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Protein

Gag polyprotein

Gene

gag

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Virus exit from host cell

Keywords - Ligandi

Metal-binding, RNA-bindingSAAS annotation, Viral nucleoproteinUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinSAAS annotation
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cytoplasm SAAS annotation
  • Host nucleus SAAS annotation
  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ74452.
SMRiQ74452. Positions 2-427, 445-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 40116CCHC-typeInterPro annotationAdd
BLAST
Domaini408 – 42316CCHC-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the primate lentivirus group gag polyprotein family.SAAS annotation
Contains CCHC-type zinc fingers.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q74452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASVLSG GKLDAWEKIR LRPGGKKKYR LKHLVWASRE LERFALNPGL
60 70 80 90 100
LETAEGCQQL MEQLQSALRT GSEELKSLFN TIATLWCVHQ RIDIKDTKEA
110 120 130 140 150
LDKMEEIQNK SKQKVQQTAA ATGSSSQNYP IVQNAKGQMT HQSMSPRTLN
160 170 180 190 200
AWVKVIEEKG FSPEVIPMFS ALSEGATPQD LNMMLNIVGG HQAAMQMLKD
210 220 230 240 250
TINEEAAEWD RVHPVHAGPI PPGQMREPRG SDIAGTTSTL QEQIGWMTSN
260 270 280 290 300
PPIPVGEIYK RWIVLGLNKI VRMYSPVSIL DIRQGPKEPF RDYVDRFFKT
310 320 330 340 350
LRAEQATQEV KNWMTETLLV QNANPDCKSI LRALGTGATL EEMMTACQGV
360 370 380 390 400
GGPGHKARVL AEAMSQVQQA NVMMQRGNFR GQRTIKCFNC GKEGHLARNC
410 420 430 440 450
KAPRKRGCWK CGKEGHQMKD CTERQANFLG KIWPSSKGRP GNFPQSRPEP
460 470 480 490
TAPPAESFGM GEEIPPSPQQ EPRDKGLYPP LTSLKSLFGN DP
Length:492
Mass (Da):54,755
Last modified:November 1, 1996 - v1
Checksum:i0AF8135B49F46AFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39106 Genomic RNA. Translation: AAB51136.1.
PIRiS49086.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39106 Genomic RNA. Translation: AAB51136.1.
PIRiS49086.

3D structure databases

ProteinModelPortaliQ74452.
SMRiQ74452. Positions 2-427, 445-492.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR014817. Gag_p6.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF08705. Gag_p6. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the glycoprotein 120 coding region of a new HIV type 1 subtype A strain (HIV-1IbNg) from Nigeria."
    Howard T.M., Olaylele D.O., Rasheed S.
    AIDS Res. Hum. Retroviruses 10:1755-1757(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IbNgImported.
  2. "Molecular characterization of the gp120 encoding region of a new subtype A strain of HIV-1 (HIV-1IbNg) from Nigeria."
    Howard T.M., Olaleye D.O., Rasheed S.
    Biokemistri 5:61-74(1995)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IbNgImported.
  3. "Genomic structure and nucleotide sequence analysis of a new HIV type 1 subtype A strain from Nigeria."
    Howard T.M., Rasheed S.
    AIDS Res. Hum. Retroviruses 12:1413-1425(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IbNgImported.
  4. "Biological characterization of a new subtype-A variant of human immunodeficiency virus type 1 from Nigeria."
    Olaleye D.O., Sheng Z., Howard T.M., Rasheed S.
    Biokemistri 5:51-59(1996)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IbNgImported.
  5. "Isolation and characterization of a new subtype A variant of human immunodeficiency virus type I from Nigeria."
    Olaleye D.O., Sheng Z., Howard T.M., Rasheed S.
    Trop. Med. Int. Health 1:97-106(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IbNgImported.

Entry informationi

Entry nameiQ74452_9HIV1
AccessioniPrimary (citable) accession number: Q74452
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.