Q744Q8 (Q744Q8_MYCPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL AAS02323.1
Ordered Locus Names:	MAP_0006

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	839 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q744Q8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E199EDE284F68539	FASTA	839	92,312
	10 20 30 40 50 60 MTDTTLPPGG DAADRVEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM 70 80 90 100 110 120 YDSGFRPDRS HAKSARSVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSP 130 140 150 160 170 180 GNDPPAAMRY TEARLTPLAM EMLREIDEET VDFIPNYDGR VQEPTVLPSR FPNLLANGSG 190 200 210 220 230 240 GIAVGMATNI PPHNLGELAE AVFWALDNYE ADEEATLAAV MERVKGPDFP TSGLIVGTQG 250 260 270 280 290 300 IADAYKTGRG SIRMRGVVEV EEDSRGRTSL VITELPYQVN HDNFITSIAE QVRDGKLAGI 310 320 330 340 350 360 SNIEDQSSDR VGLRIVIELK RDAVAKVVLN NLYKHTQLQT SFGANMLAIV DGVPRTLRLD 370 380 390 400 410 420 QLIRHYVDHQ LDVIVRRTTY RLRKANERAH ILRGLVKALD ALDEVIALIR ASETVDIARQ 430 440 450 460 470 480 GLIELLDIDE IQAQAILDMQ LRRLAALERQ RIIDDLAKIE AEIADLEDIL AKPERQRGIV 490 500 510 520 530 540 RDELAEIVEK HGDARRTRIV AADGDVSDED LIAREDVVVT ITETGYAKRT KTDLYRSQKR 550 560 570 580 590 600 GGKGVQGAGL NQDDIVRHFF VCSTHDWILF FTTQGRVYRA KAYELPEASR TARGQHVANL 610 620 630 640 650 660 LAFQPEERIA QVIQIRSYED APYLVLATRN GLVKKTKLTD FDSNRSGGIV AINLRDNDEL 670 680 690 700 710 720 VGAVLCSAED DLLLVSANGQ SIRFSATDEA LRPMGRATSG VQGMRFNADD YLLSLNVVRE 730 740 750 760 770 780 GTYLLVATSG GYAKRTAIEE YPVQGRGGKG VLTVMYDRRR GRLVGALIVD EDSELYAITS 790 800 810 820 830 GGGVIRTAAG QVRKAGRQTK GVRLMNLGEG DTLLAIARNA EEAADEAVDE SDGAAGSDG

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS02323.1.
RefSeq	NP_958940.1. NC_002944.2.
3D structure databases
HSSP	HSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortal	Q744Q8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000039935; EBMYCP00000038324; EBMYCG00000039930.
GeneID	2720426.
GenomeReviews	Gene locus MAP_0006 in contig AE016958_GR.
KEGG	mpa:MAP0006.
NMPDR	fig|262316.1.peg.6.
PATRIC	17992312. VBIMycAvi108102_0007.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016653.
HOGENOM	HBG635183.
OMA	TGRGRIY.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit. G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q744Q8_MYCPA

Accession

Primary (citable) accession number: Q744Q8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)