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Q740I5

- OTC_MYCPA

UniProt

Q740I5 - OTC_MYCPA

Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

    Catalytic activityi

    Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 71Carbamoyl phosphateUniRule annotation
    Sitei28 – 281Important for structural integrityUniRule annotation
    Binding sitei78 – 781Carbamoyl phosphateUniRule annotation
    Binding sitei102 – 1021Carbamoyl phosphateUniRule annotation
    Sitei142 – 1421Important for structural integrityUniRule annotation
    Binding sitei161 – 1611OrnithineBy similarity
    Binding sitei225 – 2251OrnithineBy similarity
    Binding sitei275 – 2751Carbamoyl phosphateUniRule annotation
    Binding sitei293 – 2931Carbamoyl phosphateUniRule annotation

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Enzyme and pathway databases

    BioCyciMAVI262316:GCQR-1386-MONOMER.
    UniPathwayiUPA00068; UER00112.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
    Short name:
    OTCaseUniRule annotation
    Gene namesi
    Name:argFUniRule annotation
    Ordered Locus Names:MAP_1365
    OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
    Taxonomic identifieri262316 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000000580: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Ornithine carbamoyltransferasePRO_0000112952Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262316.MAP1365.

    Structurei

    3D structure databases

    ProteinModelPortaliQ740I5.
    SMRiQ740I5. Positions 4-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 555Carbamoyl phosphate bindingUniRule annotation
    Regioni129 – 1324Carbamoyl phosphate bindingUniRule annotation
    Regioni229 – 2302Ornithine bindingUniRule annotation
    Regioni264 – 2674Carbamoyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0078.
    KOiK00611.
    OMAiTPFWPYQ.
    OrthoDBiEOG690MGV.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_01109. OTCase.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
    PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q740I5-1 [UniParc]FASTAAdd to Basket

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    MTPRHFLRDD DLSPAEQAEV LALAAELKKD PFSARPLEGP RGVAVLFDKN    50
    STRTRFSFEV GIAQLGGHAV VVDARSTQLG RDETLEDTAR VLSRYVEAIV 100
    WRTFEQQRLE AMAGAATVPV INALSDEFHP CQMLADLQAI AEHKGSLSGL 150
    RMCYLGDGAN NMAHSLMLGG VTAGIHVTIA APDGFTPAPE FVAAARRRAE 200
    STGATVTLTT DARAAARGVD VLVTDTWTSM GQEDDGLDRR TPFWPYQLNA 250
    DLVSLADPEA IVLHCLPAHR GEEITDEVMD GPSSVVWDEA ENRLHAQKAL 300
    LTWLLERQS 309
    Length:309
    Mass (Da):33,595
    Last modified:July 5, 2004 - v1
    Checksum:i7500E6BE03398101
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS03682.1.
    RefSeqiNP_960299.1. NC_002944.2.

    Genome annotation databases

    EnsemblBacteriaiAAS03682; AAS03682; MAP_1365.
    GeneIDi2720213.
    KEGGimpa:MAP1365.
    PATRICi17995219. VBIMycAvi108102_1439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016958 Genomic DNA. Translation: AAS03682.1 .
    RefSeqi NP_960299.1. NC_002944.2.

    3D structure databases

    ProteinModelPortali Q740I5.
    SMRi Q740I5. Positions 4-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262316.MAP1365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS03682 ; AAS03682 ; MAP_1365 .
    GeneIDi 2720213.
    KEGGi mpa:MAP1365.
    PATRICi 17995219. VBIMycAvi108102_1439.

    Phylogenomic databases

    eggNOGi COG0078.
    KOi K00611.
    OMAi TPFWPYQ.
    OrthoDBi EOG690MGV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00112 .
    BioCyci MAVI262316:GCQR-1386-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_01109. OTCase.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
    PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
      Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
      Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-968 / K-10.

    Entry informationi

    Entry nameiOTC_MYCPA
    AccessioniPrimary (citable) accession number: Q740I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3