotation1
Metal bindingi221ManganeseUniRule annotation1
Metal bindingi241Manganese; via tele nitrogenUniRule annotation1
Binding sitei263SubstrateUniRule annotation1
Active sitei265UniRule annotation1
Metal bindingi292ManganeseUniRule annotation1
Binding sitei384GTPUniRule annotation1
Binding sitei415GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi264 – 269GTPUniRule annotation6
Nucleotide bindingi508 – 511GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-3628-MONOMER
UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:GSU3385
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001036051 – 618Phosphoenolpyruvate carboxykinase [GTP]Add BLAST618

Proteomic databases

PRIDEiQ746Y3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU3385

Structurei

3D structure databases

ProteinModelPortaliQ746Y3
SMRiQ746Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 214Substrate bindingUniRule annotation3
Regioni382 – 384Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0M Bacteria
COG1274 LUCA
HOGENOMiHOG000191700
InParanoidiQ746Y3
KOiK01596
OMAiCWLALTD
OrthoDBiPOG091H0B4F

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR018091 PEP_carboxykin_GTP_CS
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
PROSITEiView protein in PROSITE
PS00505 PEPCK_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q746Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYELPNNEK LLKWVEEVAI LCEPDRIHWC DGSQEEYDEL CELLVQNGTF
60 70 80 90 100
RKLNPEKRPN SYLAWSDPID VARVEDRTFI CSLSKQDAGP TNNWMNPKEM
110 120 130 140 150
KEKLLGLFKG CMKGRTMYVI PFSMGPLGSP IAKIGVEITD SPYVVVNMRI
160 170 180 190 200
MTRMGKKVLD ILGEQGEFVP CLHSVGAPLE QGQKDSTWPC NKEKYIVHFP
210 220 230 240 250
EERSIWSFGS GYGGNALLGK KCLALRIASK QGKDEGWLAE HMLILGVESP
260 270 280 290 300
TGDKTYVGAA FPSACGKTNF AMLIPPKPLQ DKGWKVTTIG DDIAWIKPGP
310 320 330 340 350
DGQVYAINPE YGYFGVAPGT NVKTNPNAMA SCSANTIFTN VALTPDDDVW
360 370 380 390 400
WEGMTDEPPA QLTDWQGNPW TPDCGRPAAH PNARFTSPAS QCPSIDPDWE
410 420 430 440 450
NPKGVPMSAF IFGGRRKDTV PLVYQAFNWS NGVYLAATLG SETTAAAVGA
460 470 480 490 500
VGNVRRDPFA MLPFCGYHMA DYFGHWLQFG RSIPRPPRIF SVNWFRKDAN
510 520 530 540 550
GKFIWPGYGD NMRVLKWIVE RVQGKAGAVE SPLGWMPRYE DMDWDGLDMP
560 570 580 590 600
REKFNELTSV DRDVWQNELI SHEELFVKLF DRLPKEFLHM RELILSSLWR
610
SPEHWEQIGD VHPEGWNE
Length:618
Mass (Da):69,613
Last modified:July 5, 2004 - v1
Checksum:i2D790FCF9D4692C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR36775.1
RefSeqiNP_954425.1, NC_002939.5
WP_010943996.1, NC_002939.5

Genome annotation databases

EnsemblBacteriaiAAR36775; AAR36775; GSU3385
GeneIDi2688197
KEGGigsu:GSU3385
PATRICifig|243231.5.peg.3407

Similar proteinsi

Entry informationi

Entry nameiPCKG_GEOSL
AccessioniPrimary (citable) accession number: Q746Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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