Reviewed, UniProtKB/Swiss-Prot Q746M5 (SURE2_THET2)

Names and origin

Protein names

Recommended name:
    5'-nucleotidase surE 2
    EC=3.1.3.5
Alternative name(s):
    Nucleoside 5'-monophosphate phosphohydrolase 2

Gene names

Name:	surE2
Ordered Locus Names:	TT_P0028

Encoded on

Plasmid pTT27

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity.
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	5'-nucleotidase surE 2 HAMAP MF_00060		PRO_0000235661
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	39	1	Divalent metal cation By similarity
	Metal binding	96	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q746M5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: DAC7BA445EACCD8E	FASTA	244	26,534
	10 20 30 40 50 60 MRILVTNDDG IYSPGLWALA EAASQFGEVF VAAPDTEQSA TGHAITIAHP VRAYPHPAPL 70 80 90 100 110 120 HGPHFPAYQV RGTPADCVAL GLHLFGPVDL VLSGVNLGSN LGHEIWHSGT VAAAKQGYLF 130 140 150 160 170 180 GLSAAAFSVP LNGEVPDFAG LRPWLLRTLE TLLRLERPFL VNVNLPLRPK GFLWTRQSVR 190 200 210 220 230 240 AYEGVVIPGE DPMGRPFYWF ASRPLKEAEE GTDRWAVAQG FVSATPLRLD LTDETRLQPA LAQE

References

[1]

"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017222 Genomic DNA. Translation: AAS82358.1.
RefSeq	YP_006011.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q746M5.
Genome annotation databases
GeneID	2776601.
GenomeReviews	Gene locus TT_P0028 in contig AE017222_GR.
KEGG	tth:TT_P0028.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q746M5.
OMA	PGLWALA.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_P0028-MON.
Family and domain databases
HAMAP	MF_00060. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
ProDom	PD005378. SurE. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00087. surE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE2_THET2

Accession

Primary (citable) accession number: Q746M5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)