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Reviewed, UniProtKB/Swiss-Prot Q742Z0 (MHPB_MYCPA)

Last modified September 22, 2009. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
    EC=1.13.11.16
Gene names
Name: mhpB
Ordered Locus Names: MAP_0695
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively By similarity.

Catalytic activity

3-(2,3-dihydroxyphenyl)propanoate + O2 = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. HAMAP MF_01653

2,3-dihydroxicinnamic acid + O2 = 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate. HAMAP MF_01653

Cofactor

Fe2+ ion By similarity.

Pathway

Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01653

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the ligB/mhpB extradiol dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3123122,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase HAMAP MF_01653
PRO_0000337654

Sites

Active site1151Proton donor By similarity
Active site1791Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q742Z0-1 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 49A3010C87232A85

FASTA31233,150
        10         20         30         40         50         60 
MALALCCMSH SPLLNLPGPS RDLLDDIDAA IARARGFVED YDPQLVVIFS PDHYNGFFYK 

        70         80         90        100        110        120 
VMPPFCIGSS ASGVGDYGTH AGPLDVPEKL AVDCAQAVLD AGVDIAVSAS MDVDHGTVQP 

       130        140        150        160        170        180 
LEKLFGTAIS RPVIPVFVNA IGVPLGPMHR CRALGAAVGT YLATLDKRVL VMGSGGLSHS 

       190        200        210        220        230        240 
PPVPTLATAP EPVLQRIVHG APMTAEQRQA RQAAVIDAAR SFAAGDSALQ PLNPTWDHRF 

       250        260        270        280        290        300 
LEIIDRGSLS ELDRWSNSFV THEGGGSAHE IRTWVAAFAA LQAAGPYETT MRYYTPAPEL 

       310 
IAGFAIRTAR PK 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

AE016958 Genomic DNA. Translation: AAS03012.1. Different initiation.
RefSeqNP_959629.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2720204.
GenomeReviewsGene locus MAP_0695 in contig AE016958_GR.
KEGGmpa:MAP0695.
NMPDRfig|262316.1.peg.695.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ742Z0.

Family and domain databases

HAMAPMF_01653.
[Tree]
InterProIPR004183. Xdiol_dOase_3B.
[Graphical view]
PfamPF02900. LigB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMHPB_MYCPA
AccessionPrimary (citable) accession number: Q742Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 22, 2009
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents