Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q744V3

- SYL_MYCPA

UniProt

Q744V3 - SYL_MYCPA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei740 – 7401ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-51-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MAP_0048
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 969969Leucine--tRNA ligasePRO_0000152048Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP0048.

Structurei

3D structure databases

ProteinModelPortaliQ744V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi78 – 8912"HIGH" regionAdd
BLAST
Motifi737 – 7415"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q744V3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTESPTTSPA TGSGAAAPDS DAPPYRYTAA LAGRIEGSWQ DTWAKLGTFN
60 70 80 90 100
VPNPVGSLAP TDGTPVPEDK LFVQDMFPYP SGEGLHVGHP LGYIATDVYA
110 120 130 140 150
RYFRMTGRNV LHALGFDAFG LPAEQYAVQT GTHPRTRTEA NVVNFRRQLG
160 170 180 190 200
RLGLGHDSRR SFSTTDVEFY KWTQWIFLQI YNAWFDPAAN KARPIAELVA
210 220 230 240 250
EFDSGARSLD DGRNWSELSA GERADVIDSH RLVYRADSMV NWCPGLGTVL
260 270 280 290 300
ANEEVTADGR SDRGNFPVFR KRLRQWMMRI TAYSDRLLDD LDLLDWPEPV
310 320 330 340 350
KTMQRNWIGR STGAKALFAA TGADGAALDI EVFTTRPDTL FGATYMVLAP
360 370 380 390 400
EHELVDELVA PAWPDGTDPR WTYGAATPGE SVAAYRRAIA SKSDLERQES
410 420 430 440 450
KAKTGVFLGS YATNPTNGKP VPIFIADYVL AGYGTGAIMA VPGHDQRDWD
460 470 480 490 500
FAHEFGLPIV EVIAGGDISE GAYAGDGVLV NSGYLDGLDV AAAKEAITAR
510 520 530 540 550
LEAEGRGCAR VEYKLRDWLF ARQRYWGEPF PIVYDSDGRP HALDEAALPV
560 570 580 590 600
ELPDVPDYSP VLFDPDDADS EPSPPLAKAT DWVHVELDLG DGLKPYSRDT
610 620 630 640 650
NVMPQWAGSS WYELRYTDPH NSERFCAKEN EAYWMGPRPA EHGPQDPGGV
660 670 680 690 700
DLYVGGAEHA VLHLLYARFW HKVLYDLGHV SSREPYRRLV NQGYIQAFAY
710 720 730 740 750
TDSRGSYVPA EEVVERDGRF FYRGPDGEIE VFQEFGKIGK SLKNSISPDE
760 770 780 790 800
ICDDYGADTL RVYEMSMGPL EASRPWATKD VVGAHRFLQR VWRLVVDEQT
810 820 830 840 850
GETRVVDGAG RDLPTGTLRL LHRTIAGVSE DYAALRNNTA VAKLIEYTNH
860 870 880 890 900
LTKEHRDAVP RAAVEPLVLM LAPLAPHMAE ELWLRLGHTT SLAHGPFPVA
910 920 930 940 950
DPAYLVEDTV EYPVQVNGKV RGRVTVAADA DRDTLEAAAL ADEKVLAFLA
960
GAQPRKVIVV PGRLVNLVV
Length:969
Mass (Da):106,918
Last modified:July 5, 2004 - v1
Checksum:iC1D2A396E4833CA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS02365.1.
RefSeqiNP_958982.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS02365; AAS02365; MAP_0048.
GeneIDi2718110.
KEGGimpa:MAP0048.
PATRICi17992408. VBIMycAvi108102_0052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS02365.1 .
RefSeqi NP_958982.1. NC_002944.2.

3D structure databases

ProteinModelPortali Q744V3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP0048.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS02365 ; AAS02365 ; MAP_0048 .
GeneIDi 2718110.
KEGGi mpa:MAP0048.
PATRICi 17992408. VBIMycAvi108102_0052.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MAVI262316:GCQR-51-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiSYL_MYCPA
AccessioniPrimary (citable) accession number: Q744V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3