Q744D4 (Q744D4_MYCPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acs EMBL AAS02724.1
Synonyms:	acsA HAMAP MF_01123
Ordered Locus Names:	MAP_0407c

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	650 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	524	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	616	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q744D4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 55B26AA0128EF442	FASTA	650	71,449
	10 20 30 40 50 60 MTASNTASPA SYPPPPQFVE QANADEQLYR EAERDRLTFW AEQANRLSWA TPFTEVLDWS 70 80 90 100 110 120 RAPFAEWFAD GTLNVAYNCV DRHVQAGHGD RVAIHWEGES PGDQRSLTYS ELYTQVCKAA 130 140 150 160 170 180 NALTDLGLVA GDRVAIYLPL IPEAVIAMLA CARLGVMHSV VFAGFTAKAL QARIADAAAK 190 200 210 220 230 240 LLITSDGQFR RGKPAPLKDA ADEAVADPDS PVEHVVVVRR TGIDVSWTGG RDLWWHDVVD 250 260 270 280 290 300 AAAPEHTPEP FPAEQPLFLL YTSGTTGKPK GIVHTSGSYL TQAAYTHYYV FDIKADTDVF 310 320 330 340 350 360 WCTADIGWVT GHTYGVYGPL ANGVTEVLYE GTPDTPTQHR HFEIIEKYGV TIYYTAPTLI 370 380 390 400 410 420 RTFMKWGREI PDAHDLSSLR LLGSVGEPIN PEAWRWYRSV IGADRLPIVD TWWQTETGAT 430 440 450 460 470 480 MISPLPGVAA AKPGSAMRPL PGISARIVDD HGDQLVPGIH HGEHVTGYLV LDQPWPSMLR 490 500 510 520 530 540 GIWGDPDRYV ETYWSRFAEQ GWYFAGDSAY YDRDGAIWVV GRIDDVMNVS GHRLSTAEVE 550 560 570 580 590 600 SALVGHHGVA EAAVVGATDA TTGQAICAFV VLCADYQVHD GIVDELRAEV AREISPIAKP 610 620 630 640 650 REVHVVPELP KTRSGKIMRR LLRDIAENRE LGDTSTLLDP GVFDAIRAAK

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS02724.1.
RefSeq	NP_959341.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q744D4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000038638; EBMYCP00000037027; EBMYCG00000038633.
GeneID	2721073.
GenomeReviews	Gene locus MAP_0407c in contig AE016958_GR.
KEGG	mpa:MAP0407c.
NMPDR	fig|262316.1.peg.407.
PATRIC	17993184. VBIMycAvi108102_0433.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015141.
HOGENOM	HBG547964.
OMA	VISVSGH.
ProtClustDB	PRK00174.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q744D4_MYCPA

Accession

Primary (citable) accession number: Q744D4

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)