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Q740I5

- OTC_MYCPA

UniProt

Q740I5 - OTC_MYCPA

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Protein

Ornithine carbamoyltransferase

Gene
argF, MAP_1365
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline By similarity.UniRule annotation

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71Carbamoyl phosphate By similarity
Sitei28 – 281Important for structural integrity By similarity
Binding sitei78 – 781Carbamoyl phosphate By similarity
Binding sitei102 – 1021Carbamoyl phosphate By similarity
Sitei142 – 1421Important for structural integrity By similarity
Binding sitei161 – 1611Ornithine By similarity
Binding sitei225 – 2251Ornithine By similarity
Binding sitei275 – 2751Carbamoyl phosphate By similarity
Binding sitei293 – 2931Carbamoyl phosphate By similarity

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-1386-MONOMER.
UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:MAP_1365
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000000580: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Ornithine carbamoyltransferaseUniRule annotationPRO_0000112952Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP1365.

Structurei

3D structure databases

ProteinModelPortaliQ740I5.
SMRiQ740I5. Positions 4-307.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 555Carbamoyl phosphate binding By similarity
Regioni129 – 1324Carbamoyl phosphate binding By similarity
Regioni229 – 2302Ornithine binding By similarity
Regioni264 – 2674Carbamoyl phosphate binding By similarity

Sequence similaritiesi

Belongs to the ATCase/OTCase family.

Phylogenomic databases

eggNOGiCOG0078.
KOiK00611.
OMAiTPFWPYQ.
OrthoDBiEOG690MGV.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q740I5-1 [UniParc]FASTAAdd to Basket

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MTPRHFLRDD DLSPAEQAEV LALAAELKKD PFSARPLEGP RGVAVLFDKN    50
STRTRFSFEV GIAQLGGHAV VVDARSTQLG RDETLEDTAR VLSRYVEAIV 100
WRTFEQQRLE AMAGAATVPV INALSDEFHP CQMLADLQAI AEHKGSLSGL 150
RMCYLGDGAN NMAHSLMLGG VTAGIHVTIA APDGFTPAPE FVAAARRRAE 200
STGATVTLTT DARAAARGVD VLVTDTWTSM GQEDDGLDRR TPFWPYQLNA 250
DLVSLADPEA IVLHCLPAHR GEEITDEVMD GPSSVVWDEA ENRLHAQKAL 300
LTWLLERQS 309
Length:309
Mass (Da):33,595
Last modified:July 5, 2004 - v1
Checksum:i7500E6BE03398101
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS03682.1.
RefSeqiNP_960299.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS03682; AAS03682; MAP_1365.
GeneIDi2720213.
KEGGimpa:MAP1365.
PATRICi17995219. VBIMycAvi108102_1439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016958 Genomic DNA. Translation: AAS03682.1 .
RefSeqi NP_960299.1. NC_002944.2.

3D structure databases

ProteinModelPortali Q740I5.
SMRi Q740I5. Positions 4-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262316.MAP1365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS03682 ; AAS03682 ; MAP_1365 .
GeneIDi 2720213.
KEGGi mpa:MAP1365.
PATRICi 17995219. VBIMycAvi108102_1439.

Phylogenomic databases

eggNOGi COG0078.
KOi K00611.
OMAi TPFWPYQ.
OrthoDBi EOG690MGV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00112 .
BioCyci MAVI262316:GCQR-1386-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1370. 2 hits.
HAMAPi MF_01109. OTCase.
InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view ]
Pfami PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view ]
PRINTSi PR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMi SSF53671. SSF53671. 1 hit.
TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-968 / K-10.

Entry informationi

Entry nameiOTC_MYCPA
AccessioniPrimary (citable) accession number: Q740I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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