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Q746Y3

- PCKG_GEOSL

UniProt

Q746Y3 - PCKG_GEOSL

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731SubstrateUniRule annotation
    Binding sitei214 – 2141Substrate; via amide nitrogenUniRule annotation
    Metal bindingi221 – 2211ManganeseUniRule annotation
    Binding sitei221 – 2211SubstrateUniRule annotation
    Metal bindingi241 – 2411Manganese; via tele nitrogenUniRule annotation
    Binding sitei263 – 2631SubstrateUniRule annotation
    Active sitei265 – 2651UniRule annotation
    Metal bindingi292 – 2921ManganeseUniRule annotation
    Binding sitei384 – 3841GTPUniRule annotation
    Binding sitei415 – 4151GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi264 – 2696GTPUniRule annotation
    Nucleotide bindingi508 – 5114GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGSUL243231:GH27-3424-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:GSU3385
    OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
    Taxonomic identifieri243231 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000000577: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 618618Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103605Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243231.GSU3385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ746Y3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni382 – 3843Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q746Y3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYELPNNEK LLKWVEEVAI LCEPDRIHWC DGSQEEYDEL CELLVQNGTF    50
    RKLNPEKRPN SYLAWSDPID VARVEDRTFI CSLSKQDAGP TNNWMNPKEM 100
    KEKLLGLFKG CMKGRTMYVI PFSMGPLGSP IAKIGVEITD SPYVVVNMRI 150
    MTRMGKKVLD ILGEQGEFVP CLHSVGAPLE QGQKDSTWPC NKEKYIVHFP 200
    EERSIWSFGS GYGGNALLGK KCLALRIASK QGKDEGWLAE HMLILGVESP 250
    TGDKTYVGAA FPSACGKTNF AMLIPPKPLQ DKGWKVTTIG DDIAWIKPGP 300
    DGQVYAINPE YGYFGVAPGT NVKTNPNAMA SCSANTIFTN VALTPDDDVW 350
    WEGMTDEPPA QLTDWQGNPW TPDCGRPAAH PNARFTSPAS QCPSIDPDWE 400
    NPKGVPMSAF IFGGRRKDTV PLVYQAFNWS NGVYLAATLG SETTAAAVGA 450
    VGNVRRDPFA MLPFCGYHMA DYFGHWLQFG RSIPRPPRIF SVNWFRKDAN 500
    GKFIWPGYGD NMRVLKWIVE RVQGKAGAVE SPLGWMPRYE DMDWDGLDMP 550
    REKFNELTSV DRDVWQNELI SHEELFVKLF DRLPKEFLHM RELILSSLWR 600
    SPEHWEQIGD VHPEGWNE 618
    Length:618
    Mass (Da):69,613
    Last modified:July 5, 2004 - v1
    Checksum:i2D790FCF9D4692C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR36775.1.
    RefSeqiNP_954425.1. NC_002939.5.

    Genome annotation databases

    EnsemblBacteriaiAAR36775; AAR36775; GSU3385.
    GeneIDi2688197.
    KEGGigsu:GSU3385.
    PATRICi22029625. VBIGeoSul17553_3407.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017180 Genomic DNA. Translation: AAR36775.1 .
    RefSeqi NP_954425.1. NC_002939.5.

    3D structure databases

    ProteinModelPortali Q746Y3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243231.GSU3385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAR36775 ; AAR36775 ; GSU3385 .
    GeneIDi 2688197.
    KEGGi gsu:GSU3385.
    PATRICi 22029625. VBIGeoSul17553_3407.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci GSUL243231:GH27-3424-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51573 / DSM 12127 / PCA.

    Entry informationi

    Entry nameiPCKG_GEOSL
    AccessioniPrimary (citable) accession number: Q746Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3