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Q746Y3

- PCKG_GEOSL

UniProt

Q746Y3 - PCKG_GEOSL

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene
pckG, GSU3385
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731Substrate By similarity
Binding sitei214 – 2141Substrate; via amide nitrogen By similarity
Metal bindingi221 – 2211Manganese By similarity
Binding sitei221 – 2211Substrate By similarity
Metal bindingi241 – 2411Manganese; via tele nitrogen By similarity
Binding sitei263 – 2631Substrate By similarity
Active sitei265 – 2651 By similarity
Metal bindingi292 – 2921Manganese By similarity
Binding sitei384 – 3841GTP By similarity
Binding sitei415 – 4151GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi264 – 2696GTP By similarity
Nucleotide bindingi508 – 5114GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSUL243231:GH27-3424-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:GSU3385
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000000577: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Phosphoenolpyruvate carboxykinase [GTP]UniRule annotationPRO_0000103605Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243231.GSU3385.

Structurei

3D structure databases

ProteinModelPortaliQ746Y3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni382 – 3843Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q746Y3-1 [UniParc]FASTAAdd to Basket

« Hide

MSYELPNNEK LLKWVEEVAI LCEPDRIHWC DGSQEEYDEL CELLVQNGTF    50
RKLNPEKRPN SYLAWSDPID VARVEDRTFI CSLSKQDAGP TNNWMNPKEM 100
KEKLLGLFKG CMKGRTMYVI PFSMGPLGSP IAKIGVEITD SPYVVVNMRI 150
MTRMGKKVLD ILGEQGEFVP CLHSVGAPLE QGQKDSTWPC NKEKYIVHFP 200
EERSIWSFGS GYGGNALLGK KCLALRIASK QGKDEGWLAE HMLILGVESP 250
TGDKTYVGAA FPSACGKTNF AMLIPPKPLQ DKGWKVTTIG DDIAWIKPGP 300
DGQVYAINPE YGYFGVAPGT NVKTNPNAMA SCSANTIFTN VALTPDDDVW 350
WEGMTDEPPA QLTDWQGNPW TPDCGRPAAH PNARFTSPAS QCPSIDPDWE 400
NPKGVPMSAF IFGGRRKDTV PLVYQAFNWS NGVYLAATLG SETTAAAVGA 450
VGNVRRDPFA MLPFCGYHMA DYFGHWLQFG RSIPRPPRIF SVNWFRKDAN 500
GKFIWPGYGD NMRVLKWIVE RVQGKAGAVE SPLGWMPRYE DMDWDGLDMP 550
REKFNELTSV DRDVWQNELI SHEELFVKLF DRLPKEFLHM RELILSSLWR 600
SPEHWEQIGD VHPEGWNE 618
Length:618
Mass (Da):69,613
Last modified:July 5, 2004 - v1
Checksum:i2D790FCF9D4692C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR36775.1.
RefSeqiNP_954425.1. NC_002939.5.

Genome annotation databases

EnsemblBacteriaiAAR36775; AAR36775; GSU3385.
GeneIDi2688197.
KEGGigsu:GSU3385.
PATRICi22029625. VBIGeoSul17553_3407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017180 Genomic DNA. Translation: AAR36775.1 .
RefSeqi NP_954425.1. NC_002939.5.

3D structure databases

ProteinModelPortali Q746Y3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243231.GSU3385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAR36775 ; AAR36775 ; GSU3385 .
GeneIDi 2688197.
KEGGi gsu:GSU3385.
PATRICi 22029625. VBIGeoSul17553_3407.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci GSUL243231:GH27-3424-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51573 / DSM 12127 / PCA.

Entry informationi

Entry nameiPCKG_GEOSL
AccessioniPrimary (citable) accession number: Q746Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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