ID   Q744G6_MYCPA            Unreviewed;       736 AA.
AC   Q744G6;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 111.
DE   RecName: Full=Stage II sporulation protein E {ECO:0008006|Google:ProtNLM};
GN   OrderedLocusNames=MAP_0375c {ECO:0000313|EMBL:AAS02692.1};
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS02692.1, ECO:0000313|Proteomes:UP000000580};
RN   [1] {ECO:0000313|EMBL:AAS02692.1, ECO:0000313|Proteomes:UP000000580}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
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DR   EMBL; AE016958; AAS02692.1; -; Genomic_DNA.
DR   RefSeq; WP_003873323.1; NZ_CP106873.1.
DR   AlphaFoldDB; Q744G6; -.
DR   STRING; 262316.MAP_0375c; -.
DR   KEGG; mpa:MAP_0375c; -.
DR   eggNOG; COG2172; Bacteria.
DR   eggNOG; COG2202; Bacteria.
DR   eggNOG; COG2208; Bacteria.
DR   HOGENOM; CLU_000445_43_2_11; -.
DR   Proteomes; UP000000580; Chromosome.
DR   CDD; cd16936; HATPase_RsbW-like; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 1.10.1240.30; KaiA/RbsU domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR017944; KaiA/RbsU_helical_domain_sf.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR014787; PSer_Pase_RsbU_N.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF13581; HATPase_c_2; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   Pfam; PF08673; RsbU_N; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000580}.
FT   DOMAIN          107..149
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          177..229
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
SQ   SEQUENCE   736 AA;  79771 MW;  A83802F18625FBDC CRC64;
     MSDDNDFHDQ YARALRAYLA SRDEASLAVG HELGRRALQE QISLLEIIEQ HVRLVFEISQ
     DVRIDAPIAL EFLLQLLVPL DVATRGFIDG NRRYAEQRAR AEGLADRDKF RNALVNSLQE
     GFFVADHEGS VIEVNNAFIE ILGFPAEGLP YRWPHPWLVD PKTASEQIGV VLRTGSAEYE
     TPIRHADGHL AWVKVSINAV KDSGSDRDAY VGTIRDVTAE RAFAARESAV LRLATAVAVA
     KSVDELLSIT LDECSTAIDV QRVVAVSWPS GDGDPAVQVA GRPAASSWRE LDPWLRDTFA
     EARHQLPLTA KTVDHPDNPG KSRGLVAVLS GAGDLALWLE LRTPRWVSGE DRLLVTVLIG
     HLSLALQHVR QFENARETSL TLQRAMLPPV QPPPGFAVRY EPAVPPLEIG GDWYDVLPIG
     DHRIGIVVGD CVGRGLPAAA IMGQLRSSAR ALLINGAEPA VLLDQLDSAA SLIPNAYCTT
     VFLAILDTET GVLQYSNAGH MPAVLAGPEP GTTTLLTDAA SVPLAVRRED PRPQATRLLP
     PGSTLMLFTD GLVERKHEPI DDGIGRAAEV LAQTMTLPLD TVADEVLREL APAAGYDDDV
     AMVIYRHQQS PLRIETAATA DQLVRIRHRL ADWLGAAGIT GELAADIVLV VNEACTNCVE
     HAYRGFVAGT MVLDARLGEG EVHTRITDYG SWKTPAANPV NSGRGLPLMK ALSQAMELRT
     SATGTVADIT FRRPAE
//