Q740S4 (Q740S4_MYCPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malto-oligosyltrehalose trehalohydrolase PIRNR PIRNR006337
Short name=MTHase PIRNR PIRNR006337
EC=3.2.1.141 PIRNR PIRNR006337

Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase PIRNR PIRNR006337
Maltooligosyl trehalose trehalohydrolase PIRNR PIRNR006337

Gene names

Name:	glgZ EMBL AAS03585.1
Ordered Locus Names:	MAP_1268c

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	590 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan. PIRNR PIRNR006337
Pathway	Glycan biosynthesis; trehalose biosynthesis. PIRNR PIRNR006337
Subcellular location	Cytoplasm By similarity PIRSR PIRSR006337-1.
Sequence similarities	Belongs to the glycosyl hydrolase 13 family. PIRNR PIRNR006337

Ontologies

Keywords
Molecular function	Glycosidase PIRNR PIRNR006337 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	248	1	Nucleophile By similarity PIRSR PIRSR006337-1
	Active site	285	1	Proton donor By similarity PIRSR PIRSR006337-1
	Site	384	1	Transition state stabilizer By similarity PIRSR PIRSR006337-3

Sequences

	Sequence		Length	Mass (Da)
	Q740S4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C61F7A51A3C88682	FASTA	590	65,287
	10 20 30 40 50 60 MTEQKTEFRV WAPKPARVRL DVEGRPHAMT RTDDGWWHAA VACAPDARYG FLLDDDPTVL 70 80 90 100 110 120 PDPRSPRQPD GVHTRSQLWD PAAATWTDSA WPGRSTHGAV IYELHLGTFT AAGTFDSAIE 130 140 150 160 170 180 KLDYLVDLGV DFVELMPVNS FAGTHGWGYD GVLWYSVHEP YGGPDGLVRF VDACHARGLG 190 200 210 220 230 240 VLIDAVFNHL GPSGNYLPRF GPYLSSASNP WGEGINIADA DSDEVRRYII GCALRWMRDF 250 260 270 280 290 300 HADGLRLDAV HALVDTTAIH ILEELSTETD WLATQLGRPL SLIAESDLND PRLITARERG 310 320 330 340 350 360 GYGLTAQWAD DIHHAIHTAV SGERQGYYAD FGSIATLAHT LRHGYFHAAT YSSFRRRRHG 370 380 390 400 410 420 RPLDTSAQTG IPATRLLAYT CTHDQVGNRA LGDRPSQNLT AGQLAVKAVL ALLSPYTAML 430 440 450 460 470 480 FMGEEYGAST PFQFFSSHPE PELARATAEG RKTEFAEHGW DASKKGEIPD PQDPQTFARS 490 500 510 520 530 540 KLNWDEVGTG EHARLHRLYR DLIALRHNDP DLADPWLEHL TVDYDEDQRW IVLARGRLRI 550 560 570 580 590 VCNLGAEPVT VPVGGELMLA WDEPTVDADT TVLQGHSFAI LSTPGQPVDN

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS03585.1.
RefSeq	NP_960202.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q740S4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000039371; EBMYCP00000037760; EBMYCG00000039366.
GeneID	2720866.
GenomeReviews	Gene locus MAP_1268c in contig AE016958_GR.
KEGG	mpa:MAP1268c.
NMPDR	fig|262316.1.peg.1268.
PATRIC	17995007. VBIMycAvi108102_1334.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016657.
HOGENOM	HBG367595.
OMA	EGFVYQG.
ProtClustDB	CLSK799816.
Family and domain databases
InterPro	IPR015902. Alpha_amylase. IPR006047. Glyco_hydro_13_cat_dom. IPR004193. Glyco_hydro_13_N. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR022567. Maltooligo_trehalose_bac_C. IPR012768. Trehalose_TreZ. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 2 hits. G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K01236.
PANTHER	PTHR10357. Alpha_amylase. 1 hit. PTHR10357:SF21. PTHR10357:SF21. 1 hit.
Pfam	PF00128. Alpha-amylase. 1 hit. PF02922. CBM_48. 1 hit. PF11941. DUF3459. 1 hit. [Graphical view]
PIRSF	PIRSF006337. Trehalose_TreZ. 1 hit.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit. SSF81296. Ig_E-set. 1 hit.
TIGRFAMs	TIGR02402. Trehalose_TreZ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q740S4_MYCPA

Accession

Primary (citable) accession number: Q740S4

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)