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Q743E7 (Q743E7_MYCPA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Name:purF EMBL AAS02955.1
Ordered Locus Names:MAP_0638
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site601For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding3011Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4471Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding5031Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding5061Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
Q743E7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2479F311272AE3E3

FASTA55159,284
        10         20         30         40         50         60 
MKCRFTPAGR DFAGQHARRI RRRGRAARRL RYVTNRSPGS RPIVTVAEPE QDFNAPREEC 

        70         80         90        100        110        120 
GVFGVWAPGE EVAKLTYYGL YALQHRGQEA AGIAVADGSQ VLVFKDLGLV SQVFDEQTLA 

       130        140        150        160        170        180 
AMQGHVAIGH CRYSTTGDTT WENAQPVFRN TAAGTGVALG HNGNLVNTAE LAARARDAGL 

       190        200        210        220        230        240 
IAKRAPAPAT TDSDILGALL AHGAADSTLE QAALDLLPTV RGAFCLTFMD ENTLYACRDP 

       250        260        270        280        290        300 
HGVRPLSLGR LDRGWVVASE TAALDIVGAS FVRDIEPGEL LAIDADGVRS TRFANPTPKG 

       310        320        330        340        350        360 
CVFEYVYLAR PDSTIAGRSV HATRVEIGRR LARERPVEAD LVIGVPESGT PAAVGYAQES 

       370        380        390        400        410        420 
GIPYGQGLMK NAYVGRTFIQ PSQTIRQLGI RLKLNPLREV IRGKRLIVVD DSIVRGNTQR 

       430        440        450        460        470        480 
ALLRMLREAG AVEVHVRIAS PPVKWPCFYG IDFPSPAELI ANAVEDKHEM LEAVRHAIGA 

       490        500        510        520        530        540 
DSLGYISLRG LIAASEQPAS RLCTACFDGQ YPIELPGETA LGKNVIEHML ANAARGAGLD 

       550 
DLAADEVPVV H

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References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS02955.1.
RefSeqNP_959572.1. NC_002944.2.

3D structure databases

HSSPHSSP built from PDB template 1AO0 based on UniProtKB P00497.
ProteinModelPortalQ743E7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000036958; EBMYCP00000035347; EBMYCG00000036953.
GeneID2721802.
GenomeReviewsGene locus MAP_0638 in contig AE016958_GR.
KEGGmpa:MAP0638.
NMPDRfig|262316.1.peg.638.
PATRIC17993667. VBIMycAvi108102_0672.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016850.
HOGENOMHBG392416.
OMAVWAPGEE.
ProtClustDBPRK07847.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ743E7_MYCPA
AccessionPrimary (citable) accession number: Q743E7
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info