Q740P4 (TRPC_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	MAP_1305

Organism

Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]

Taxonomic identifier

262316 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) › Mycobacterium avium › Mycobacterium paratuberculosis

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP-Rule MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP-Rule MF_00134
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Indole-3-glycerol phosphate synthase HAMAP-Rule MF_00134		PRO_1000018500

Sequences

	Sequence		Length	Mass (Da)
	Q740P4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B3EFE54C570ADD32	FASTA	272	28,125
	10 20 30 40 50 60 MSPATVLDSI LEGVRADVAA REALISLSEI KAAAAAAPPP LDVMAALREP GIGVIAEVKR 70 80 90 100 110 120 ASPSAGSLAT IADPAKLARA YEDGGARIIS VLTEERRFHG SLDDLDAVRA AVSIPVLRKD 130 140 150 160 170 180 FVVQPYQIHE ARAHGADMLL LIVAALEQSA LVSMLDRTES LGMTALVEVH TEEEADRALR 190 200 210 220 230 240 AGAKVIGVNA RDLATLEVDR DCFARIAPGL PSNVIRIAES GVRGTGDLLA YAGAGADAVL 250 260 270 VGEGLVKSGD PRAAVADLVT AGTHPSCPKP AR

References

[1]

"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016958 Genomic DNA. Translation: AAS03622.1.
RefSeq	NP_960239.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q740P4.
ModBase	Search...
Protein-protein interaction databases
STRING	262316.MAP1305.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAS03622; AAS03622; MAP_1305.
GeneID	2718762.
KEGG	mpa:MAP1305.
PATRIC	17995087. VBIMycAvi108102_1374.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
KO	K01609.
OMA	YQAGGAR.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	MAVI262316:GCQR-1325-MONOMER.
UniPathway	UPA00035; UER00043.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00134_B. IGPS_B.
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_MYCPA

Accession

Primary (citable) accession number: Q740P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program