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Q740D6 (DER_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene names
Name:der
Synonyms:engA
Ordered Locus Names:MAP_1415
OrganismMycobacterium paratuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1770 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195

Subunit structure

Associates with the 50S ribosomal subunit By similarity.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Der subfamily.

Contains 2 G (guanine nucleotide-binding) domains.

Contains 1 KH-like domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466GTPase Der HAMAP MF_00195
PRO_1000011671

Regions

Domain41 – 146106G 1
Domain214 – 322109G 2
Domain376 – 45984KH-like
Nucleotide binding36 – 438GTP 1 Potential
Nucleotide binding83 – 875GTP 1 Potential
Nucleotide binding145 – 1484GTP 1 Potential
Nucleotide binding209 – 2168GTP 2 Potential
Nucleotide binding256 – 2605GTP 2 Potential
Nucleotide binding321 – 3244GTP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
Q740D6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 98FB27D3E2C0BCB3

FASTA46650,703
        10         20         30         40         50         60 
MTHDGTWSDE SDWEAVEFEL DEAAHAPPAP VVAVVGRPNV GKSTLVNRIL GRREAVVQDV 

        70         80         90        100        110        120 
PGVTRDRVSY DALWTGRRFV VQDTGGWEPD AKGLQQLVAE QASVAMRTAD AVILVVDALV 

       130        140        150        160        170        180 
GATTADEAAA RILLRSGKPV FLAANKVDSD KAEADAAMLW SLGLGEPHPI SAMHGRGVAD 

       190        200        210        220        230        240 
LLDEVLAALP EVSEVAPRPG GPRRVALVGK PNVGKSSLLN KLAGDQRSVV HDVAGTTVDP 

       250        260        270        280        290        300 
VDSLIELGDR VWRFVDTAGL RRKVGQASGH EFYASVRTHS AIDAAEVVIV LIDASAPLTE 

       310        320        330        340        350        360 
QDQRVLSMVI EAGRALVLAF NKWDLVDEDR RELLEREIDR ELVQLRWAQR VNISAKTGRA 

       370        380        390        400        410        420 
VAKLVPAMET ALASWDTRIA TGPLNSWLKE VVAATPPPVR GGKQPRILFA TQAAARPPTF 

       430        440        450        460 
VLFTTGFLEA GYRRFLERRL REAFGFEGTP IRINVRVREK RGARRR

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE016958 Genomic DNA. Translation: AAS03732.1.
RefSeqNP_960349.1. NC_002944.2.

3D structure databases

HSSPHSSP built from PDB template 1MKY based on UniProtKB Q9X1F8.
ProteinModelPortalQ740D6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000037246; EBMYCP00000035635; EBMYCG00000037241.
GeneID2719443.
GenomeReviewsGene locus MAP_1415 in contig AE016958_GR.
KEGGmpa:MAP1415.
NMPDRfig|262316.1.peg.1415.
PATRIC17995319. VBIMycAvi108102_1489.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016947.
HOGENOMHBG592135.
OMALAVNKCE.
ProtClustDBPRK03003.

Family and domain databases

HAMAPMF_00195. GTPase_Der.
[Tree]
InterProIPR003593. ATPase_AAA+_core.
IPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
Gene3DG3DSA:3.30.300.20. KH_prok. 1 hit.
KOK03977.
PANTHERPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. Small_GTP. 2 hits.
ProtoNetSearch...

Entry information

Entry nameDER_MYCPA
AccessionPrimary (citable) accession number: Q740D6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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